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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mtrtm1Lcb
targeted mutation 1, Lawrence C Brody
MGI:2180496
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mtrtm1Lcb/Mtrtm1Lcb 129S/SvEv-Mtrtm1Lcb MGI:3036365
hm2
 		Mtrtm1Lcb/Mtrtm1Lcb involves: 129S/SvEv * Black Swiss MGI:3036366
ht3
 		Mtrtm1Lcb/Mtr+ 129S/SvEv-Mtrtm1Lcb MGI:2450909
ht4
 		Mtrtm1Lcb/Mtr+ involves: 129S/SvEv * Black Swiss MGI:2450910


Genotype
MGI:3036365
hm1
Allelic
Composition		 Mtrtm1Lcb/Mtrtm1Lcb
Genetic
Background		 129S/SvEv-Mtrtm1Lcb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtrtm1Lcb mutation (0 available); any Mtr mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:67384 )
• homozygous embryos die prior to E9.5




Genotype
MGI:3036366
hm2
Allelic
Composition		 Mtrtm1Lcb/Mtrtm1Lcb
Genetic
Background		 involves: 129S/SvEv * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtrtm1Lcb mutation (0 available); any Mtr mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:67384 )
• homozygous embryos die prior to E9.5




Genotype
MGI:2450909
ht3
Allelic
Composition		 Mtrtm1Lcb/Mtr+
Genetic
Background		 129S/SvEv-Mtrtm1Lcb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtrtm1Lcb mutation (0 available); any Mtr mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating homocysteine level ( J:67384 )
• an elevated level of plasma homocysteine was observed in heterozygotes
increased circulating methionine level ( J:67384 )
• an elevated level of plasma methionine was observed in heterozygotes




Genotype
MGI:2450910
ht4
Allelic
Composition		 Mtrtm1Lcb/Mtr+
Genetic
Background		 involves: 129S/SvEv * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtrtm1Lcb mutation (0 available); any Mtr mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating homocysteine level ( J:67384 )
• an elevated level of plasma homocysteine was observed in heterozygotes
increased circulating methionine level ( J:67384 )
• an elevated level of plasma methionine was observed in heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory