Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pin1tm1Tuc mutation
(2 available);
any
Pin1 mutation
(17 available)
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endocrine/exocrine glands
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• ovaries contained fewer follicles
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reproductive system
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• reduced number of primordial germ cells (PGCs) at 13.5 dpc
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• decreased proliferation of PGCs due to a prolonged cell cycle
• no ectopic PGC migration, cell cycle arrest, or apoptosis observed
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• ovaries contained fewer follicles
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cellular
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• reduced number of primordial germ cells (PGCs) at 13.5 dpc
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• decreased proliferation of PGCs due to a prolonged cell cycle
• no ectopic PGC migration, cell cycle arrest, or apoptosis observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pin1tm1Tuc mutation
(2 available);
any
Pin1 mutation
(17 available)
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nervous system
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• levels of insoluble amyloid beta42 are increased by 32% in the brains of mutants at 15 months of age compared to wild-type mice
• however, no changes in the levels of amyloid beta40 or amyloid beta42 is seen at 2-6 months of age
• these results indicate an age-dependent and selective increase in insoluble amyloid beta42 as observed in Alzheimer's patients
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pin1tm1Tuc mutation
(2 available);
any
Pin1 mutation
(17 available)
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Reduced body weight and testicular atrophy in Pin1tm1Tuc/Pin1tm1Tuc mice
endocrine/exocrine glands
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• failure to undergo lobuloalveolar development during pregnancy due to impaired development and proliferation of mammary epithelia cells
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• evident around 3.5 months of age
• more pronounced at 18 months of age, at which point mature sperm was undetected
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• 44% reduction in testicular weight relative to wild-type by 3 to 5 months of age
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growth/size/body
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• body weight was similar to that of wild-type until 3 months of age
• 29% reduction in body weight at 7 months of age relative to wild-type
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reproductive system
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• mature spermatocytes undetected in the seminiferous tubules at 18 months of age
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• failure to undergo lobuloalveolar development during pregnancy due to impaired development and proliferation of mammary epithelia cells
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• evident around 3.5 months of age
• more pronounced at 18 months of age, at which point mature sperm was undetected
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• 44% reduction in testicular weight relative to wild-type by 3 to 5 months of age
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vision/eye
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• approximately 50% of mice exhibited retinal degeneration at 4 to 6 months of age, with progression and increased penetrance at 16 months of age
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integument
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• failure to undergo lobuloalveolar development during pregnancy due to impaired development and proliferation of mammary epithelia cells
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cellular
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• mature spermatocytes undetected in the seminiferous tubules at 18 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pin1tm1Tuc mutation
(2 available);
any
Pin1 mutation
(17 available)
Tg(APPSWE)2576Kha mutation
(5 available)
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nervous system
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• levels of insoluble amyloid beta, especially amyloid beta42, are increased by 46% at 6 months of age compared to single Tg(APPSWE)2576Kha hemizygous controls
• however, levels of soluble amyloid beta40 and amyloid beta42 are not affected
• amyloid beta42 predominately accumulates in multivesicular bodies of neurons
• levels of total APPs and beta-APPs are increased by about 3-fold, but levels of alpha-APPs are reduced by about 50% compared to single Tg(APPSWE)2576Kha hemizygous controls, indicating an increase in amyloidogenic versus non-amyloidogenic APP processing and thus elevation of the amyloid beta42
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homeostasis/metabolism
Analysis Tools