Phenotypes associated with this allele

• Allele Symbol: Defb1^tm1Jmw
• Allele Name: targeted mutation 1, James M Wilson
• Allele ID: MGI:2180305
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Defb1^tm1Jmw/Defb1^tm1Jmw	B6.129S5-Defb1^tm1Jmw	MGI:3845196
ht2	Defb1^tm1Jmw/Defb1^+	B6.129S5-Defb1^tm1Jmw	MGI:3845197

Genotype
MGI:3845196

hm1

• Allelic Composition: Defb1^tm1Jmw/Defb1^tm1Jmw
• Genetic Background: B6.129S5-Defb1^tm1Jmw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:76529 )

• fewer than expected mice are generated

immune system

increased susceptibility to bacterial infection ( J:76529 )

• following infection with high doses of H. influenzae type b strain Eagan, bacterial clearance is less than in similarly treated wild-type mice

• however, mice exhibit normal pathological changes following H. influenzae and normal lethality in response to S. pneumoniae D39 type 2 infection

Genotype
MGI:3845197

ht2

• Allelic Composition: Defb1^tm1Jmw/Defb1⁺
• Genetic Background: B6.129S5-Defb1^tm1Jmw

immune system

increased susceptibility to bacterial infection ( J:76529 )

• following infection with high doses of H. influenzae type b strain Eagan, bacterial clearance is slightly less than in similarly treated wild-type mice

• however, mice exhibit normal bacterial clearance following infection with lose doses of bacteria