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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)T29-1Stl
transgene insertion T29-1, Susumu Tonegawa
MGI:2177650
Summary 16 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gria2tm1.1Bvis/Gria2tm1.1Bvis
Tg(Camk2a-cre)T29-1Stl/0
129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl MGI:5694583
cn2
Itga3tm1Rdav/Itga3tm1Rdav
Tg(Camk2a-cre)T29-1Stl/0
B6.Cg-Itga3tm1Rdav Tg(Camk2a-cre)T29-1Stl MGI:3843051
cn3
Gabrb3tm2.1Geh/Gabrb3tm2.1Geh
Tg(Camk2a-cre)T29-1Stl/?
involves: 129 * BALB/c * C57BL/6 * SJL MGI:3767262
cn4
Crebbptm1.2Ltz/Crebbptm1.2Ltz
Tg(Camk2a-cre)T29-1Stl/0
involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J MGI:4941348
cn5
Grin1tm2Stl/Grin1tm2Stl
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S4/SvJae * BALB/c * C57BL/6 MGI:3581524
cn6
Ckap5tm1.1Eba/Ckap5tm1.1Eba
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL * C57BL/6J MGI:5570200
cn7
Grin2btm1.1Jlbr/Grin2btm1.1Jlbr
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6 MGI:4443330
cn8
Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S7/SvEvBrd * BALB/c * C57BL MGI:4943741
cn9
Ssbtm1Rjma/Ssbtm2.1Rjma
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S/SvEv * BALB/c * C57BL * C57BL/6 MGI:5569497
cn10
Arpc3tm1Ssod/Arpc3tm1Ssod
Tg(Camk2a-cre)T29-1Stl/0
involves: BALB/c * C57BL MGI:5509191
cn11
Tg(ACTB-MAP2K1*K97M)1Stl/0
Tg(Camk2a-cre)T29-1Stl/0
involves: BALB/c * C57BL/6 MGI:3707564
cn12
Drd1tm2.1Stl/Drd1tm2.1Stl
Drd5tm1.1Stl/Drd5tm1.1Stl
Tg(Camk2a-cre)T29-1Stl/0
involves: BALB/c * C57BL * C57BL/6 MGI:5603926
cn13
Crbntm1.1Jjh/Crbntm1.1Jjh
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 MGI:5302203
cn14
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 * CBA MGI:3045186
cn15
Grin1tm2Stl/Grin1tm2Stl
Tg(Actb-tTA)1Jzt/0
Tg(Camk2a-cre)T29-1Stl/0
Tg(tetO-Grin1/GFP)1Jzt/0
involves: C57BL/6 * CBA MGI:3038603
cn16
Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 * CBA MGI:3045183


Genotype
MGI:5694583
cn1
Allelic
Composition
Gria2tm1.1Bvis/Gria2tm1.1Bvis
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
129S6.Cg-Gria2tm1.1Bvis Tg(Camk2a-cre)T29-1Stl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm1.1Bvis mutation (0 available); any Gria2 mutation (12 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in CA1 after high frequency stimulation (J:223717)
• long term depression is unaffected (J:223717)
• in CA1 after high frequency stimulation (J:223717)
• long term depression is unaffected (J:223717)

behavior/neurological
• initial learning affected more than subsequent learning (NMDAR receptor vs NMDAR receptor independent) (J:223717)
• initial learning affected more than subsequent learning (NMDAR receptor vs NMDAR receptor independent) (J:223717)
• long term contextual fear conditioning is impaired (J:223717)
• dorsal hippocampal lesions also impair contextual fear conditioning (J:223717)
• pre-exposure to context fails to enhance fear conditioning (J:223717)
• short term memory remains intact (J:223717)
• long term contextual fear conditioning is impaired (J:223717)
• dorsal hippocampal lesions also impair contextual fear conditioning (J:223717)
• pre-exposure to context fails to enhance fear conditioning (J:223717)
• short term memory remains intact (J:223717)
• tested using a Morris water maze (J:223717)
• tested using a Morris water maze (J:223717)
• impaired as tested using a radial maze (J:223717)
• spatial working memory not affected (J:223717)
• impaired as tested using a radial maze (J:223717)
• spatial working memory not affected (J:223717)




Genotype
MGI:3843051
cn2
Allelic
Composition
Itga3tm1Rdav/Itga3tm1Rdav
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
B6.Cg-Itga3tm1Rdav Tg(Camk2a-cre)T29-1Stl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Rdav mutation (1 available); any Itga3 mutation (13 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a nonmatch-to-place T-maze assay, mice exhibit impaired working memory following a 20 second delay between trials (J:147820)
• however, mice trained in a Morris water maze perform normally (J:147820)
• in a nonmatch-to-place T-maze assay, mice exhibit impaired working memory following a 20 second delay between trials (J:147820)
• however, mice trained in a Morris water maze perform normally (J:147820)

nervous system
• N-methyl-D-aspartic acid receptor-dependent long term potentiation (LTP) is severely impaired compared to in wild-type mice (J:147820)
• however, glutamate receptor-dependent and high frequency-stimulated LTP are normal (J:147820)
• N-methyl-D-aspartic acid receptor-dependent long term potentiation (LTP) is severely impaired compared to in wild-type mice (J:147820)
• however, glutamate receptor-dependent and high frequency-stimulated LTP are normal (J:147820)




Genotype
MGI:3767262
cn3
Allelic
Composition
Gabrb3tm2.1Geh/Gabrb3tm2.1Geh
Tg(Camk2a-cre)T29-1Stl/?
Genetic
Background
involves: 129 * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrb3tm2.1Geh mutation (1 available); any Gabrb3 mutation (7 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born at expected Mendelian frequency (J:127877)
• no cleft palate found (J:127877)
• about 30% die between 15 and 25 days after birth (J:127877)
• 72% of mice that died prematurely were male (J:127877)
• born at expected Mendelian frequency (J:127877)
• no cleft palate found (J:127877)
• about 30% die between 15 and 25 days after birth (J:127877)
• 72% of mice that died prematurely were male (J:127877)

behavior/neurological
• hyperresponsive to human contact (J:127877)
• hyperresponsive to human contact (J:127877)
• less sensitive to the sedative/hypnotic effects of etomidate (J:127877)
• less sensitive to the sedative/hypnotic effects of etomidate (J:127877)
• average food consumption was greater in mutant over control (J:127877)
• average food consumption was greater in mutant over control (J:127877)
• the greater total activity in home cage (J:127877)
• the greater total activity in home cage (J:127877)
• failed to care for pups (J:127877)
• failed to care for pups (J:127877)
• did not produce copulation plug when mated with superovulated females (J:127877)
• did not produce copulation plug when mated with superovulated females (J:127877)
• appeared to be "frozen" in their home cage (J:127877)
• appeared to be "frozen" in their home cage (J:127877)

nervous system
• appeared to be "frozen" in their home cage (J:127877)
• appeared to be "frozen" in their home cage (J:127877)

reproductive system
• four out of six female either did not produce any offspring or produced letters infrequently (J:127877)
• four out of six female either did not produce any offspring or produced letters infrequently (J:127877)
• reduced number of mating (J:127877)
• reduced number of mating (J:127877)

growth/size/body
• some mutant adult mice became obese (J:127877)
• some mutant adult mice became obese (J:127877)




Genotype
MGI:4941348
cn4
Allelic
Composition
Crebbptm1.2Ltz/Crebbptm1.2Ltz
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1.2Ltz mutation (0 available); any Crebbp mutation (23 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal anxiety levels, fear conditioning, and spatial navigation (J:168984)
• mice exhibit normal anxiety levels, fear conditioning, and spatial navigation (J:168984)
• after 3 consecutive days in the same arena, mice exhibit slightly less locomotor habituation compared with wild-type mice (J:168984)
• after 3 consecutive days in the same arena, mice exhibit slightly less locomotor habituation compared with wild-type mice (J:168984)
• mice exhibit impaired long term recognition memory compared with wild-type mice (J:168984)
• mice exhibit impaired long term recognition memory compared with wild-type mice (J:168984)

nervous system
N
• neuronal viability is normal (J:168984)
• neuronal viability is normal (J:168984)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rubinstein-Taybi Syndrome 1; RSTS1 180849 J:168984




Genotype
MGI:3581524
cn5
Allelic
Composition
Grin1tm2Stl/Grin1tm2Stl
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm2Stl mutation (1 available); any Grin1 mutation (18 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired hippocampus-dependent, but not hippocampus-independent, fear memory that can be rescued with enriched training (J:60730)
• impaired hippocampus-dependent, but not hippocampus-independent, fear memory that can be rescued with enriched training (J:60730)
• impaired olfactory-discrimination memory that can be rescued with enriched training (J:60730)
• impaired olfactory-discrimination memory that can be rescued with enriched training (J:60730)
• deficit in novel object recognition memory that can be partially rescued with enriched training (J:60730)
• deficit in novel object recognition memory that can be partially rescued with enriched training (J:60730)
• impaired spatial memory in the hidden-platform Morris water maze test, with some progressive improvement in escape latencies but unimpaired nonspatial learning (J:37457)
• impaired spatial memory in the hidden-platform Morris water maze test, with some progressive improvement in escape latencies but unimpaired nonspatial learning (J:37457)

nervous system
• lack the slow component of the excitatory postsynaptic current mediated by NMDA receptors (J:37457)
• lack the slow component of the excitatory postsynaptic current mediated by NMDA receptors (J:37457)
• lack the slow component of the excitatory postsynaptic current mediated by NMDA receptors, however postsynaptic AMPA receptors as well as presynaptic terminals operate normally (J:37457)
• lack the slow component of the excitatory postsynaptic current mediated by NMDA receptors, however postsynaptic AMPA receptors as well as presynaptic terminals operate normally (J:37457)
• lack long term potentiation in the CA1 synapses (J:37457)
• lack long term potentiation in the CA1 synapses (J:37457)




Genotype
MGI:5570200
cn6
Allelic
Composition
Ckap5tm1.1Eba/Ckap5tm1.1Eba
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ckap5tm1.1Eba mutation (0 available); any Ckap5 mutation (21 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal balance, coordination and endurance on a rotarod, gait, anxiety in the elevated zero maze, and passive avoidance (J:205779)
• mice exhibit normal balance, coordination and endurance on a rotarod, gait, anxiety in the elevated zero maze, and passive avoidance (J:205779)
• mutants exhibit a decrease in marble burying, burying few if any marbles compared to controls which bury 30% of marbles (J:205779)
• mutants exhibit a decrease in marble burying, burying few if any marbles compared to controls which bury 30% of marbles (J:205779)
• mutants exhibit almost twice as much activity over a one hour time period than controls in the open field test, however, when activity is recorded over 5 minute intervals, controls show a decrease in activity over time that is not seen in mutants, indicating that mutants have impaired short term habituation to spatial stimuli (J:205779)
• mutants exhibit almost twice as much activity over a one hour time period than controls in the open field test, however, when activity is recorded over 5 minute intervals, controls show a decrease in activity over time that is not seen in mutants, indicating that mutants have impaired short term habituation to spatial stimuli (J:205779)
• mutants exhibit almost twice as much activity over a one hour time period than controls in the open field test (J:205779)
• mutants exhibit almost twice as much activity over a one hour time period than controls in the open field test (J:205779)
• mutant males exhibit a higher proportion of high frequency of ultrasonic vocalizations (USVs) compared to controls which show a higher proportion of low frequency USVs (J:205779)
• increase in vocalization and an increase in high frequency USVs indicates altered response to sexual or pheromonal olfactory stimuli (J:205779)
• mutant males exhibit a higher proportion of high frequency of ultrasonic vocalizations (USVs) compared to controls which show a higher proportion of low frequency USVs (J:205779)
• increase in vocalization and an increase in high frequency USVs indicates altered response to sexual or pheromonal olfactory stimuli (J:205779)
• mutant males placed next to a female mouse vocalize more than controls (J:205779)
• mutant males placed next to a female mouse vocalize more than controls (J:205779)

nervous system
• mice older than 4 months of age exhibit late onset morphological changes outside the CA1 region of the hippocampus and behavioral defects (J:205779)
• mice older than 4 months of age exhibit late onset morphological changes outside the CA1 region of the hippocampus and behavioral defects (J:205779)
• decrease (less than 20%) in the thickness of the CA1 stratum pyramidale in mutants older than 45 days (J:205779)
• decrease (less than 20%) in the thickness of the CA1 stratum pyramidale in mutants older than 45 days (J:205779)
• spine density in apical dendrites of CA1 pyramidal neurons is about 70% of control in mice younger than 3 months of age (J:205779)
• spine density in apical dendrites of CA1 pyramidal neurons is about 70% of control in mice younger than 3 months of age (J:205779)
• spine density in apical dendrites of CA1 pyramidal neurons is about 70% of control in mice younger than 3 months of age (J:205779)
• spine density in apical dendrites of CA1 pyramidal neurons is about 70% of control in mice younger than 3 months of age (J:205779)
• reduction in granule assembly and translation of granule RNAs in cultured hippocampal neurons (J:205779)
• reduction in granule assembly and translation of granule RNAs in cultured hippocampal neurons (J:205779)
• input-out curves of field excitatory postsynaptic potentials from the CA1 region of the stratum radiatum in hippocampal slices evoked by stimulation of Schaffer collateral axons show reduced amplitudes and slopes, indicating reduced basal excitatory transmission (J:205779)
• field responses in the presence of GABAzine, a GABA antagonist, are smaller in mutants than in controls (J:205779)
• input-out curves of field excitatory postsynaptic potentials from the CA1 region of the stratum radiatum in hippocampal slices evoked by stimulation of Schaffer collateral axons show reduced amplitudes and slopes, indicating reduced basal excitatory transmission (J:205779)
• field responses in the presence of GABAzine, a GABA antagonist, are smaller in mutants than in controls (J:205779)
• short-term potentiation in evoked field potentials is normal, but mutants are unable to maintain LTP of evoked potentials (J:205779)
• short-term potentiation in evoked field potentials is normal, but mutants are unable to maintain LTP of evoked potentials (J:205779)




Genotype
MGI:4443330
cn7
Allelic
Composition
Grin2btm1.1Jlbr/Grin2btm1.1Jlbr
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2btm1.1Jlbr mutation (0 available); any Grin2b mutation (8 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• CA1 pyramidal neurons exhibit lower spine density of dendrites compared to in wild-type mice (J:159387)
• CA1 pyramidal neurons exhibit lower spine density of dendrites compared to in wild-type mice (J:159387)
• NMDAR-evoked excitatory postsynaptic current (eEPSC) decay time constants are almost twice as fast as in wild-type mice (J:159387)
• NMDAR-eEPSC amplitude is slightly reduced compared to in wild-type mice (J:159387)
• unlike in wild-type mice, Ro 25-6981 fails to inhibit eEPSC (J:159387)
• NMDAR-evoked excitatory postsynaptic current (eEPSC) decay time constants are almost twice as fast as in wild-type mice (J:159387)
• NMDAR-eEPSC amplitude is slightly reduced compared to in wild-type mice (J:159387)
• unlike in wild-type mice, Ro 25-6981 fails to inhibit eEPSC (J:159387)
• unlike in wild-type mice, no increase in field excitatory postsynaptic potential (fEPSP) is observed under a protocol designed to evoke modest, subsaturating long term potentiation (J:159387)
• under a protocol designed to produce saturating long term potentiation, mice fail to exhibit a decrease in fEPSP during the first time point compared with similarly treated wild-type mice (J:159387)
• under a long term depression protocol, fEPSP slopes fail to decrease as in similarly treated wild-type mice (J:159387)
• under a long term depression protocol with DL-AP-5 co-application with glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC), mice exhibit an increase in the fEPSC slope unlike in wild-type mice and an AP-5 washout with another round of stimulation does not produce a lasting decrease in fEPSP slope as observed in similarly treated wild-type mice (J:159387)
• unlike in wild-type mice, no increase in field excitatory postsynaptic potential (fEPSP) is observed under a protocol designed to evoke modest, subsaturating long term potentiation (J:159387)
• under a protocol designed to produce saturating long term potentiation, mice fail to exhibit a decrease in fEPSP during the first time point compared with similarly treated wild-type mice (J:159387)
• under a long term depression protocol, fEPSP slopes fail to decrease as in similarly treated wild-type mice (J:159387)
• under a long term depression protocol with DL-AP-5 co-application with glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC), mice exhibit an increase in the fEPSC slope unlike in wild-type mice and an AP-5 washout with another round of stimulation does not produce a lasting decrease in fEPSP slope as observed in similarly treated wild-type mice (J:159387)
• unlike in wild-type mice, no increase in field excitatory postsynaptic potential (fEPSP) is observed under a protocol designed to evoke modest, subsaturating long term potentiation (J:159387)
• under a protocol designed to produce saturating long term potentiation, mice fail to exhibit a decrease in fEPSP during the first time point compared with similarly treated wild-type mice (J:159387)
• unlike in wild-type mice, no increase in field excitatory postsynaptic potential (fEPSP) is observed under a protocol designed to evoke modest, subsaturating long term potentiation (J:159387)
• under a protocol designed to produce saturating long term potentiation, mice fail to exhibit a decrease in fEPSP during the first time point compared with similarly treated wild-type mice (J:159387)
• application of the glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC) does not produce long term depression unlike in wild-type mice (J:159387)
• application of the glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC) does not produce long term depression unlike in wild-type mice (J:159387)
• under a long term depression protocol, fEPSP slopes fail to decrease as in similarly treated wild-type mice (J:159387)
• under a long term depression protocol with DL-AP-5 co-application with glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC), mice exhibit an increase in the fEPSC slope unlike in wild-type mice and an AP-5 washout with another round of stimulation does not produce a lasting decrease in fEPSP slope as observed in similarly treated wild-type mice (J:159387)
• under a long term depression protocol, fEPSP slopes fail to decrease as in similarly treated wild-type mice (J:159387)
• under a long term depression protocol with DL-AP-5 co-application with glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC), mice exhibit an increase in the fEPSC slope unlike in wild-type mice and an AP-5 washout with another round of stimulation does not produce a lasting decrease in fEPSP slope as observed in similarly treated wild-type mice (J:159387)

behavior/neurological
• in a hidden platform Morris water maze but not when the platform is visible (J:159387)
• in a hidden platform Morris water maze but not when the platform is visible (J:159387)
• in a T maze, mice exhibit fewer spontaneous alternations compared with wild-type mice (J:159387)
• in a T maze, mice exhibit fewer spontaneous alternations compared with wild-type mice (J:159387)
• mice exhibit less freezing during retrieval of a trace-conditioned fear memory compared with similarly treated wild-type mice (J:159387)
• however, mice exhibit normal delay-conditioned fear memory and freezing during conditioning of before tone presentation (J:159387)
• mice exhibit less freezing during retrieval of a trace-conditioned fear memory compared with similarly treated wild-type mice (J:159387)
• however, mice exhibit normal delay-conditioned fear memory and freezing during conditioning of before tone presentation (J:159387)
• in a hidden platform Morris water maze, mice exhibit a longer latency in finding a hidden platform and spend less time in a platform quadrant compared with wild-type mice (J:159387)
• however, mice exhibit normal performance during visible platform training (J:159387)
• in a hidden platform Morris water maze, mice exhibit a longer latency in finding a hidden platform and spend less time in a platform quadrant compared with wild-type mice (J:159387)
• however, mice exhibit normal performance during visible platform training (J:159387)
• in a hidden platform Morris water maze, mice swim slower than wild-type mice (J:159387)
• however, swimming is normal when the platform is visible (J:159387)
• in a hidden platform Morris water maze, mice swim slower than wild-type mice (J:159387)
• however, swimming is normal when the platform is visible (J:159387)

