Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation
(0 available);
any
Bmp4 mutation
(21 available)
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vision/eye
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• abnormal eyes: sometimes appear slightly smaller than normal
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Allelic Composition |
Bmp4tm1Blh/Bmp4tm3.1Blh
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Genetic Background |
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation
(2 available);
any
Bmp4 mutation
(21 available)
Bmp4tm3.1Blh mutation
(0 available);
any
Bmp4 mutation
(21 available)
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mortality/aging
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• animals at E17.5 have no apparent defects other than eye dysmorphology, but no live births are noted
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vision/eye
Allelic Composition |
Bmp4tm1Blh/Bmp4tm3.1Blh
|
|
Genetic Background |
involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation
(2 available);
any
Bmp4 mutation
(21 available)
Bmp4tm3.1Blh mutation
(0 available);
any
Bmp4 mutation
(21 available)
|
|
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mortality/aging
cardiovascular system
N |
• no outflow tract abnormalities are seen
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• severe atrial septum primum abnormality resulting in an ostium primum atrial septation defect or partial atrial ventricular canal defect
• however, the atrioventicular and ventricular septa are similar to controls
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vision/eye
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation
(0 available);
any
Bmp4 mutation
(21 available)
Tg(Sftpc-cre)1Blh mutation
(0 available)
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respiratory system
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• at E16.5 and E18.5, 50% of mice exhibit abnormal lungs with large sacs
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• at E16.5, cell proliferation lung epithelium and mesenchyme is decreased 50% compared to in wild-type mice while apoptosis is increased compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm3.1Blh mutation
(0 available);
any
Bmp4 mutation
(21 available)
Tg(Tnnt2-cre)5Blh mutation
(1 available)
|
|
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mortality/aging
cardiovascular system
N |
• no outflow tract abnormalities are seen
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp4tm1Blh mutation
(2 available);
any
Bmp4 mutation
(21 available)
Bmp4tm3.1Blh mutation
(0 available);
any
Bmp4 mutation
(21 available)
Tg(Tnnt2-cre)5Blh mutation
(1 available)
|
|
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mortality/aging
cardiovascular system
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• at E12.5 about a 20% decrease in proliferation is detected in the atrioventricular cushions but not in other areas of the heart
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• present in 80% of embryos at E15.5 - E16.5
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• single atrioventricular junction with a common valve
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