Phenotypes associated with this allele

• Allele Symbol: Comp^tm1Aol
• Allele Name: targeted mutation 1, Ake Oldberg
• Allele ID: MGI:2180787
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Comp^tm1Aol/Comp^tm1Aol	involves: 129S1/Sv * 129X1/SvJ	MGI:5763182
hm2	Comp^tm1Aol/Comp^tm1Aol	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3037836

Genotype
MGI:5763182

hm1

• Allelic Composition: Comp^tm1Aol/Comp^tm1Aol
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular wound healing ( J:230573 )

• following carotid artery wire-injury, neointima area is greatly increased compared with wild-type mice

• however, mice exhibit normal re-endothelialization following vascular wounding by wire injury

homeostasis/metabolism

abnormal vascular wound healing ( J:230573 )

• following carotid artery wire-injury, neointima area is greatly increased compared with wild-type mice

• however, mice exhibit normal re-endothelialization following vascular wounding by wire injury

Genotype
MGI:3037836

hm2

• Allelic Composition: Comp^tm1Aol/Comp^tm1Aol
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:76781 )

• viable and fertile; no gross morphological or histological abnormalities, skeletal development and mature skeletal ultrastructure are indistinguishable from controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	multiple epiphyseal dysplasia	DOID:12721		J:76781
NOT	pseudoachondroplasia	DOID:0080047	OMIM:177170	J:76781