Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora1tm1Bbf mutation
(1 available);
any
Adora1 mutation
(22 available)
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behavior/neurological
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• in the complete Freund's adjuvant model of chronic inflammatory pain or in the spared nerve injury model of neuropathic pain, mice injected with human ACPP exhibit increased mechanical allodynia compared with wild-type mice
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• in mice injected with human ACPP
• in mice injected with human ACPP in the complete Freund's adjuvant model of chronic inflammatory pain or in the spared nerve injury model of neuropathic pain
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora1tm1Bbf mutation
(1 available);
any
Adora1 mutation
(22 available)
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homeostasis/metabolism
behavior/neurological
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• homozygotes display increased anxiety in the dark-light box test, with a significantly reduced number of entries into as well as less total time spent in the lit compartment
• however, visual placing reflex, equilibrium, prehensility or total activity over a 24-h period are normal
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• homozygotes exhibit thermal (but not mechanical) hyperalgesia relative to wild-type or heterozygous mice
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• homozygotes react faster to thermal pain, as shown by significanlty reduced latencies under basal conditions or after intrathecal administration of adenosine analogue R-PIA in the tail-flick test
• i.p. administration of morphine (5 mg/kg) has no effect on thermal nociception
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cardiovascular system
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• homozygotes show no significant differences in heart rate or blood pressure relative to wild-type mice
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nervous system
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• homozygotes display complete loss of both adenosine-mediated inhibition and theophylline-mediated augmentation of excitatory glutamatergic neurotransmission
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• electrophysiological recordings from hippocampal slices indicate that homozygotes fail to exhibit adenosine-mediated inhibition of EPSCs
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• electrophysiological recordings from hippocampal slices indicate that homozygotes fail to exhibit adenosine-mediated inhibition of fEPSPs
• in response to hypoxia/anoxia, homozygotes show a significantly delayed and attenuated inhibition of fEPSP responses in hippocampal slices, with no recovery after 60 min of incubation in hypoxic buffer
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• homozygotes exhibit a reduced response to hypoxia/anoxia, with mutant hippocampal slices exhibiting a delayed and attenuated decrease in synaptic transmission relative to wild-type slices
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respiratory system
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• in reponse to hypoxia, brainstem spinal cord preparations from wild-type mice show a decrease in respiratory output within 3 min after the onset of hypoxia, with full recovery of the respiratory rhythm and brainstem neuronal activity upon reintroduction of oxygenated medium; in mutant preparations, the depression in respiratory output is significantly delayed and full recovery is not attained
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adora1tm1Bbf mutation
(1 available);
any
Adora1 mutation
(22 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adktm2Bois mutation
(0 available);
any
Adk mutation
(50 available)
Adora1tm1Bbf mutation
(1 available);
any
Adora1 mutation
(22 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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behavior/neurological
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• mice exhibit increased susceptibility to stress-induced (placement in novel environment) seizures
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mortality/aging
nervous system
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• mice exhibit increased susceptibility to stress-induced (placement in novel environment) seizures
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Analysis Tools