homeostasis/metabolism
• unlike in wild-type mice, Ro 25-6981 fails to inhibit evoked excitatory postsynaptic current (eEPSC) (J:159387)
• under a long term depression protocol with DL-AP-5 co-application with glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC), mice exhibit an increase in the fEPSC slope unlike in wild-type mice and an AP-5 washout with another round of stimulation does not produce a lasting decrease in fEPSP slope as observed in similarly treated wild-type mice (J:159387)
• application of tPDC does not produce long term depression unlike in wild-type mice (J:159387)
• however, DL-AP-5 inhibits eEPSP as in wild-type mice (J:159387)
• unlike in wild-type mice, Ro 25-6981 fails to inhibit evoked excitatory postsynaptic current (eEPSC) (J:159387)
• under a long term depression protocol with DL-AP-5 co-application with glutamate transporter inhibitor L-trans-pyrrolidine-2,4-dicarboxylic acid (tPDC), mice exhibit an increase in the fEPSC slope unlike in wild-type mice and an AP-5 washout with another round of stimulation does not produce a lasting decrease in fEPSP slope as observed in similarly treated wild-type mice (J:159387)
• application of tPDC does not produce long term depression unlike in wild-type mice (J:159387)
• however, DL-AP-5 inhibits eEPSP as in wild-type mice (J:159387)




Genotype
MGI:4943741
cn8
Allelic
Composition
Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129S7/SvEvBrd * BALB/c * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (27 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the cortex of the brain at 12 months of age (J:167724)
• in the cortex of the brain at 12 months of age (J:167724)
• decrease in spine densities of apical oblique and basal shaft dendrites of pyramidal neurons in the cortex and in the CA1 region of the hippocampus at 18 months but not at 12 months of age (J:167724)
• decrease in spine densities of apical oblique and basal shaft dendrites of pyramidal neurons in the cortex and in the CA1 region of the hippocampus at 18 months but not at 12 months of age (J:167724)
• expression analysis indicates an age dependent decrease in synaptic density (J:167724)
• expression analysis indicates an age dependent decrease in synaptic density (J:167724)
• significant increase in apoptotic cells in the cortex and hippocampus at 24 months but not at 18 months of age (J:167724)
• significant increase in apoptotic cells in the cortex and hippocampus at 24 months but not at 18 months of age (J:167724)
• significantly lower levels of sulfatide, galactosylceramide, cholesterol and triglyceride in the cortex of the brain at 12 months of age (J:167724)
• amyloid-beta levels are decreased in the hippocampus at 18 months of age, indicating that the neurodegeneration likely occurs by an amyloid-beta independent mechanism (J:167724)
• significantly lower levels of sulfatide, galactosylceramide, cholesterol and triglyceride in the cortex of the brain at 12 months of age (J:167724)
• amyloid-beta levels are decreased in the hippocampus at 18 months of age, indicating that the neurodegeneration likely occurs by an amyloid-beta independent mechanism (J:167724)
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age (J:167724)
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age (J:167724)
• severely reduced in hippocampal slices at 18 months of age (J:167724)
• severely reduced in hippocampal slices at 18 months of age (J:167724)

