Mouse Genome Informatics
hm1
     Capn3tm1Jsb/Capn3tm1Jsb
either: 129/Sv-Capn3tm1Jsb or (involves: 129/Sv * C57BL/6)
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype

Dystrophic muscle in Capn3tm1Jsb/Capn3tm1Jsb mice

muscle
abnormal sarcolemma morphology ( J:66862 )
• disruption of sarcolemmal integrity
dystrophic muscle ( J:66862 )
• mutants develop a progressive mild muscular dystrophy
• most severly affects the psoas, soleus, and deltoid muscles
• Background Sensitivity: dystrophic muscle is evident at 2 months of a age in mutants on a 129/Sv background while it becomes evident in mutants on a mixed 129/Sv and C57BL/6 at 6 months of age
• myofibers exhibit an increase in apoptosis

reproductive system
transmission ratio distortion ( J:66862 )
• transmission ratio distortion, preferred transmission of mutant allele

Mouse Models of Human Disease
 OMIM IDRef(s)
Muscular Dystrophy, Limb-Girdle, Type 2A; LGMD2A 253600 J:66862


Mouse Genome Informatics
cx2
     Capn3tm1Jsb/Capn3+
Ttntm1.1Isrd/Ttn+
involves: 129/Sv * 129S2/SvPas * C57BL/6
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
normal phenotype

Mouse Models of Human Disease
 OMIM IDRef(s)
NOT Tibial Muscular Dystrophy, Tardive 600334 J:165576


Mouse Genome Informatics
cx3
     Capn3tm1Jsb/Capn3+
Ttntm1.1Isrd/Ttntm1.1Isrd
involves: 129/Sv * 129S2/SvPas * C57BL/6
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
muscle
dystrophic muscle ( J:165576 )
• especially in soleus and the tibialis anterior

cardiovascular system