All Phenotypes Hoxd12<tm2Ddu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxd12^tm2Ddu
targeted mutation 2, Denis Duboule
MGI:2177960

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd12^tm2Ddu/Hoxd12^tm2Ddu	involves: 129S2/SvPas	MGI:2178062
cx2	Hoxd12^tm2Ddu/Hoxd12⁺ Hoxd13^tm1Ddu/Hoxd13⁺	either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)	MGI:2178077
cx3	Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu Hoxd12^tm2Ddu/Hoxd12^tm2Ddu	involves: 129S2/SvPas	MGI:2178067
cx4	Hoxd12^tm2Ddu/Hoxd12^tm2Ddu Hoxd13^tm2Ddu/Hoxd13^tm2Ddu	involves: 129S2/SvPas	MGI:3840844

Allelic Composition	Hoxd12^tm2Ddu/Hoxd12^tm2Ddu
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12^tm2Ddu mutation (1 available); any Hoxd12 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal internal anal sphincter morphology ( J:36770 )

• ill-formed internal anal sphincter

muscle

abnormal smooth muscle morphology ( J:36770 )

• marked disorganization of rectal muscle layers in the region of the internal anal sphincter, with an abnormally thin or degenerated outer muscle layer

abnormal internal anal sphincter morphology ( J:36770 )

• ill-formed internal anal sphincter

limbs/digits/tail

abnormal phalanx morphology ( J:36770 )

• minor reduction of the second phalange of digit V

brachydactyly ( J:47366 )

• some digital elements are slightly reduced compared to in wild-type mice

skeleton

abnormal phalanx morphology ( J:36770 )

• minor reduction of the second phalange of digit V

Allelic Composition	Hoxd12^tm2Ddu/Hoxd12⁺ Hoxd13^tm1Ddu/Hoxd13⁺
Genetic Background	either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12^tm2Ddu mutation (1 available); any Hoxd12 mutation (13 available)
Hoxd13^tm1Ddu mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:36770 )

• postminimus in 80% of trans-heterozygous mice

brachyphalangia ( J:36770 )

• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges

brachydactyly ( J:36770 )

• trans-heterozygous mice exhibit a reduction of digits V and II in the forelimbs

skeleton

brachyphalangia ( J:36770 )

• reduction in digit size of trans-heterozygous mice is most prominent in the second phalanges

Allelic Composition	Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu Hoxd12^tm2Ddu/Hoxd12^tm2Ddu
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Hoxd12^tm2Ddu mutation (1 available); any Hoxd12 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal phalanx morphology ( J:47900 )

• reduction in size of second phalange of digit II

• absent second phalange of digit V

skeleton

abnormal phalanx morphology ( J:47900 )

• absent second phalange of digit V

• reduction in size of second phalange of digit II

Allelic Composition	Hoxd12^tm2Ddu/Hoxd12^tm2Ddu Hoxd13^tm2Ddu/Hoxd13^tm2Ddu
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd12^tm2Ddu mutation (1 available); any Hoxd12 mutation (13 available)
Hoxd13^tm2Ddu mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced male fertility ( J:47366 )

limbs/digits/tail

abnormal carpal bone morphology ( J:47366 )

• d5 and d5* split from d4 and supernumerary distal carpal-like ossifications are found in the interdigital region unlike in wild-type mice

abnormal digit morphology ( J:47366 )

• digits are more severely affected than in Hoxd13^tm1Ddu

• malformed articulations in forelimb digits II, III, and IV form a single metacarpophalangeal rod unlike in wild-type mice

polydactyly ( J:47366 )

• in 20% of mice a broader than normal digit V splits to form a full postaxial extra digit

abnormal metatarsal bone morphology ( J:47366 )

• metatarsals V and I are broader than normal

skeleton

abnormal carpal bone morphology ( J:47366 )

• d5 and d5* split from d4 and supernumerary distal carpal-like ossifications are found in the interdigital region unlike in wild-type mice

abnormal metatarsal bone morphology ( J:47366 )

• metatarsals V and I are broader than normal

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