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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nfkb2tm2Brv
targeted mutation 2, Rodrigo Bravo
MGI:2180306
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nfkb2tm2Brv/Nfkb2tm2Brv involves: 129S1/Sv MGI:5441220
hm2
Nfkb2tm2Brv/Nfkb2tm2Brv involves: 129S1/Sv * C57BL/6 MGI:4352675
cx3
Nfkb2tm2Brv/Nfkb2tm2Brv
Tg(Tnfsf13b)1Fma/?
B6.Cg-Nfkb2tm2Brv Tg(Tnfsf13b)1Fma MGI:3841109
cx4
Nfkb2tm2Brv/Nfkb2tm2Brv
Traf3tm1Bal/Traf3tm1Bal
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 MGI:4352677
cx5
Nfkb2tm2Brv/Nfkb2+
Traf3tm1Bal/Traf3tm1Bal
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 MGI:4352678


Genotype
MGI:5441220
hm1
Allelic
Composition
Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation (1 available); any Nfkb2 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells

immune system
• reduced IL17-expressing splenic gamma-delta T cells and Vgamma4 gamma-delta T cells




Genotype
MGI:4352675
hm2
Allelic
Composition
Nfkb2tm2Brv/Nfkb2tm2Brv
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation (1 available); any Nfkb2 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
• 50% to 80% in the spleen as early as 1 week after birth
• the number of B cells in the bone marrow declines 50% between 8 and 12 weeks unlike in wild-type mice
• however, both mature and immature B cells are detected
• spleen architecture is disrupted with diffuse, irregular B cell areas and absent perifollicular marginal zone and germinal centers unlike in wild-type mice
• sheep red blood cell-imminized mice exhibit very few germinal center cells and diffuse perifollicular staining of cells expressing surface IgD unlike in similarly treated wild-type mice
• sheep red blood cell-imminized mice exhibit reduced numbers of metallophillic macrophages scattered throughout the white matter unlike in similarly treated wild-type mice
• in mice immunized with a variety of antigens, including sheep red blood cells and NP-KLH
• 2-fold in naive cell
• following immunization with NP-KLH, mice exhibit a 4-fold and 10-fold reduction at days 7 and 10, respectively, in NP-specific isotype IgG1 compared to in similarly treated wild-type mice
• 2.5-fold in naive cells
• in naive cells, IgG3 is reduced 3-fold compared to in wild-type mice
• following immunization with NP-LPS, mice exhibit a 10-fold and 30-fold reduction at days 7 and 21, respectively, in NP-specific IgG3 compared to in similarly treated wild-type mice
• 4.5-fold in naive cells and 2 times higher in response to distinct stimuli compared to in wild-type mice
• lymph nodes exhibit similar morphological abnormalities as those observed in the spleen

hematopoietic system
• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5
• 50% to 80% in the spleen as early as 1 week after birth
• the number of B cells in the bone marrow declines 50% between 8 and 12 weeks unlike in wild-type mice
• however, both mature and immature B cells are detected
• spleen architecture is disrupted with diffuse, irregular B cell areas and absent perifollicular marginal zone and germinal centers unlike in wild-type mice
• sheep red blood cell-imminized mice exhibit very few germinal center cells and diffuse perifollicular staining of cells expressing surface IgD unlike in similarly treated wild-type mice
• sheep red blood cell-imminized mice exhibit reduced numbers of metallophillic macrophages scattered throughout the white matter unlike in similarly treated wild-type mice
• in mice immunized with a variety of antigens, including sheep red blood cells and NP-KLH
• 2-fold in naive cell
• following immunization with NP-KLH, mice exhibit a 4-fold and 10-fold reduction at days 7 and 10, respectively, in NP-specific isotype IgG1 compared to in similarly treated wild-type mice
• 2.5-fold in naive cells
• in naive cells, IgG3 is reduced 3-fold compared to in wild-type mice
• following immunization with NP-LPS, mice exhibit a 10-fold and 30-fold reduction at days 7 and 21, respectively, in NP-specific IgG3 compared to in similarly treated wild-type mice
• 4.5-fold in naive cells and 2 times higher in response to distinct stimuli compared to in wild-type mice

cellular
• more cells in the white pulp undergo apoptosis than in wild-type mice
• however, stimulated B cells in the spleen exhibit normal levels of apoptosis
• in LPS, anti-IgD-dextran, and anti-CD40 treated cells in the presence of IL4 and IL5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
common variable immunodeficiency DOID:12177 OMIM:PS607594
J:206674




Genotype
MGI:3841109
cx3
Allelic
Composition
Nfkb2tm2Brv/Nfkb2tm2Brv
Tg(Tnfsf13b)1Fma/?
Genetic
Background
B6.Cg-Nfkb2tm2Brv Tg(Tnfsf13b)1Fma
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation (1 available); any Nfkb2 mutation (49 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• there are no elevated levels of anti-dsDNA antibodies detected in circulation compared to transgenic mice on a wild-type background that have high levels of auto-antbodies
• marginal zone B cells are almost completely absent in the spleen
• marginal zones are absent in these mice
• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls
• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background
• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background

homeostasis/metabolism
• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration

renal/urinary system
• about half of 8-month old mice have proteinuria in their urine at 30 mg/dl concentration

hematopoietic system
• marginal zone B cells are almost completely absent in the spleen
• marginal zones are absent in these mice
• B cells have a strong response to T cell independent antigens producing higher levels of antigen-specific IgM, IgG2a, IgG2b class antibodies than wild-type controls
• however, there is no significant elevation of antigen-specific IgG1, IgG3, and IgA antibodies as is observed in transgenic mice on a wild-type background
• levels of antibodies produced are also lower than those in transgenic mice on a wild-type background




Genotype
MGI:4352677
cx4
Allelic
Composition
Nfkb2tm2Brv/Nfkb2tm2Brv
Traf3tm1Bal/Traf3tm1Bal
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation (1 available); any Nfkb2 mutation (49 available)
Traf3tm1Bal mutation (0 available); any Traf3 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike Traf3tm1Bal homozygotes, mice survive into adulthood

immune system
N
• mice do not exhibit the immune defects observed in single homozygotes




Genotype
MGI:4352678
cx5
Allelic
Composition
Nfkb2tm2Brv/Nfkb2+
Traf3tm1Bal/Traf3tm1Bal
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb2tm2Brv mutation (1 available); any Nfkb2 mutation (49 available)
Traf3tm1Bal mutation (0 available); any Traf3 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• unlike Traf3tm1Bal homozygotes, mice survive until 18 days





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory