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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mapk14tm1Mms
targeted mutation 1, Michael M Shen
MGI:2177832
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mapk14tm1Mms/Mapk14tm1Mms involves: 129S7/SvEvBrd * C57BL/6 MGI:3513555


Genotype
MGI:3513555
hm1
Allelic
Composition
Mapk14tm1Mms/Mapk14tm1Mms
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1Mms mutation (0 available); any Mapk14 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphology and histology of wild type and Mapk14tm1Mms/Mapk14tm1Mms mouse embryos and placentas

mortality/aging
• homozygotes die in utero between 10.5 and 12.5 dpc

cardiovascular system
• at 10.5 dpc, the angiogenic mesenchyme fails to infiltrate the developing labyrinth layer
• by 11.5 dpc, homozygotes exhibit a severely impaired vascular network within the labyrinth, with a nearly complete loss of blood vessels lined with endothelial cells
• at 10.5 dpc, homozygotes display an angiogenic defect in embryonic and extraembryonic tissues that correlates with impaired placental vascularization
• at 10.5 dpc, mutant brains fail to show angiogenic pruning and remodeling of the vascular plexus, displaying numerous vessels of similar size that are not organized in a branching vascular tree

cellular
• mutant ES cells show no overt growth or differentiation phenotypes in early embryoid body culture
• notably, attempts to culture primary MEFs are unsuccessful due to cellular inviability following the first passage

embryo
• by 11.5 dpc, mutant embryos are often developmentally retarded and smaller than wild-type embryos
• at 10.5 dpc, the mutant placenta appears thinner and paler than normal; however, the chorioallantoic fusion appears unaffected
• at 10.5 dpc, the angiogenic mesenchyme fails to infiltrate the developing labyrinth layer
• by 11.5 dpc, homozygotes exhibit a severely impaired vascular network within the labyrinth, with a nearly complete loss of blood vessels lined with endothelial cells
• at 10.5 dpc, homozygotes exhibit a highly abnormal diploid trophoblast with abundant apoptotic cells in the placental labyrinth layer; no differences are noted in the trophoblast giant cell population
• at 10.5 dpc, the mutant spongiotrophoblast layer is significantly reduced
• at 10.5 dpc, the developing labyrinth of homozygotes is significantly thinner than that of wild-type embryos
• by 11.5 dpc, the mutant labyrinth layer is essentially absent
• at 10.5 dpc, mutant visceral yolk sacs lack major blood vessels and retain a primitive capillary plexus

growth/size/body
• by 11.5 dpc, mutant embryos are often developmentally retarded and smaller than wild-type embryos

hematopoietic system
N
• mutant embryos display no gross abnormalities in primitive hematopoiesis or cardiac development





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory