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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bmp4tm3.1Blh
targeted mutation 3.1, Brigid L Hogan
MGI:2181190
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bmp4tm3.1Blh/Bmp4tm3.1Blh involves: 129S6/SvEvTac * Black Swiss MGI:2183179
ht2
Bmp4tm1Blh/Bmp4tm3.1Blh involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss MGI:2183180
ht3
Bmp4tm1Blh/Bmp4tm3.1Blh involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR MGI:3811284
cn4
Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR MGI:2679084
cn5
Bmp4tm3.1Blh/Bmp4+
Tg(Sftpc-cre)1Blh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3811315
cn6
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR MGI:2679083


Genotype
MGI:2183179
hm1
Allelic
Composition
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• abnormal eyes: sometimes appear slightly smaller than normal




Genotype
MGI:2183180
ht2
Allelic
Composition
Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (10 available)
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals at E17.5 have no apparent defects other than eye dysmorphology, but no live births are noted

vision/eye




Genotype
MGI:3811284
ht3
Allelic
Composition
Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (10 available)
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between P1 and P7

cardiovascular system
N
• no outflow tract abnormalities are seen
• severe atrial septum primum abnormality resulting in an ostium primum atrial septation defect or partial atrial ventricular canal defect
• however, the atrioventicular and ventricular septa are similar to controls

vision/eye
• lack normal eyes




Genotype
MGI:2679084
cn4
Allelic
Composition
Bmp4tm1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation (2 available); any Bmp4 mutation (10 available)
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (10 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no neonates are found

cardiovascular system
• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart
• present in 80% of embryos at E15.5 - E16.5
• single atrioventricular junction with a common valve

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrioventricular Septal Defect; AVSD 606215 J:86001




Genotype
MGI:3811315
cn5
Allelic
Composition
Bmp4tm3.1Blh/Bmp4+
Tg(Sftpc-cre)1Blh/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (10 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• at E16.5 and E18.5, 50% of mice exhibit abnormal lungs with large sacs
• at E16.5, cell proliferation lung epithelium and mesenchyme is decreased 50% compared to in wild-type mice while apoptosis is increased compared to in wild-type mice




Genotype
MGI:2679083
cn6
Allelic
Composition
Bmp4tm3.1Blh/Bmp4tm3.1Blh
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation (0 available); any Bmp4 mutation (10 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
N
• no outflow tract abnormalities are seen
• atrial septal defect similar to that in mice heterozygous for Bmp4tm1Blh and Bmp4tm3.1Blh

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrioventricular Septal Defect; AVSD 606215 J:86001





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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory