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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ckmm-Cav3)1Ysu
transgene insertion 1, Yoshihide Sunada
MGI:2180562
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Ckmm-Cav3)1Ysu/0 involves: C57BL/Slc * DBA/Slc MGI:5286560


Genotype
MGI:5286560
tg1
Allelic
Composition
Tg(Ckmm-Cav3)1Ysu/0
Genetic
Background
involves: C57BL/Slc * DBA/Slc
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• cardiac myofibers show marked size variability on both longitudinal and transverse sections when compared to controls
• hypertrophy of cardiac myofibers
• increased mean cardiac muscle fiber diameter
• transgenic mice at 6 weeks of age show thickening of the interventricular septum
• increased cardiac weight at 4, 12, 24 and 36 weeks of age when compared with controls
• statistically significant increases in the cardiac weight-to-body weight ratio at 4, 12, 24 and 36 weeks of age when compared with controls
• small left ventricular chamber due to thickening of interventricular septum and left ventricle posterior wall at 6 weeks of age
• thickening of the posterior wall of the left ventricle at 6 weeks of age
• hypercontractility (increased left ventricular fractional shortening)
• diastolic dysfunction (decreased left ventricular end diastolic diameter)

muscle
• cardiac myofibers show marked size variability on both longitudinal and transverse sections when compared to controls
• hypertrophy of cardiac myofibers
• increased mean cardiac muscle fiber diameter
• at 6 weeks of age
• skeletal muscles exhibit increased neuronal nitric oxide synthase (nNOS) activity compared to in wild-type muscles
• hypercontractility (increased left ventricular fractional shortening)
• at 6 weeks of age, mice exhibit myopathic features, including variation in fiber size, atrophic fibers, internally placed nuclei, and increased endomysium compared with wild-type mice

growth/size/body
• at 6 weeks of age (J:67174)
• significantly smaller than controls at 4, 12, 24 and 36 weeks of age (J:87692)
• poor postnatal growth (J:87692)

skeleton
• at 6 weeks of age (J:67174)
• kyphosis of the spine from 12 weeks of age (J:87692)

behavior/neurological
• at 6 weeks of age (J:67174)
• paralysis of the hindlimbs from 12 weeks of age (J:87692)

homeostasis/metabolism
• skeletal muscles exhibit increased neuronal nitric oxide synthase (nNOS) activity compared to in wild-type muscles





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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory