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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gy
gyro
MGI:2180359
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gy/Gy B6.Cg-Gy MGI:5009029
hm2
Gy/Gy involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J MGI:5009031
ht3
Gy/Gy+ involves: 101/H * C3H/HeH MGI:5008747
ht4
Gy/Gy+ involves: C3H/Sn * C57BL/6Ei MGI:3037666
ot5
Gy/Y B6.Cg-Gy MGI:5009028
ot6
Gy/Y involves: 101/H * C3H/HeH MGI:5008746
ot7
Gy/Y involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J MGI:5009030
ot8
Gy/Y involves: 101/H * C3H/HeH * C57BL/6J MGI:5009006
ot9
Gy/Y involves: C3H/Sn * C57BL/6Ei MGI:3037661


Genotype
MGI:5009029
hm1
Allelic
Composition
Gy/Gy
Genetic
Background
B6.Cg-Gy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

digestive/alimentary system
• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice




Genotype
MGI:5009031
hm2
Allelic
Composition
Gy/Gy
Genetic
Background
involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

growth/size/body

digestive/alimentary system
• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice




Genotype
MGI:5008747
ht3
Allelic
Composition
Gy/Gy+
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mild in some mice (J:8335)
(J:64263)

hearing/vestibular/ear

growth/size/body

homeostasis/metabolism

limbs/digits/tail

skeleton




Genotype
MGI:3037666
ht4
Allelic
Composition
Gy/Gy+
Genetic
Background
involves: C3H/Sn * C57BL/6Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• all females have a squared trunk

limbs/digits/tail
• shortened hind limbs are seen




Genotype
MGI:5009028
ot5
Allelic
Composition
Gy/Y
Genetic
Background
B6.Cg-Gy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit increased calcium tissue content compared with wild-type mice

digestive/alimentary system
• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice




Genotype
MGI:5008746
ot6
Allelic
Composition
Gy/Y
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

mortality/aging
• sudden

reproductive system

skeleton
• uneven thickness
• uneven thickness
• osteoid seams are widened compared to in wild-type mice

hearing/vestibular/ear
• mice exhibit abnormal vestibular sense organs compared with wild-type mice

behavior/neurological
(J:8335)
(J:64263)

vision/eye

growth/size/body

homeostasis/metabolism
• urinary cAMP is increased compared to in wild-type mice

immune system

nervous system

renal/urinary system
• urinary cAMP is increased compared to in wild-type mice

craniofacial

endocrine/exocrine glands

limbs/digits/tail
• uneven thickness




Genotype
MGI:5009030
ot7
Allelic
Composition
Gy/Y
Genetic
Background
involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit increased calcium tissue content compared with wild-type mice

growth/size/body

digestive/alimentary system
• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice




Genotype
MGI:5009006
ot8
Allelic
Composition
Gy/Y
Genetic
Background
involves: 101/H * C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mice exhibit smaller cranial length, neurocranial length, and length from anterior to posterior palatine foramen compared with wild-type mice
• mice exhibit prominent bulges at the frontonasal suture and the premaxiallary-maxillary suture unlike in wild-type mice

skeleton
• mice exhibit smaller cranial length, neurocranial length, and length from anterior to posterior palatine foramen compared with wild-type mice
• mice exhibit prominent bulges at the frontonasal suture and the premaxiallary-maxillary suture unlike in wild-type mice




Genotype
MGI:3037661
ot9
Allelic
Composition
Gy/Y
Genetic
Background
involves: C3H/Sn * C57BL/6Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (2 available); any Gy mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• a significant increase in lean body mass is seen compared to control

growth/size/body
• all males have significantly lower body weights (~50% less than controls) and a squared trunk
• male Gy mutants weigh significantly less than other PhexHyp male mutants (PhexHyp, PhexHyp-2J, PhexHyp-Duk)

hearing/vestibular/ear
• mean auditory brainstem response thresholds are significantly higher than controls

homeostasis/metabolism
• at 6 weeks of age serum Ca2+ are significantly decreased compared to controls
• at 6 weeks of age serum PO4 levels are significantly lower than controls

limbs/digits/tail
• shortened hind limbs are seen
• the fibula is shortened and splayed
• the tibia is shortened and splayed
• growth plates of the knee are thickened and irregular

skeleton
• growth plates of the knee are thickened and irregular
• disorganized femoral growth plates
• the long bones are shortened
• the fibula is shortened and splayed
• the tibia is shortened and splayed
• the long bones are thickened
• between 6 and 40 weeks of age under-mineralized bone is present throughout the body

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypophosphatemic Rickets, X-Linked Dominant; XLHR 307800 J:38621 , J:88352





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory