All Phenotypes Gy MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gy
gyro
MGI:2180359

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gy/Gy	B6.Cg-Gy	MGI:5009029
hm2	Gy/Gy	involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J	MGI:5009031
ht3	Gy/Gy⁺	involves: 101/H * C3H/HeH	MGI:5008747
ht4	Gy/Gy⁺	involves: C3H/Sn * C57BL/6Ei	MGI:3037666
ot5	Gy/Y	B6.Cg-Gy	MGI:5009028
ot6	Gy/Y	involves: 101/H * C3H/HeH	MGI:5008746
ot7	Gy/Y	involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J	MGI:5009030
ot8	Gy/Y	involves: 101/H * C3H/HeH * C57BL/6J	MGI:5009006
ot9	Gy/Y	involves: C3H/Sn * C57BL/6Ei	MGI:3037661

Allelic Composition	Gy/Gy
Genetic Background	B6.Cg-Gy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating phosphate level ( J:17152 )

digestive/alimentary system

decreased intestinal calcium absorption ( J:17152 )

• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice

Allelic Composition	Gy/Gy
Genetic Background	involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating phosphate level ( J:17152 )

growth/size/body

decreased body weight ( J:17152 )

digestive/alimentary system

decreased intestinal calcium absorption ( J:17152 )

• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice

Allelic Composition	Gy/Gy⁺
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

circling ( J:8335 , J:64263 )

• mild in some mice (J:8335)

(J:64263)

hearing/vestibular/ear

deafness ( J:64263 )

growth/size/body

decreased body weight ( J:8335 )

homeostasis/metabolism

decreased circulating phosphate level ( J:8335 )

limbs/digits/tail

short femur ( J:8335 )

skeleton

short femur ( J:8335 )

Allelic Composition	Gy/Gy⁺
Genetic Background	involves: C3H/Sn * C57BL/6Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:88352 )

• all females have a squared trunk

limbs/digits/tail

short hindlimb ( J:88352 )

• shortened hind limbs are seen

short tail ( J:88352 )

Allelic Composition	Gy/Y
Genetic Background	B6.Cg-Gy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating phosphate level ( J:17152 )

abnormal calcium ion homeostasis ( J:17152 )

• mice exhibit increased calcium tissue content compared with wild-type mice

digestive/alimentary system

decreased intestinal calcium absorption ( J:17152 )

• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice

Allelic Composition	Gy/Y
Genetic Background	involves: 101/H * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:8335 )

• sudden

reproductive system

oligozoospermia ( J:8335 )

decreased testis weight ( J:8335 )

male infertility ( J:8335 )

skeleton

abnormal tooth morphology ( J:8335 )

abnormal long bone morphology ( J:8335 )

• soft

abnormal fibula morphology ( J:8335 )

• uneven thickness

decreased length of long bones ( J:8335 )

increased diameter of long bones ( J:8335 )

abnormal rib morphology ( J:8335 )

• uneven thickness

splayed ribs ( J:8335 )

abnormal osteoid morphology ( J:8335 )

• osteoid seams are widened compared to in wild-type mice

osteomalacia ( J:8335 )

hearing/vestibular/ear

abnormal ear morphology ( J:8335 )

• mice exhibit abnormal vestibular sense organs compared with wild-type mice

abnormal organ of Corti morphology ( J:8335 )

cochlear hair cell degeneration ( J:8335 )

detached tectorial membrane ( J:8335 )

abnormal semicircular canal morphology ( J:8335 )

• stenotic

utricular degeneration ( J:8335 )

vestibular saccular degeneration ( J:8335 )

deafness ( J:64263 )

behavior/neurological

absent pinna reflex ( J:8335 )

impaired righting response ( J:8335 )

• absent

head shaking ( J:8335 )

hyperactivity ( J:8335 )

circling ( J:8335 , J:64263 )

(J:8335)

(J:64263)

vision/eye

blepharitis ( J:8335 )

abnormal eyelid morphology ( J:8335 )

growth/size/body

abnormal head morphology ( J:8335 )

abnormal tooth morphology ( J:8335 )

decreased body size ( J:8335 )

• at P1

decreased body weight ( J:8335 )

homeostasis/metabolism

decreased circulating phosphate level ( J:8335 )

increased circulating alkaline phosphatase level ( J:8335 )

abnormal urine nucleotide level ( J:8335 )

• urinary cAMP is increased compared to in wild-type mice

increased urine phosphate level ( J:8335 )

immune system

blepharitis ( J:8335 )

nervous system

cochlear hair cell degeneration ( J:8335 )

abnormal cochlear nerve morphology ( J:8335 )

renal/urinary system

abnormal urine nucleotide level ( J:8335 )

• urinary cAMP is increased compared to in wild-type mice

increased urine phosphate level ( J:8335 )

craniofacial

abnormal tooth morphology ( J:8335 )

endocrine/exocrine glands

decreased testis weight ( J:8335 )

limbs/digits/tail

abnormal fibula morphology ( J:8335 )

• uneven thickness

cellular

oligozoospermia ( J:8335 )

Allelic Composition	Gy/Y
Genetic Background	involves: 101/H * C3H/HeH * C3H/HeSnJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating phosphate level ( J:17152 )

abnormal calcium ion homeostasis ( J:17152 )

• mice exhibit increased calcium tissue content compared with wild-type mice

growth/size/body

decreased body weight ( J:17152 )

digestive/alimentary system

decreased intestinal calcium absorption ( J:17152 )

• at 4 weeks, mice exhibit reduced calcium absorption in the duodenum compared with wild-type mice

Allelic Composition	Gy/Y
Genetic Background	involves: 101/H * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal cranium morphology ( J:1654 )

• mice exhibit smaller cranial length, neurocranial length, and length from anterior to posterior palatine foramen compared with wild-type mice

abnormal cranial suture morphology ( J:1654 )

• mice exhibit prominent bulges at the frontonasal suture and the premaxiallary-maxillary suture unlike in wild-type mice

decreased cranium height ( J:1654 )

short frontal bone ( J:1654 )

short mandible ( J:1654 )

short premaxilla ( J:1654 )

short nasal bone ( J:1654 )

domed cranium ( J:1654 )

skeleton

abnormal cranium morphology ( J:1654 )

• mice exhibit smaller cranial length, neurocranial length, and length from anterior to posterior palatine foramen compared with wild-type mice

abnormal cranial suture morphology ( J:1654 )

• mice exhibit prominent bulges at the frontonasal suture and the premaxiallary-maxillary suture unlike in wild-type mice

decreased cranium height ( J:1654 )

short frontal bone ( J:1654 )

short mandible ( J:1654 )

short premaxilla ( J:1654 )

short nasal bone ( J:1654 )

domed cranium ( J:1654 )

growth/size/body

short nasal bone ( J:1654 )

respiratory system

short nasal bone ( J:1654 )

Allelic Composition	Gy/Y
Genetic Background	involves: C3H/Sn * C57BL/6Ei

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gy mutation (1 available); any Gy mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:88352 )

• a significant increase in lean body mass is seen compared to control

growth/size/body

decreased body weight ( J:88352 )

• all males have significantly lower body weights (~50% less than controls) and a squared trunk

• male Gy mutants weigh significantly less than other Phex^Hyp male mutants (Phex^Hyp, Phex^Hyp-2J, Phex^Hyp-Duk)

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:88352 )

• mean auditory brainstem response thresholds are significantly higher than controls

homeostasis/metabolism

decreased circulating calcium level ( J:88352 )

• at 6 weeks of age serum Ca²⁺ are significantly decreased compared to controls

decreased circulating potassium level ( J:88352 )

• at 6 weeks of age serum PO₄ levels are significantly lower than controls

limbs/digits/tail

short hindlimb ( J:88352 )

• shortened hind limbs are seen

abnormal limb bone morphology ( J:88352 )

short femur ( J:88352 )

short fibula ( J:88352 )

• the fibula is shortened and splayed

short tibia ( J:88352 )

• the tibia is shortened and splayed

abnormal patella morphology ( J:88352 )

• growth plates of the knee are thickened and irregular

short tail ( J:88352 )

skeleton

abnormal limb bone morphology ( J:88352 )

abnormal patella morphology ( J:88352 )

• growth plates of the knee are thickened and irregular

disorganized long bone epiphyseal plate ( J:88352 )

• disorganized femoral growth plates

decreased length of long bones ( J:88352 )

• the long bones are shortened

short femur ( J:88352 )

short fibula ( J:88352 )

• the fibula is shortened and splayed

short tibia ( J:88352 )

• the tibia is shortened and splayed

increased diameter of long bones ( J:88352 )

• the long bones are thickened

decreased bone mineral density ( J:88352 )

• between 6 and 40 weeks of age under-mineralized bone is present throughout the body

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
X-linked dominant hypophosphatemic rickets		DOID:0050445	OMIM:307800	J:38621 , J:88352

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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