Mouse Genome Informatics
hm1
    Gcktm1.1Mgn/Gcktm1.1Mgn
129S6/SvEvTac-Gcktm1.1Mgn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• slight increase in blood glucose concentration (165 mg/dl vs. 132 mg/dl in wild-type)


Mouse Genome Informatics
hm2
    Gcktm1.1Mgn/Gcktm1.1Mgn
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• about 10% increase in blood glucose concentration (194 mg/dl vs. 175 mg/dl in wild-type)


Mouse Genome Informatics
cn3
    Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Ins2-cre)25Mgn/0

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• more than 80% neonatal mortality as a result of severe hyperglycemia

homeostasis/metabolism
• highly variable but increased blood glucose concentrations
• decreased by about 70%
• diminished hepatic glycogen

liver/biliary system

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826


Mouse Genome Informatics
cn4
    Gcktm1.1Mgn/Gck+
Tg(Ins2-cre)25Mgn/0

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• 70% decrease in insulin secretion during hyperglycemic clamp studies
• blood glucose concentration is increased by about 50% compared to heterozygous Gcktm1.1Mgn mice
• under fasting conditions, have a 25% increase in blood glucose concentration, without differences in basal insulin concentration
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced by about 60 and 70%, respectively
• net glycogen synthesis in liver is reduced by about 50% during hyperglycemic clamp studies

endocrine/exocrine glands
• 70% decrease in insulin secretion during hyperglycemic clamp studies

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826


Mouse Genome Informatics
cn5
    Gcktm1.1Mgn/Gcktm1.1Mgn
Tg(Alb-cre)21Mgn/0

involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• secrete 70% less insulin in response to glucose stimulus
• 10% increase in fed blood glucose concentration
• post-absorptive (fed) plasma insulin concentrations twice that of controls
• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced
• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies
• mild insulin resistance

endocrine/exocrine glands
• secrete 70% less insulin in response to glucose stimulus

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:51826