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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syptm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:2179741
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Syptm1Sud/Syptm1Sud involves: 129S1/Sv * 129X1/SvJ MGI:2179742
cx2
Syngr1tm1Sud/Syngr1tm1Sud
Syptm1Sud/Syptm1Sud
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:2180497
cx3
Syngr1tm1Sud/Syngr1tm1Sud
Syngr3tm1Sud/Syngr3tm1Sud
Synprtm1Sud/Synprtm1Sud
Syptm1Sud/Syptm1Sud
Not Specified MGI:4421434


Genotype
MGI:2179742
hm1
Allelic
Composition
Syptm1Sud/Syptm1Sud
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syptm1Sud mutation (1 available); any Syp mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygous mice exhibit no detectable abnormalities in central nervous system morphology or physiology




Genotype
MGI:2180497
cx2
Allelic
Composition
Syngr1tm1Sud/Syngr1tm1Sud
Syptm1Sud/Syptm1Sud
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngr1tm1Sud mutation (1 available); any Syngr1 mutation (34 available)
Syptm1Sud mutation (1 available); any Syp mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduced LTP was noted upon tetanic field stimulation
• amplitude was reduced by 50% compared to controls
• an impairment was noted at all interpulse intervals examined




Genotype
MGI:4421434
cx3
Allelic
Composition
Syngr1tm1Sud/Syngr1tm1Sud
Syngr3tm1Sud/Syngr3tm1Sud
Synprtm1Sud/Synprtm1Sud
Syptm1Sud/Syptm1Sud
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syngr1tm1Sud mutation (1 available); any Syngr1 mutation (34 available)
Syngr3tm1Sud mutation (1 available); any Syngr3 mutation (16 available)
Synprtm1Sud mutation (1 available); any Synpr mutation (10 available)
Syptm1Sud mutation (1 available); any Syp mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seizures may occur after about 2 months of age, triggered by lifting mice up by the tail (highest incidence) or other sensory stimuli (less common)

nervous system
• seizures may occur after about 2 months of age, triggered by lifting mice up by the tail (highest incidence) or other sensory stimuli (less common)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory