muscle

increased variability of skeletal muscle fiber size ( J:67174 )

• at 6 weeks of age

centrally nucleated skeletal muscle fibers ( J:67174 )

• at 6 weeks of age

skeletal muscle fiber degeneration ( J:67174 )

skeletal muscle atrophy ( J:67174 )

• at 6 weeks of age

abnormal muscle physiology ( J:67174 )

• skeletal muscles exhibit increased neuronal nitric oxide synthase (nNOS) activity compared to in wild-type muscles

myopathy ( J:67174 )

• at 6 weeks of age, mice exhibit myopathic features, including variation in fiber size, atrophic fibers, internally placed nuclei, and increased endomysium compared with wild-type mice

growth/size

decreased body size ( J:67174 )

• at 6 weeks of age

postnatal growth retardation ( J:67174 )

skeleton

kyphosis ( J:67174 )

• at 6 weeks of age

behavior/neurological

hindlimb paralysis ( J:67174 )

• at 6 weeks of age

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:67174 )

• skeletal muscles exhibit increased neuronal nitric oxide synthase (nNOS) activity compared to in wild-type muscles

Mouse Models of Human Disease		OMIM ID	Ref(s)
Muscular Dystrophy, Limb-Girdle, Type 1C; LGMD1C		607801	J:67174