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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Skp2tm1Kin
targeted mutation 1, Kei-ichi Nakayama
MGI:2179051
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Skp2tm1Kin/Skp2tm1Kin involves: 129P2/OlaHsd MGI:4941321
hm2
Skp2tm1Kin/Skp2tm1Kin involves: 129P2/OlaHsd * C57BL/6 MGI:3036548
cx3
Cdkn1btm1Kin/Cdkn1btm1Kin
Skp2tm1Kin/Skp2tm1Kin
involves: 129P2/OlaHsd * C57BL/6 MGI:3036549


Genotype
MGI:4941321
hm1
Allelic
Composition
Skp2tm1Kin/Skp2tm1Kin
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp2tm1Kin mutation (1 available); any Skp2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocytes exhibit aberrant V(D)J recombination compared with wild-type cells

immune system
• thymocytes exhibit aberrant V(D)J recombination compared with wild-type cells




Genotype
MGI:3036548
hm2
Allelic
Composition
Skp2tm1Kin/Skp2tm1Kin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Skp2tm1Kin mutation (1 available); any Skp2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• rate of apoptosis among embryo fibroblasts is almost doubled
• growth rate of MEF and T cells in culture is slow
• abnormal amplification of centrosomes in about 38% of cells in culture

endocrine/exocrine glands
• large cells in testes
• cells with enlarged nuclei

growth/size/body
• body weights are about 2/3 wild-type controls
• external body proportions were normal however

liver/biliary system
• large hepatocytes (J:62130)
• enlarged nuclei in hepatocytes (J:62130)
• after recovery from partial hepatectomy cell and nuclear enlargement of hepatocytes is particularly marked (J:75027)
• DNA content of cells is greatly increased (J:75027)

renal/urinary system
• large kidney cells
• cells with enlarged nuclei

reproductive system
• large cells in testes
• cells with enlarged nuclei

homeostasis/metabolism
• cell proliferation in wound recovery is slower than normal




Genotype
MGI:3036549
cx3
Allelic
Composition
Cdkn1btm1Kin/Cdkn1btm1Kin
Skp2tm1Kin/Skp2tm1Kin
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1btm1Kin mutation (1 available); any Cdkn1b mutation (25 available)
Skp2tm1Kin mutation (1 available); any Skp2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• cell proliferation in wound recovery is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory