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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adcyap1r1tm1Bbt
targeted mutation 1, Philippe Brabet
MGI:2180097
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt involves: 129 * C57BL/6J MGI:2447790
ht2
 		Adcyap1r1tm1Bbt/Adcyap1r1+ involves: 129 * C57BL/6J MGI:3615332


Genotype
MGI:2447790
hm1
Allelic
Composition		 Adcyap1r1tm1Bbt/Adcyap1r1tm1Bbt
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcyap1r1tm1Bbt mutation (0 available); any Adcyap1r1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:62115 )
• 60% loss of pups after birth until 4 weeks postnatal, no loss thereafter

behavior/neurological
shortened circadian behavior period ( J:70076 )
• under constant darkness
delayed circadian behavior phase ( J:70076 )
• longer phase delay in locomotor activity after light pulse in early evening vs. wild-type

growth/size/body
decreased body weight ( J:62115 )
• adult females had weak, but significant decreased body weight vs. wild-type littermates

homeostasis/metabolism
decreased circulating insulin level ( J:62115 )
• in glucose tolerance tests
increased circulating insulin level ( J:62115 )
• mild, in fed state
impaired glucose tolerance ( J:62115 )
• decreased glucose clearance in glucose tolerance tests

immune system
increased susceptibility to bacterial infection ( J:73990 )
• increased mortality in LPS-induced endotoxemia

reproductive system
prolonged diestrus ( J:105125 )
• a longer and irregular diestrus was observed
prolonged estrous cycle ( J:105125 )
• the oestrus cycle lasted more than 4 days
reduced female fertility ( J:105125 )
• pairings produced one-third the number of litters produced by wildtype matings




Genotype
MGI:3615332
ht2
Allelic
Composition		 Adcyap1r1tm1Bbt/Adcyap1r1+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcyap1r1tm1Bbt mutation (0 available); any Adcyap1r1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:105125 )
• paired heterozygous matings produced half the number of litters as did wildtype maitngs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory