homeostasis/metabolism

increased circulating carnitine level ( J:72193 )

• C16 and C18 acylcarnitines are elevated in bile, blood, and serum of fasted mutants

abnormal lipid homeostasis ( J:72193 )

• mild lipid accumulation in the heart is seen in fasted mutants

abnormal enzyme/coenzyme activity ( J:72193 )

• mild reduction in mitochondrial acyl-CoA dehydrogenase activity toward palmitoyl-CoA and oleoyl-CA in the liver

liver/biliary system

hepatic steatosis ( J:72193 )

• fasted mice display mild steatosis, with droplets of varying sizes in many hepatocytes

cardiovascular system

abnormal heart morphology ( J:72193 )

• fasted mice display a mild, diffuse fatty change in hearts

Mouse Models of Human Disease		OMIM ID	Ref(s)
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of; ACADVLD		201475	J:72193