Phenotypes associated with this allele

• Allele Symbol: Dclre1a^tm1Roka
• Allele Name: targeted mutation 1, Roland Kanaar
• Allele ID: MGI:2180947
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dclre1a^tm1Roka/Dclre1a^tm1Roka	Not Specified	MGI:3055834

Genotype
MGI:3055834

hm1

• Allelic Composition: Dclre1a^tm1Roka/Dclre1a^tm1Roka
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:62832 )

• homozygotes are viable, fertile and macroscopically normal up to at least 12 months of age, but show increased sensitivity to mitomycin C (MMC)-induced lethality

• in females, MMC injections of 10 and 15 mg/kg of body weight result in enhanced sensitivity; a shorter latency is observed with 15 mg/kg

• in males, 7.5 mg/kg is lethal for 30% of homozygotes, while all heterozygotes survive; at 10 mg/kg, only 10% of homozygotes survive treatment, versus 70% of heterozygotes

cellular

abnormal cell physiology ( J:62832 )

• homozygous null ES cells are viable but are ~2-fold more sensitive to mitomycin C than wild-type

• notably, mutant ES cells are not significantly sensitive to other DNA interstrand cross-linking agents, UV (254 nm), methyl methanesulfonate, or gamma rays

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:62832 )

• homozygotes are viable, fertile and macroscopically normal up to at least 12 months of age, but show increased sensitivity to mitomycin C (MMC)-induced lethality

• in females, MMC injections of 10 and 15 mg/kg of body weight result in enhanced sensitivity; a shorter latency is observed with 15 mg/kg

• in males, 7.5 mg/kg is lethal for 30% of homozygotes, while all heterozygotes survive; at 10 mg/kg, only 10% of homozygotes survive treatment, versus 70% of heterozygotes