Phenotypes associated with this allele

• Allele Symbol: Ccl5^tm1Hso
• Allele Name: targeted mutation 1, Hiroshi Sato
• Allele ID: MGI:2180195
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl5^tm1Hso/Ccl5^tm1Hso	involves: 129P2/OlaHsd * C57BL/6	MGI:2660697

Genotype
MGI:2660697

hm1

• Allelic Composition: Ccl5^tm1Hso/Ccl5^tm1Hso
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:75842 )

• polyclonal T cell proliferation (anti-CD3 mAb-induced) and antigen-specific T cell proliferation (KLH-induced) are reduced

• anti-CD3 mAb-induced lymph node T cell proliferation from unprimed mice is also reduced

• T cells from draining lymph nodes of KLH-immunized mice mixed with irradiated splenocytes (source of APCs) show a reduced proliferative capacity

decreased CD4-positive, alpha-beta T cell number ( J:75842 )

• percentage of CD44 high and CD62L low CD4+ cells is decreased by 24% and 14%, respectively, in the spleen

decreased susceptibility to type IV hypersensitivity reaction ( J:75842 )

• mutants show reduced delayed-type hypersensitivity response, with reduced KLH-specific swelling in both the ears and footpads, much milder dermal edema and inflammatory infiltrates than wild-type, and significant reduction in macrophage accumulation in footpads

decreased interferon-gamma secretion ( J:75842 )

• T cells from KLH-immunized mice show a 76% reduction in IFN-gamma production when stimulated with anti-CD3 mAb and a 49% reduction when stimulated with KLH

decreased interleukin-2 secretion ( J:75842 )

• T cells from KLH-immunized mice show a reduction in IL-2 production when stimulated with anti-CD3 mAb

hematopoietic system

decreased T cell proliferation ( J:75842 )

• polyclonal T cell proliferation (anti-CD3 mAb-induced) and antigen-specific T cell proliferation (KLH-induced) are reduced

• anti-CD3 mAb-induced lymph node T cell proliferation from unprimed mice is also reduced

• T cells from draining lymph nodes of KLH-immunized mice mixed with irradiated splenocytes (source of APCs) show a reduced proliferative capacity

decreased CD4-positive, alpha-beta T cell number ( J:75842 )

• percentage of CD44 high and CD62L low CD4+ cells is decreased by 24% and 14%, respectively, in the spleen

cellular

decreased T cell proliferation ( J:75842 )

• polyclonal T cell proliferation (anti-CD3 mAb-induced) and antigen-specific T cell proliferation (KLH-induced) are reduced

• anti-CD3 mAb-induced lymph node T cell proliferation from unprimed mice is also reduced

• T cells from draining lymph nodes of KLH-immunized mice mixed with irradiated splenocytes (source of APCs) show a reduced proliferative capacity