• slight increase in blood glucose concentration (165 mg/dl vs. 132 mg/dl in wild-type)

• about 10% increase in blood glucose concentration (194 mg/dl vs. 175 mg/dl in wild-type)

• more than 80% neonatal mortality as a result of severe hyperglycemia

• highly variable but increased blood glucose concentrations

• decreased by about 70%

• diminished hepatic glycogen

• 70% decrease in insulin secretion during hyperglycemic clamp studies

• blood glucose concentration is increased by about 50% compared to heterozygous Gck^tm1.1Mgn mice

• under fasting conditions, have a 25% increase in blood glucose concentration, without differences in basal insulin concentration

• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced by about 60 and 70%, respectively

• net glycogen synthesis in liver is reduced by about 50% during hyperglycemic clamp studies

• 70% decrease in insulin secretion during hyperglycemic clamp studies

• secrete 70% less insulin in response to glucose stimulus

• 10% increase in fed blood glucose concentration

• post-absorptive (fed) plasma insulin concentrations twice that of controls

• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced

• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies

• mild insulin resistance

• secrete 70% less insulin in response to glucose stimulus