cellular
|
• rate of apoptosis among embryo fibroblasts is almost doubled
|
|
• growth rate of MEF and T cells in culture is slow
• abnormal amplification of centrosomes in about 38% of cells in culture
|
endocrine/exocrine glands
|
• large cells in testes
• cells with enlarged nuclei
|
growth/size/body
|
• body weights are about 2/3 wild-type controls
• external body proportions were normal however
|
liver/biliary system
|
• large hepatocytes
(J:62130)
• enlarged nuclei in hepatocytes
(J:62130)
• after recovery from partial hepatectomy cell and nuclear enlargement of hepatocytes is particularly marked
(J:75027)
• DNA content of cells is greatly increased
(J:75027)
|
renal/urinary system
|
• large kidney cells
• cells with enlarged nuclei
|
reproductive system
|
• large cells in testes
• cells with enlarged nuclei
|
homeostasis/metabolism