Phenotypes associated with this allele

• Allele Symbol: Sycp3^tm1Hoog
• Allele Name: targeted mutation 1, Christer Hoog
• Allele ID: MGI:2179041
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sycp3^tm1Hoog/Sycp3^tm1Hoog	involves: 129P2/OlaHsd * C57BL/6	MGI:2664131
hm2	Sycp3^tm1Hoog/Sycp3^tm1Hoog	involves: 129P2/OlaHsd * C57BL/6NCrl	MGI:2664140

Genotype
MGI:2664131

hm1

• Allelic Composition: Sycp3^tm1Hoog/Sycp3^tm1Hoog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:60153 )

♂ • spermatozoa absent from caudal epididymis

abnormal spermatocyte morphology ( J:60153 )

♂ • apoptosis of meiotic spermatocytes

small seminiferous tubules ( J:60153 )

♂ • 40% reduction in diameter

decreased testis weight ( J:60153 )

♂ • 70% reduction in weight relative to wild-type

arrest of male meiosis ( J:60153 )

♂ • arrest at zygotene stage of prophase I

♂ • impaired chromosomal synapsis

male infertility ( J:60153 )

♂

endocrine/exocrine glands

small seminiferous tubules ( J:60153 )

♂ • 40% reduction in diameter

decreased testis weight ( J:60153 )

♂ • 70% reduction in weight relative to wild-type

cellular

azoospermia ( J:60153 )

♂ • spermatozoa absent from caudal epididymis

abnormal spermatocyte morphology ( J:60153 )

♂ • apoptosis of meiotic spermatocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
azoospermia		DOID:14227		J:60153

Genotype
MGI:2664140

hm2

• Allelic Composition: Sycp3^tm1Hoog/Sycp3^tm1Hoog
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrl

reproductive system

abnormal female meiosis ( J:76511 )

♀ • defective chromosomal segregation leading to aneuploidy

reduced female fertility ( J:76511 )

♀ • decreased fertility with age

decreased litter size ( J:76511 )

• embryonic loss due to aneuploidy