Analysis Tools
cellular
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• at 9 months of age, the number of mature spermatozoa in mutant seminiferous tubles is reduced by 25% relative to wild-type mice
• mutant testis sections contain only 20.4 3.3 spermatozoon-containing tubuli per 100 tubuli vs 36.3 5.4 in wild-type testis sections
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• at 6 months of age, the epididymal sperm count of mutant males is reduced by 60% relative to wild-type males
• however, male homozygotes are fully capable of siring litters, with no apparent reduction in litter size
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reproductive system
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• at 9 months of age, the number of mature spermatozoa in mutant seminiferous tubles is reduced by 25% relative to wild-type mice
• mutant testis sections contain only 20.4 3.3 spermatozoon-containing tubuli per 100 tubuli vs 36.3 5.4 in wild-type testis sections
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• male homozygotes display a 27% reduction in testicular weight relative to wild-type males
• however, no significant differences in body weight or body length are observed
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• homozygotes show a modest delay in male germ cell development, possibly at the stage of meiosis
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• at 6 months of age, the epididymal sperm count of mutant males is reduced by 60% relative to wild-type males
• however, male homozygotes are fully capable of siring litters, with no apparent reduction in litter size
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endocrine/exocrine glands
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• male homozygotes display a 27% reduction in testicular weight relative to wild-type males
• however, no significant differences in body weight or body length are observed
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adipose tissue
| N |
• surprisingly, at 18 months of age, mutant epididymal fat pad weights are not significantly different from those of wild-type mice
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homeostasis/metabolism
| N |
• at 6-12 months of age, homozygotes show no detectable differences in blood glucose levels, serum cholesterol, serum triglycerides, or blood cell counts relative to wild-type mice
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