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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gcktm1.1Mgn
targeted mutation 1.1, Mark A Magnuson
MGI:2177709
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gcktm1.1Mgn/Gcktm1.1Mgn 129S6/SvEvTac-Gcktm1.1Mgn MGI:3590683
hm2
Gcktm1.1Mgn/Gcktm1.1Mgn involves: 129S6/SvEvTac * C57BL/6 MGI:3590680
cn3
Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3603003
cn4
Gcktm1.1Mgn/Gck+
Tg(Ins2-cre)25Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3603012
cn5
Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Alb-cre)21Mgn/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3603013


Genotype
MGI:3590683
hm1
Allelic
Composition
Gcktm1.1Mgn/Gcktm1.1Mgn
Genetic
Background
129S6/SvEvTac-Gcktm1.1Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• slight increase in blood glucose concentration (165 mg/dl vs. 132 mg/dl in wild-type)




Genotype
MGI:3590680
hm2
Allelic
Composition
Gcktm1.1Mgn/Gcktm1.1Mgn
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• about 10% increase in blood glucose concentration (194 mg/dl vs. 175 mg/dl in wild-type)




Genotype
MGI:3603003
cn3
Allelic
Composition
Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (35 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than 80% neonatal mortality as a result of severe hyperglycemia

homeostasis/metabolism
• highly variable but increased blood glucose concentrations
• decreased by about 70%
• diminished hepatic glycogen

liver/biliary system

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826




Genotype
MGI:3603012
cn4
Allelic
Composition
Gcktm1.1Mgn/Gck+
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (35 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 70% decrease in insulin secretion during hyperglycemic clamp studies
• blood glucose concentration is increased by about 50% compared to heterozygous Gcktm1.1Mgn mice
• under fasting conditions, have a 25% increase in blood glucose concentration, without differences in basal insulin concentration
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced by about 60 and 70%, respectively
• net glycogen synthesis in liver is reduced by about 50% during hyperglycemic clamp studies

endocrine/exocrine glands
• 70% decrease in insulin secretion during hyperglycemic clamp studies

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826




Genotype
MGI:3603013
cn5
Allelic
Composition
Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Alb-cre)21Mgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gcktm1.1Mgn mutation (1 available); any Gck mutation (35 available)
Tg(Alb-cre)21Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• secrete 70% less insulin in response to glucose stimulus
• 10% increase in fed blood glucose concentration
• post-absorptive (fed) plasma insulin concentrations twice that of controls
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced
• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies
• mild insulin resistance

endocrine/exocrine glands
• secrete 70% less insulin in response to glucose stimulus

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory