About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgap5tm1Jset
targeted mutation 1, Jeffrey Settleman
MGI:2179998
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgap5tm1Jset/Arhgap5tm1Jset involves: 129S2/SvPas * C57BL/6J MGI:3652841
ht2
 		Arhgap5tm1Jset/Arhgap5+ involves: 129S2/SvPas * C57BL/6 MGI:3652862


Genotype
MGI:3652841
hm1
Allelic
Composition		 Arhgap5tm1Jset/Arhgap5tm1Jset
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap5tm1Jset mutation (0 available); any Arhgap5 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:76484 )
• die immediately after birth

growth/size/body
decreased body size ( J:76484 )
• 30% reduction in body size

nervous system
abnormal brain commissure morphology ( J:76484 )
• severe reduction in the major midline forebrain crossing tracts (corpus callosum and anterior commissure)
thin cerebral cortex ( J:76484 )
• thinner cortex associated with partial loss of cortical axon tracts

respiratory system
abnormal respiration ( J:76484 )
• lungs fail to inflate properly at birth

hematopoietic system
small thymus ( J:76484 )
• seen at birth

immune system
small thymus ( J:76484 )
• seen at birth

adipose tissue
decreased subcutaneous adipose tissue amount ( J:83120 )
• newborns exhibit a reduction in subcutaneous fat in dermal tissue
abnormal adipose tissue physiology ( J:83120 )
• MEF cultures are significantly impaired in their ability to undergo adipogenic conversion and to differentiate into adipocytes and instead undergo myogenic differentiation

integument
decreased subcutaneous adipose tissue amount ( J:83120 )
• newborns exhibit a reduction in subcutaneous fat in dermal tissue

endocrine/exocrine glands
small thymus ( J:76484 )
• seen at birth




Genotype
MGI:3652862
ht2
Allelic
Composition		 Arhgap5tm1Jset/Arhgap5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap5tm1Jset mutation (0 available); any Arhgap5 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland development ( J:83627 )
• virgin females exhibit significantly retarded mammary ductal growth at 3, 4, and 5 weeks of age
• exhibit a decrease in the proliferation of Cap cells of terminal end buds at 5 weeks of age

integument
abnormal mammary gland development ( J:83627 )
• virgin females exhibit significantly retarded mammary ductal growth at 3, 4, and 5 weeks of age
• exhibit a decrease in the proliferation of Cap cells of terminal end buds at 5 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory