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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adh7tm1Gdu
targeted mutation 1, Gregg Duester
MGI:2180102
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adh7tm1Gdu/Adh7tm1Gdu B6.129(Cg)-Adh7tm1Gdu MGI:4936868
hm2
Adh7tm1Gdu/Adh7tm1Gdu involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:2447868
ht3
Adh7tm1Gdu/Adh7+ B6.129(Cg)-Adh7tm1Gdu MGI:4936869
cx4
Adh1tm2Gdu/Adh1tm2Gdu
Adh7tm1Gdu/Adh7tm1Gdu
involves: 129S1/Sv * 129X1/SvJ * Black Swiss MGI:3845829


Genotype
MGI:4936868
hm1
Allelic
Composition
Adh7tm1Gdu/Adh7tm1Gdu
Genetic
Background
B6.129(Cg)-Adh7tm1Gdu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh7tm1Gdu mutation (1 available); any Adh7 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mutants exhibit normal spontaneous rearing, motility and locomotion
• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice
• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice
• administration of D-amphetamine significantly increases the motility and locomotion of 12-17 month old male mutants compared to wild-type mice
• administration of apomorphine results in a higher response in horizontal movement in 12-17 month old mutants than in wild-type mice

growth/size/body
• males exhibit a lower weight than controls at 12-17 months of age

nervous system
• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra
• significantly increased levels of the monoamine metabolite, DOPAC are observed in the olfactory bulb, however levels of dopamine are normal

taste/olfaction
• 18-20 month old mutants exhibit impaired olfaction, with mice showing longer times to find an odor target than wild-type mice

homeostasis/metabolism
• levels of dopamine and dopamine dihydroxyphenylacetic acid (DOPAC), a monoamine metabolite, are increased in the substantia nigra

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:167234




Genotype
MGI:2447868
hm2
Allelic
Composition
Adh7tm1Gdu/Adh7tm1Gdu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh7tm1Gdu mutation (1 available); any Adh7 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• retinol toxicity is increased in these mice with a LD50 that is 1.6-fold less than controls

homeostasis/metabolism
• retinol-treated mutants have significantly lower levels of kidney retinoic acid than wild-type
• increase in ethanol-induced embryo resorption during pregnancy compared to controls (J:55555)
• defective ethanol clearance (J:56168)
• reduced metabolism of retinal to retinoic acid (J:56168)
• retinol toxicity is increased in these mice with a LD50 that is 1.6-fold less than controls (J:76055)




Genotype
MGI:4936869
ht3
Allelic
Composition
Adh7tm1Gdu/Adh7+
Genetic
Background
B6.129(Cg)-Adh7tm1Gdu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh7tm1Gdu mutation (1 available); any Adh7 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• administration of D-amphetamine significantly increases the motility of mutants compared to wild-type
• administration of D-amphetamine significantly increases the motility of mutants compared to wild-type
• heterozygotes exhibit a decrease in spontaneous rearing, but no differences in motility or locomotion




Genotype
MGI:3845829
cx4
Allelic
Composition
Adh1tm2Gdu/Adh1tm2Gdu
Adh7tm1Gdu/Adh7tm1Gdu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh1tm2Gdu mutation (0 available); any Adh1 mutation (32 available)
Adh7tm1Gdu mutation (1 available); any Adh7 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exposed to vitamin A deficiency in utero start dying during the postnatal period with all mice dead by 25 days of age

homeostasis/metabolism
• following administration of a 50-mg/kg dose of retinol, there is a 10-fold decrease in retinoic acid production in the liver and a 23-fold drop in the sera compared to wild-type mice
• retinol toxicity is increased in these mice with a LD50 that is 2.2-fold less than controls

growth/size/body
• mice exposed to vitamin A deficiency in utero have bodyweight that deviate downward from WT at 8 days of age
• body weights beyond 6 g were not achieved before death





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory