All Phenotypes Apoa1<tm1Bres> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoa1^tm1Bres/Apoa1^tm1Bres	involves: 129S4/SvJae * C57BL/6	MGI:3783888
ht2	Apoa1^tm1Bres/Apoa1⁺	involves: 129S4/SvJae * C57BL/6	MGI:3783889
cx3	Apoa1^tm1Bres/Apoa1^tm1Bres Apoa2^tm1Bres/Apoa2^tm1Bres	involves: 129S4/SvJae * C57BL/6	MGI:3783891
cx4	Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0	involves: 129S4/SvJae * C57BL/6 * CBA/J	MGI:4941578

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased 86% and 83%, respectively, when mice are fed a normal or Western-type diet compared to wild-type mice

decreased circulating cholesterol level ( J:40819 )

• mice exhibit a 72% reduced in plasma cholesterol level compared to in wild-type mice

• when fed a Western-type diet, mice exhibit a 73% reduced in plasma cholesterol level compared to in wild-type mice

• mice exhibit a 1.9-fold and 2.2-fold decrease in free cholesterol and cholesteryl ester content, respectively, compared to in wild-type mice

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a 74% decrease in HDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 83% decrease in HDL-C levels compared to wild-type mice

decreased circulating LDL cholesterol level ( J:40819 )

• mice exhibit a 62% decrease in VLDL-C and LDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 42% decrease in VLDL-C and LDL-C levels compared to wild-type mice

decreased circulating VLDL cholesterol level ( J:40819 )

• mice exhibit a 62% decrease in VLDL-C and LDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 42% decrease in VLDL-C and LDL-C levels compared to wild-type mice

increased circulating triglyceride level ( J:40819 )

• mice exhibit an 8-fold decrease in triglycerides compared to wild-type mice

cellular

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased 86% and 83%, respectively, when mice are fed a normal or Western-type diet compared to wild-type mice

Allelic Composition	Apoa1^tm1Bres/Apoa1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1^tm1Bres mutation (0 available); any Apoa1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased when mice are fed a normal or Western-type diet compared to wild-type mice

decreased circulating HDL cholesterol level ( J:40819 )

• HDL-C levels are 78% of wild-type

cellular

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased when mice are fed a normal or Western-type diet compared to wild-type mice

Allelic Composition	Apoa1^tm1Bres/Apoa1^tm1Bres Apoa2^tm1Bres/Apoa2^tm1Bres
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1^tm1Bres mutation (0 available); any Apoa1 mutation (16 available)
Apoa2^tm1Bres mutation (1 available); any Apoa2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 50% or more reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes

Allelic Composition	Apoa1^tm1Bres/Apoa1^tm1Bres Tg(Mt1-CETP)#Tall/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoa1^tm1Bres mutation (0 available); any Apoa1 mutation (16 available)
Tg(Mt1-CETP)#Tall mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a further 44% reduction in HDL-C levels compared to in Apoa1^tm1Bres homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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