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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adarb1tm1Phs
targeted mutation 1, Peter H Seeburg
MGI:2178079
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adarb1tm1Phs/Adarb1tm1Phs involves: 129S1/Sv * 129X1/SvJ MGI:2654778
cx2
Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2tm1.1Phs
involves: 129S1/Sv * 129X1/SvJ MGI:3045882
cx3
Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2+
involves: 129S1/Sv * 129X1/SvJ MGI:3045883


Genotype
MGI:2654778
hm1
Allelic
Composition
Adarb1tm1Phs/Adarb1tm1Phs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (1 available); any Adarb1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous null mice die young between P0 and P20
• Q/R site editing in primary Gria2 transcripts is 10-fold lower in homozygous null mice relative to wild-type; authors identified the Q/R site codon in Gria2 pre-mRNA as a crucial physiological substrate of ADARB1, perhaps the only one at which editing is required for postnatal viability

behavior/neurological
• homozygotes display a progressive susceptibility to seizures after P12

nervous system
• homozygotes display a progressive susceptibility to seizures after P12
• AMPA receptor-mediated currents in brain slices from nucleated patches of CA1 pyramidal cells and other principal neurons show pronounced rectification, increased desensitization rates and a 30-fold higher Ca2+ permeability
• the macroscopic AMPA receptor-mediated conductance in CA1 pyramidal cells is significantly higher than in mouse mutants expressing editing-deficient Gria2 genes, and appears to be the primary cause for the high seizure susceptibility of young mice expressing Q/R site-unedited Gria2 transcripts




Genotype
MGI:3045882
cx2
Allelic
Composition
Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2tm1.1Phs
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (1 available); any Adarb1 mutation (8 available)
Gria2tm1.1Phs mutation (1 available); any Gria2 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• double homozygous null mice appear normal at all ages, as judged by food intake, weight increase, postnatal development, breeding and general behavior (full rescue)




Genotype
MGI:3045883
cx3
Allelic
Composition
Adarb1tm1Phs/Adarb1tm1Phs
Gria2tm1.1Phs/Gria2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adarb1tm1Phs mutation (1 available); any Adarb1 mutation (8 available)
Gria2tm1.1Phs mutation (1 available); any Gria2 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• compound mutant mice survive up to P35 (partial rescue; extended postnatal survival)





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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory