Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1(EGFP)Irw mutation
(1 available);
any
Ccr6 mutation
(36 available)
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immune system
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• splenocytes from mice infected with Y. enterocolitica produce much less IFN-gamma than controls
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• splenocytes from mice infected with Y. enterocolitica produce much less IL-12 than controls
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• splenocytes from mice infected with Y. enterocolitica produce much less IL-4 than controls
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• splenocytes from mice infected with Y. enterocolitica produce much less TFN than controls
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• mice are resistant to oral Y. enterocolitica infection
• six days after infection wild-type mice appear humpbacked and shaggy with large Peyer's patches and lesions present in the intestines, liver and spleen
• mutant mice do not display these infectious symptoms even with 20-fold higher oral doses
• splenocytes from infected mice make much less IL-4, IL-12, TNF, and IFN-gamma than wild-type controls
• mutant mice do become sick after i.p. infection with Y. enterocolitica
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1(EGFP)Irw mutation
(1 available);
any
Ccr6 mutation
(36 available)
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immune system
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• Peyer's patches have fewer domes (mean of 1.5 vs. 3.5 in controls) with less total surface area
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• small intestine alpha-beta intraepithelial lymphocyte (IEL) numbers are increased 2.7 fold
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• CD4+ CD8alpha-alpha IEL numbers are increased 6.3-fold
• CD4+ IEL numbers are increased 2.1 fold
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• CD4- CD8alpha-alpha IEL numbers are increased 3.2-fold
• CD4+ CD8alpha-alpha IEL numbers are increased 6.3-fold
• CD8alphabeta IEL numbers are increased 2-fold
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• bone marrow chimera experiments demonstrate that mutant B cells lack the ability to develop isolated lymphoid follicles from cryptopatches
• when B cells are injected into B-cell deficient hosts ( Igh-Jtm1Cgn homozygotes), mutant B cells are 3-fold less efficient in migrating to Peyer's patches and 2-fold less efficient in migration to cryptopatches compared to controls
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• IEL lytic activity is increased
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• proliferation rate of alpha-beta IEL is higher by almost 2-fold compared to controls
• alphabeta T cell proliferation was also increased
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• after S. typhimurium infection of the gut, dendritic cells fail to migrate to the follicular associated epithelium in the small intestine
(J:113363)
• there is a near absence of immature and mature isolated lymphoid follicles (ILF) found in the small intestine
(J:120122)
• augmenting ILF development by LTbetaR-Ig treatment only modestly increases mature ILF numbers compared to the 8-fold increase seen in controls
(J:120122)
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• Peyer's patches have fewer domes (mean of 1.5 vs. 3.5 in controls) with less total surface area
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• totally cellularity of the Peyer's Patch is less than half of controls
• less B cells are found in the Peyer's patches of the small intestine
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• after S. typhimurium infection of the gut, dendritic cells fail to migrate to the follicular associated epithelium in the small intestine
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hematopoietic system
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• Peyer's patches have fewer domes (mean of 1.5 vs. 3.5 in controls) with less total surface area
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• small intestine alpha-beta intraepithelial lymphocyte (IEL) numbers are increased 2.7 fold
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• CD4+ CD8alpha-alpha IEL numbers are increased 6.3-fold
• CD4+ IEL numbers are increased 2.1 fold
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• CD4- CD8alpha-alpha IEL numbers are increased 3.2-fold
• CD4+ CD8alpha-alpha IEL numbers are increased 6.3-fold
• CD8alphabeta IEL numbers are increased 2-fold
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• bone marrow chimera experiments demonstrate that mutant B cells lack the ability to develop isolated lymphoid follicles from cryptopatches
• when B cells are injected into B-cell deficient hosts ( Igh-Jtm1Cgn homozygotes), mutant B cells are 3-fold less efficient in migrating to Peyer's patches and 2-fold less efficient in migration to cryptopatches compared to controls
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• IEL lytic activity is increased
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• proliferation rate of alpha-beta IEL is higher by almost 2-fold compared to controls
• alphabeta T cell proliferation was also increased
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cellular
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• proliferation rate of alpha-beta IEL is higher by almost 2-fold compared to controls
• alphabeta T cell proliferation was also increased
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