Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation
(1 available);
any
Nfkb2 mutation
(49 available)
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hematopoietic system
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• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells
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immune system
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• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation
(1 available);
any
Nfkb2 mutation
(49 available)
|
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immune system
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• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
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• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
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• 50% to 80% in the spleen as early as 1 week after birth
• the number of B cells in the bone marrow declines 50% between 8 and 12 weeks unlike in wild-type mice
• however, both mature and immature B cells are detected
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• spleen architecture is disrupted with diffuse, irregular B cell areas and absent perifollicular marginal zone and germinal centers unlike in wild-type mice
• sheep red blood cell-imminized mice exhibit very few germinal center cells and diffuse perifollicular staining of cells expressing surface IgD unlike in similarly treated wild-type mice
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• sheep red blood cell-imminized mice exhibit reduced numbers of metallophillic macrophages scattered throughout the white matter unlike in similarly treated wild-type mice
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• in mice immunized with a variety of antigens, including sheep red blood cells and NP-KLH
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• following immunization with NP-KLH, mice exhibit a 4-fold and 10-fold reduction at days 7 and 10, respectively, in NP-specific isotype IgG1 compared to in similarly treated wild-type mice
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• 2.5-fold in naive cells
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• in naive cells, IgG3 is reduced 3-fold compared to in wild-type mice
• following immunization with NP-LPS, mice exhibit a 10-fold and 30-fold reduction at days 7 and 21, respectively, in NP-specific IgG3 compared to in similarly treated wild-type mice
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• 4.5-fold in naive cells and 2 times higher in response to distinct stimuli compared to in wild-type mice
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• lymph nodes exhibit similar morphological abnormalities as those observed in the spleen
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hematopoietic system
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• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
|
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• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
|
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• 50% to 80% in the spleen as early as 1 week after birth
• the number of B cells in the bone marrow declines 50% between 8 and 12 weeks unlike in wild-type mice
• however, both mature and immature B cells are detected
|
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• spleen architecture is disrupted with diffuse, irregular B cell areas and absent perifollicular marginal zone and germinal centers unlike in wild-type mice
• sheep red blood cell-imminized mice exhibit very few germinal center cells and diffuse perifollicular staining of cells expressing surface IgD unlike in similarly treated wild-type mice
|
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• sheep red blood cell-imminized mice exhibit reduced numbers of metallophillic macrophages scattered throughout the white matter unlike in similarly treated wild-type mice
|
|
• in mice immunized with a variety of antigens, including sheep red blood cells and NP-KLH
|
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• following immunization with NP-KLH, mice exhibit a 4-fold and 10-fold reduction at days 7 and 10, respectively, in NP-specific isotype IgG1 compared to in similarly treated wild-type mice
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• 2.5-fold in naive cells
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• in naive cells, IgG3 is reduced 3-fold compared to in wild-type mice
• following immunization with NP-LPS, mice exhibit a 10-fold and 30-fold reduction at days 7 and 21, respectively, in NP-specific IgG3 compared to in similarly treated wild-type mice
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• 4.5-fold in naive cells and 2 times higher in response to distinct stimuli compared to in wild-type mice
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cellular
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• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
|
|
• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation
(1 available);
any
Nfkb2 mutation
(49 available)
Tg(Tnfsf13b)1Fma mutation
(0 available)
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immune system
N |
• there are no elevated levels of anti-dsDNA antibodies detected in circulation compared to transgenic mice on a wild-type background that have high levels of auto-antbodies
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• marginal zone B cells are almost completely absent in the spleen
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• marginal zones are absent in these mice
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• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls
• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background
• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background
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homeostasis/metabolism
renal/urinary system
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• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration
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hematopoietic system
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• marginal zone B cells are almost completely absent in the spleen
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• marginal zones are absent in these mice
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• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls
• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background
• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation
(1 available);
any
Nfkb2 mutation
(49 available)
Traf3tm1Bal mutation
(0 available);
any
Traf3 mutation
(42 available)
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mortality/aging
N |
• unlike Traf3tm1Bal homozygotes, mice survive into adulthood
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immune system
N |
• mice do not exhibit the immune defects observed in single homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation
(1 available);
any
Nfkb2 mutation
(49 available)
Traf3tm1Bal mutation
(0 available);
any
Traf3 mutation
(42 available)
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mortality/aging
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• unlike Traf3tm1Bal homozygotes, mice survive until 18 days
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