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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nefltm1Jpj
targeted mutation 1, Jean-Pierre Julien
MGI:2180095
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nefltm1Jpj/Nefltm1Jpj involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3527973
cx2
Nefltm1Jpj/Nefltm1Jpj
Tg(SOD1*G85R)148Dwc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3527974


Genotype
MGI:3527973
hm1
Allelic
Composition
Nefltm1Jpj/Nefltm1Jpj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nefltm1Jpj mutation (0 available); any Nefl mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• density of microtubules increased dramatically
• intermediate filament structures scarce in the axons of adults but present in new born mice
• large myelinated fibers of much smaller diameter than normal
• leads to a unimodal rather than bimodal size distribution
• myelin sheaths are normal even though the axonal diameter is smaller
• after sciatic or facial nerve crush, the number of regenerating axons was considerably reduced
• considerable growth was seen by 2 months after nerve crush however
• axonal profile is similar to NF-H/NF-M mutants; reduction in ventral root axonal caliber is similar




Genotype
MGI:3527974
cx2
Allelic
Composition
Nefltm1Jpj/Nefltm1Jpj
Tg(SOD1*G85R)148Dwc/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nefltm1Jpj mutation (0 available); any Nefl mutation (7 available)
Tg(SOD1*G85R)148Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 12 months of age, no axon loss or degeneration in motor nerves
• mice start out with a 13% reduction of motor neurons
• further degeneration is delayed but ultimately reaches the same level of motor axon loss
• loss of axons in sensory neurons is increased
• slower development of ALS symptoms than in the presence of the transgene alone





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory