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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Xrcc5tm1Dbr
targeted mutation 1, David B Roth
MGI:2179987
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Xrcc5tm1Dbr/Xrcc5tm1Dbr involves: 129S1/Sv * C57BL/6 MGI:3639043
hm2
Xrcc5tm1Dbr/Xrcc5tm1Dbr involves: 129S6/SvEvTac * C57BL/6 MGI:3655990
hm3
Xrcc5tm1Dbr/Xrcc5tm1Dbr Not Specified MGI:5013937
ht4
Xrcc5tm1Dbr/Xrcc5+ involves: 129S6/SvEvTac * C57BL/6 MGI:3655989
cx5
Xrcc5tm1Dbr/Xrcc5+
Lig4tm1Fwa/Lig4+
involves: 129S6/SvEvTac * C57BL/6 MGI:3655987
cx6
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Lig4tm1Fwa/Lig4tm1Fwa
involves: 129S6/SvEvTac * C57BL/6 MGI:3655986
cx7
Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL MGI:3818750
cx8
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL MGI:3818751
cx9
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
involves: 129S7/SvEvBrd * C57BL MGI:3818748


Genotype
MGI:3639043
hm1
Allelic
Composition
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice have a profoundly hypocellular thymus with 50- 170-fold fewer cells than controls
• mice display defective coding joint formation; Ig heavy chain rearrangements are decreased by ~10-fold compared to wild-type
• mice display defective signal joint formation
• B cells development is arrested at at the pro-B cell stage
• over 90% of thymocytes are double-negative compared to only 5-10% of wild-type
• thymocytes from 10 week-old mice are arrested at the CD4-CD8-CD25+ stage
• no mature T cells are detected in mutants
• lymph nodes are hypocellular and difficult to recover

hematopoietic system
• mice have a profoundly hypocellular thymus with 50- 170-fold fewer cells than controls
• mice display defective coding joint formation; Ig heavy chain rearrangements are decreased by ~10-fold compared to wild-type
• mice display defective signal joint formation
• B cells development is arrested at at the pro-B cell stage
• over 90% of thymocytes are double-negative compared to only 5-10% of wild-type
• thymocytes from 10 week-old mice are arrested at the CD4-CD8-CD25+ stage
• no mature T cells are detected in mutants

vision/eye
• embryonic mice show increased (~5-fold) retinal apoptosis compared to wild-type
• number of neuronal retinal nuclei is decreased compare to wild-type when quantified between 2 and 8 months of age

cellular
• embryonic mice show increased (~5-fold) retinal apoptosis compared to wild-type

endocrine/exocrine glands
• mice have a profoundly hypocellular thymus with 50- 170-fold fewer cells than controls




Genotype
MGI:3655990
hm2
Allelic
Composition
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• a small number of Lig4+/+, Xrcc5tm1Dbr null animals (4/131) have reached maturity and are viable; this is equivalent to observed viability of Xrcc5-null animals
• some Lig4 +/+/Xrcc5-null animals have been live born compared to total lethality of Lig4 single null animals

cellular
• numbers of cultured cells show a higher percentage of chromosome aberrations than wild-type cells (~60% vs ~10%)




Genotype
MGI:5013937
hm3
Allelic
Composition
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the spinal cord at E12.5

cellular
• in the spinal cord at E12.5




Genotype
MGI:3655989
ht4
Allelic
Composition
Xrcc5tm1Dbr/Xrcc5+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• ~20% of heterozygous cells in culture exhibit chromosomal instability




Genotype
MGI:3655987
cx5
Allelic
Composition
Xrcc5tm1Dbr/Xrcc5+
Lig4tm1Fwa/Lig4+
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Fwa mutation (1 available); any Lig4 mutation (44 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cultured fibroblasts display chromosomal instability at a level of ~32%, similar to heterozygous Lig4 fibroblasts




Genotype
MGI:3655986
cx6
Allelic
Composition
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Lig4tm1Fwa/Lig4tm1Fwa
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Fwa mutation (1 available); any Lig4 mutation (44 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• a small number of tm1Fwa, Xrcc5tm1Dbr null animals (4/131) have reached maturity and are viable; this is equivalent to observed viability of Xrcc5-null animals
• 4/131 Lig4/Xrcc5 double null animals have been live born compared to total lethality of Lig4 single null animals

immune system
• double mutants show lymphoid depletion similar to that observed in Xrcc5-deficient mice

hematopoietic system
• double mutants show lymphoid depletion similar to that observed in Xrcc5-deficient mice

digestive/alimentary system
• small intestines show smaller villi relative to wild-type and Xrcc5-deficient mice

cellular
• numbers of cultured cells show similar total percentage of chromosome aberrations to Xrcc4-deficient cells (~60% vs ~10% of wild-type cells)




Genotype
MGI:3818750
cx7
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit a focal increase in external granule cells compared to in wild-type mice

neoplasm
N
• despite the increase in granule cells, mice do not develop medulloblastoma




Genotype
MGI:3818751
cx8
Allelic
Composition
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median lifespan is 7 weeks
• maximum lifespan is 16 weeks

neoplasm
• in 8 of 13 mice

nervous system




Genotype
MGI:3818748
cx9
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Trp53tm1Brd/Trp53tm1Brd
Xrcc5tm1Dbr/Xrcc5tm1Dbr
Genetic
Background
involves: 129S7/SvEvBrd * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
Xrcc5tm1Dbr mutation (0 available); any Xrcc5 mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median lifespan is 14 weeks compared to 7 weeks in Trp53tm1Brd Xrcc5tm1Dbr
• maximum lifespan is 20 weeks compared to 16 weeks in Trp53tm1Brd Xrcc5tm1Dbr

neoplasm
• one mouse developed a stomach neoplasm
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

respiratory system
• one-fifth of mice exhibit labored breathing prior to death compared to two-thirds of Rag1tm1Mom Trp53tm1Brd

behavior/neurological
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

homeostasis/metabolism
• two-thirds of mice exhibit an acute onset of vertigo that leads to disabled mobility and severe dehydration as a result of inability to reach the water source

endocrine/exocrine glands
• 55% mice develop T cell lymphomas in the liver, spleen, lymph nodes, bone marrow, kidney, heart, lungs and ovaries

nervous system
• mice that exhibit vertigo develop medulloblastoma
• 66.7% of mice exhibit medulloblastoma at the time of morbidity

digestive/alimentary system
• one mouse developed a stomach neoplasm

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:141515





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory