All Phenotypes Syp<tm1Sud> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Syp^tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179741

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syp^tm1Sud/Syp^tm1Sud	involves: 129S1/Sv * 129X1/SvJ	MGI:2179742
cx2	Syngr1^tm1Sud/Syngr1^tm1Sud Syp^tm1Sud/Syp^tm1Sud	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:2180497
cx3	Syngr1^tm1Sud/Syngr1^tm1Sud Syngr3^tm1Sud/Syngr3^tm1Sud Synpr^tm1Sud/Synpr^tm1Sud Syp^tm1Sud/Syp^tm1Sud	Not Specified	MGI:4421434

Allelic Composition	Syp^tm1Sud/Syp^tm1Sud
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syp^tm1Sud mutation (1 available); any Syp mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:33035 )

• homozygous mice exhibit no detectable abnormalities in central nervous system morphology or physiology

Allelic Composition	Syngr1^tm1Sud/Syngr1^tm1Sud Syp^tm1Sud/Syp^tm1Sud
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngr1^tm1Sud mutation (1 available); any Syngr1 mutation (39 available)
Syp^tm1Sud mutation (1 available); any Syp mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

impaired synaptic plasticity ( J:58559 )

reduced long-term potentiation ( J:58559 )

• reduced LTP was noted upon tetanic field stimulation

decreased post-tetanic potentiation ( J:58559 )

• amplitude was reduced by 50% compared to controls

decreased paired-pulse facilitation ( J:58559 )

• an impairment was noted at all interpulse intervals examined

Allelic Composition	Syngr1^tm1Sud/Syngr1^tm1Sud Syngr3^tm1Sud/Syngr3^tm1Sud Synpr^tm1Sud/Synpr^tm1Sud Syp^tm1Sud/Syp^tm1Sud
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngr1^tm1Sud mutation (1 available); any Syngr1 mutation (39 available)
Syngr3^tm1Sud mutation (1 available); any Syngr3 mutation (17 available)
Synpr^tm1Sud mutation (1 available); any Synpr mutation (12 available)
Syp^tm1Sud mutation (1 available); any Syp mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

seizures ( J:156812 )

• seizures may occur after about 2 months of age, triggered by lifting mice up by the tail (highest incidence) or other sensory stimuli (less common)

nervous system

seizures ( J:156812 )

• seizures may occur after about 2 months of age, triggered by lifting mice up by the tail (highest incidence) or other sensory stimuli (less common)

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