Phenotypes associated with this allele

• Allele Symbol: Htt^tm2.1Pfs
• Allele Name: targeted mutation 2.1, Peggy F Shelbourne
• Allele ID: MGI:2177753
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Htt^tm2.1Pfs/Htt^+	involves: 129X1/SvJ * C57BL/6	MGI:3698754

Genotype
MGI:3698754

ht1

• Allelic Composition: Htt^tm2.1Pfs/Htt⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased aggression towards mice ( J:54906 )

• exhibit heightened aggression amongst group housed males and females and increased incidence of isolation-induced aggression in the resident-intruder test

nervous system

decreased brain size ( J:54906 )

• brains are, on average, 10-15% smaller at 4-6 months of age

• however, do not exhibit any pathological gliosis, ventricular enlargement, or neurodegeneration at 4-6 and 16-17 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:54906