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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itpr1tm1Tno
targeted mutation 1, Tetsuo Noda
MGI:2180360
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itpr1tm1Tno/Itpr1tm1Tno involves: 129S4/SvJae * C57BL/6 MGI:2180389


Genotype
MGI:2180389
hm1
Allelic
Composition
Itpr1tm1Tno/Itpr1tm1Tno
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr1tm1Tno mutation (1 available); any Itpr1 mutation (180 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at postnatal day 10, homozygotes were found with a frequency of only 5.5%
• most homozygous mutant mice die in utero, and some die postnatally

behavior/neurological
• age of onset was P9; more prominent when animals were treated with anticonvulsants for seizures
• truncal contorsions apparent by P15
• tonic clonic seizures prevailing by P20-23

nervous system
• truncal contorsions apparent by P15
• tonic clonic seizures prevailing by P20-23
• overall brain size was decreased to ~40% in weight, but the gross anatomy appeared normal
• the time constant for parallel fiber mediated excitatory post synaptic current (e.p.s.c) decay was significantly shorter in homozygous mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory