Analysis Tools
behavior/neurological
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• ESP1(Gm6084)-stimulated female mice fail to exhibit an increase in lordosis behavior and successful intromission by males unlike similarly treated wild-type mice
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Allele Symbol Allele Name Allele ID |
Trpc2tm1Rax targeted mutation 1, Richard Axel MGI:2179812 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• ESP1(Gm6084)-stimulated female mice fail to exhibit an increase in lordosis behavior and successful intromission by males unlike similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• naive male homozygotes rarely initiate biting attacks in a resident-intruder assay, with only 4.3% displaying aggressive attack behavior towards a male intruder vs 64% of controls; all measures of aggressive behavior (latency to attack, attack frequency and attack duration) are significantly diminished
• absence of intermale aggression cannot be enhanced by prior mating or fighting experience
• furthermore, all lactating female homozygotes fail to initiate attacks toward intruder males in a maternal aggression assay
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• although both mutant and control males mark in a dominant fashion before a fighting experience, male homozygotes become subordinated and suppress territorial marking after repetitive pairing with controls; in 91% of cases the control is dominant over the mutant, as assessed by marking
• after repetitive pairing, analysis of territorial marking patterns of mutant pairs indicates that male homozygotes do not form normal dominant-subordinate relationships
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• both naive and sexually inexperienced male homozygotes display normal sexual behavior toward estrous females; however, upon exposure to wild-type intruder males for 15 min, sexually inexperienced, singly housed males show a 6-fold increase in the number of intermale mounts relative to control mice
• sexually experienced male homozygotes show a 16-fold increase in the frequency of male-male mounting relative to control males
• male homozygotes show a significantly higher number of intermale mounts than controls both before and after mating experience with females
• in fact, male homozygotes continue to mount males at a high rate even when a female is present in the home cage
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• homozygotes display a striking reduction in the electrophysiological responses of vomeronasal sensory neurons to synthetic and natural pheromones relative to wild-type and heterozygous control mice
• unlike control mice, homozygotes fail to respond to 2-heptanone at 10-7 M, and exhibit only a small response to 2-heptanone at 10-4 M; on average, the size of the electro-vomeronasogram (EVG) response to 2-heptanone at 10-4 M is reduced to ~25% of control mice
• unlike control mice, homozygotes fail to elicit a urine-evoked field potential at dilutions of urine of 1/105, while peak EVG responses to female or male urine, at dilutions of 1/102, are reduced to ~37% of wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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