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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
F8tm2Kaz
targeted mutation 2, Haig H Kazazian Jr
MGI:2179968
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
F8tm2Kaz/Y
Tg(Alb-F8)EBmre/0
involves: 129S4/SvJae * C57BL/6J MGI:5297961
ot2
F8tm2Kaz/Y involves: 129S4/SvJae MGI:5297962
ot3
F8tm2Kaz/Y involves: 129S4/SvJae * C57BL/6 MGI:2449546


Genotype
MGI:5297961
cx1
Allelic
Composition
F8tm2Kaz/Y
Tg(Alb-F8)EBmre/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm2Kaz mutation (0 available); any F8 mutation (12 available)
Tg(Alb-F8)EBmre mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after tail cut, blood loss is greater than in wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemophilia A; HEMA 306700 J:176909




Genotype
MGI:5297962
ot2
Allelic
Composition
F8tm2Kaz/Y
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm2Kaz mutation (0 available); any F8 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• after tail cut, blood loss is greater than in wild-type mice




Genotype
MGI:2449546
ot3
Allelic
Composition
F8tm2Kaz/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F8tm2Kaz mutation (0 available); any F8 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• males exhibit hemophilia (J:24941)
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized; however, no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)
• plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)
• females exhibit normal fertility and pregnancy (J:36698)
• males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemophilia A; HEMA 306700 J:24941





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory