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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk11tm1Mmt
targeted mutation 1, Makoto M Taketo
MGI:2180012
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stk11tm1Mmt/Stk11tm1Mmt involves: 129X1/SvJ MGI:3851986
ht2
 		Stk11tm1Mmt/Stk11+ involves: 129X1/SvJ MGI:3851987
cx3
 		Stk11tm1Mmt/Stk11+
Trp53tm1Brd/Trp53tm1Brd 		involves: 129S7/SvEvBrd * 129X1/SvJ MGI:3851991
cx4
 		Stk11tm1Mmt/Stk11+
Trp53tm1Brd/Trp53+ 		involves: 129S7/SvEvBrd * 129X1/SvJ MGI:3851992


Genotype
MGI:3851986
hm1
Allelic
Composition		 Stk11tm1Mmt/Stk11tm1Mmt
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11tm1Mmt mutation (0 available); any Stk11 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:76202 )
• no pups are recovered indicating embryonic lethality




Genotype
MGI:3851987
ht2
Allelic
Composition		 Stk11tm1Mmt/Stk11+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11tm1Mmt mutation (0 available); any Stk11 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:76202 )
• some mice die after 50 weeks while others survive beyond 70 weeks

neoplasm
increased tumor incidence ( J:76202 )
• tumor cells proliferate continuously in the polyps
increased hepatocellular carcinoma incidence ( J:76202 )
• after 30 weeks in most mice
increased hamartoma incidence ( J:76202 , J:107275 )
• polyps exhibit characteristics of hamartomas (J:76202)
• after 20 weeks, mice develop gastric hamartomas unlike wild-type mice (J:107275)
• hamartomas are composed of glandular and cystic epithelial layers without dysplastic signs (J:107275)

digestive/alimentary system
gastric polyps ( J:76202 )
• after 20 weeks, 93% of mice develop gastric polyps unlike wild-type mice
• after 40 weeks, all mice develop gastric polyps unlike in wild-type mice
• polyps develop in the glandular stomach and small intestine of older mice
• after 50 weeks, 31% of mice develop small intestinal polyps unlike wild-type mice
• small polyps are sessile while larger ones are pedunculated and consist of glandular and cystic epithelial layers

liver/biliary system
increased hepatocellular carcinoma incidence ( J:76202 )
• after 30 weeks in most mice




Genotype
MGI:3851991
cx3
Allelic
Composition		 Stk11tm1Mmt/Stk11+
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11tm1Mmt mutation (0 available); any Stk11 mutation (34 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:107275 )
• mice by at 7 months

neoplasm
increased tumor incidence ( J:107275 )
• at 25 weeks, one mouse develops bladder tumor unlike wild-type mice
increased ovary tumor incidence ( J:107275 )
• in two mice at 30 weeks
increased liver tumor incidence ( J:107275 )
• 12 mice develop hepatic nodular foci unlike in wild-type mice
increased hepatocellular carcinoma incidence ( J:107275 )
• between 25 and 30 weeks in one mouse
increased hamartoma incidence ( J:107275 )
• after 12 weeks, all mice develop gastric hamartomas unlike wild-type mice

liver/biliary system
abnormal hepatocyte morphology ( J:107275 )
• enlarged and dysplastic in nodules
increased liver tumor incidence ( J:107275 )
• 12 mice develop hepatic nodular foci unlike in wild-type mice
increased hepatocellular carcinoma incidence ( J:107275 )
• between 25 and 30 weeks in one mouse

reproductive system
increased ovary tumor incidence ( J:107275 )
• in two mice at 30 weeks

endocrine/exocrine glands
increased ovary tumor incidence ( J:107275 )
• in two mice at 30 weeks




Genotype
MGI:3851992
cx4
Allelic
Composition		 Stk11tm1Mmt/Stk11+
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11tm1Mmt mutation (0 available); any Stk11 mutation (34 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hamartoma incidence ( J:107275 )
• after 20 weeks, mice develop gastric hamartomas unlike wild-type mice
• at 24 weeks, all mice develop gastric hamartomas unlike wild-type mice
• hamartomas are composed of glandular and cystic epithelial layers without dysplastic signs




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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory