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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Acadvltm1Uab
targeted mutation 1, University of Alabama
MGI:2180080
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Acadvltm1Uab/Acadvltm1Uab involves: 129S6/SvEvTac * C57BL/6 MGI:2446598
cx2
Acadltm1Uab/Acadltm1Uab
Acadvltm1Uab/Acadvltm1Uab
involves: 129S6/SvEvTac * C57BL/6NTac MGI:3829074


Genotype
MGI:2446598
hm1
Allelic
Composition
Acadvltm1Uab/Acadvltm1Uab
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acadvltm1Uab mutation (1 available); any Acadvl mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• C16 and C18 acylcarnitines are elevated in bile, blood, and serum of fasted mutants
• mild lipid accumulation in the heart is seen in fasted mutants
• mild reduction in mitochondrial acyl-CoA dehydrogenase activity toward palmitoyl-CoA and oleoyl-CA in the liver

liver/biliary system
• fasted mice display mild steatosis, with droplets of varying sizes in many hepatocytes

cardiovascular system
• fasted mice display a mild, diffuse fatty change in hearts




Genotype
MGI:3829074
cx2
Allelic
Composition
Acadltm1Uab/Acadltm1Uab
Acadvltm1Uab/Acadvltm1Uab
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acadltm1Uab mutation (1 available); any Acadl mutation (9 available)
Acadvltm1Uab mutation (1 available); any Acadvl mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• partially cannibalized pups are observed, indicating loss occurs as late as the periparturient period





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory