Analysis Tools
growth/size/body
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• body weight is decreased on a normal chow diet
• on a high fat diet homozygotes gain less weight (body weight increase of 8.44% compared to 15.83 for wild-type mice) despite having similar total caloric intake compared to wild-type mice
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• on a high fat diet homozygotes remain lean unlike wild-type mice
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homeostasis/metabolism
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• on a high fat diet homozygotes remain lean unlike wild-type mice
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• on a high fat diet fasting insulin levels are lower in homozygotes compared to wild-type mice on the same diet, no difference is seen on a normal chow diet
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• under fasting conditions; however plasma leptin levels are normal
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• under fasting conditions
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• glucose clearance is increased during oral or i.p. glucose tolerance tests compared to age, sex, and weight matched wild-type mice
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• at lower doses of insulin the drop in blood glucose is increased in homozygotes and during euglycemic clamp assays glucose infusion rates were higher in homozygotes
• increased insulin sensitivity is seen on both normal and high fat diets
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