• abnormal eyes: sometimes appear slightly smaller than normal

• animals at E17.5 have no apparent defects other than eye dysmorphology, but no live births are noted

• die between P1 and P7

• no outflow tract abnormalities are seen (J:86001)

• severe atrial septum primum abnormality resulting in an ostium primum atrial septation defect or partial atrial ventricular canal defect

• however, the atrioventicular and ventricular septa are similar to controls

• lack normal eyes

• no neonates are found

• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart

• present in 80% of embryos at E15.5 - E16.5

• single atrioventricular junction with a common valve

• at E16.5 and E18.5, 50% of mice exhibit abnormal lungs with large sacs

• at E16.5, cell proliferation lung epithelium and mesenchyme is decreased 50% compared to in wild-type mice while apoptosis is increased compared to in wild-type mice

• no outflow tract abnormalities are seen (J:86001)

• atrial septal defect similar to that in mice heterozygous for Bmp4^tm1Blh and Bmp4^tm3.1Blh