behavior/neurological
• exhibit significantly less freezing time than controls at 18 months of age (J:167724)
• exhibit significantly less freezing time than controls at 18 months of age (J:167724)
• exhibit significantly less freezing time than controls at 18 months of age (J:167724)
• exhibit significantly less freezing time than controls at 18 months of age (J:167724)
• develops by 13 months of age (J:167724)
• develops by 13 months of age (J:167724)
• at 18 months of age (J:167724)
• at 18 months of age (J:167724)
• in an open field test at 18 months of age (J:167724)
• in an open field test at 18 months of age (J:167724)

homeostasis/metabolism
• significantly lower levels of sulfatide and galactosylceramide in the cortex of the brain at 12 months of age (J:167724)
• significantly lower levels of sulfatide and galactosylceramide in the cortex of the brain at 12 months of age (J:167724)
• in the cortex of the brain at 12 months of age (J:167724)
• in the cortex of the brain at 12 months of age (J:167724)
• in the cortex of the brain at 12 months of age (J:167724)
• in the cortex of the brain at 12 months of age (J:167724)

immune system
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age (J:167724)
• increase in reactive astrocytes and microglial activation in the CA1 region of the hippocampus and in the dentate gyrus but not in the CA3 region of the hippocampus at 18 months of age (J:167724)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:167724




Genotype
MGI:5569497
cn9
Allelic
Composition
Ssbtm1Rjma/Ssbtm2.1Rjma
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: 129S/SvEv * BALB/c * C57BL * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbtm1Rjma mutation (0 available); any Ssb mutation (15 available)
Ssbtm2.1Rjma mutation (0 available); any Ssb mutation (15 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• after 5 weeks (J:207687)
• rapid decline from 13 to 25 weeks, slowed decline afterward (J:207687)
• at 59 to 79 weeks (J:207687)
• after 5 weeks (J:207687)
• rapid decline from 13 to 25 weeks, slowed decline afterward (J:207687)
• at 59 to 79 weeks (J:207687)
• postnatal loss of forebrain mass at 16 and 32 weeks (J:207687)
• postnatal loss of forebrain mass at 16 and 32 weeks (J:207687)
• progressive cell loss (J:207687)
• progressive cell loss (J:207687)
• loss of cortical cytoarchitecture at 16 and 32 weeks (J:207687)
• loss of cortical cytoarchitecture at 16 and 32 weeks (J:207687)
• progressive neurodegeneration in the cerebral cortex (starting at 16 weeks) and hippocampus starting (J:207687)
• severely diminished at 65 weeks (J:207687)
• progressive neurodegeneration in the cerebral cortex (starting at 16 weeks) and hippocampus starting (J:207687)
• severely diminished at 65 weeks (J:207687)
• decrease in neuronal density at 16 and 32 weeks (J:207687)
• decrease in neuronal density at 16 and 32 weeks (J:207687)
• in the CA1 and subiculum (J:207687)
• however, the CA3 and dentate gyrus are relatively spared (J:207687)
• in the CA1 and subiculum (J:207687)
• however, the CA3 and dentate gyrus are relatively spared (J:207687)
• progressive neurodegeneration in the cerebral cortex and hippocampus (J:207687)
• progressive neurodegeneration in the cerebral cortex and hippocampus (J:207687)




Genotype
MGI:5509191
cn10
Allelic
Composition
Arpc3tm1Ssod/Arpc3tm1Ssod
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: BALB/c * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arpc3tm1Ssod mutation (0 available); any Arpc3 mutation (7 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal basal startle responses (J:196577)
• mice exhibit normal basal startle responses (J:196577)
• in a novel object recognition test, adolescent and adult mice exhibit disrupted episodic learning and memory compared with control mice (J:196577)
• early and pronounced deficit in short-term, long-term and remote memory in a novel object recognition test (J:196577)
• in a novel object recognition test, adolescent and adult mice exhibit disrupted episodic learning and memory compared with control mice (J:196577)
• early and pronounced deficit in short-term, long-term and remote memory in a novel object recognition test (J:196577)
• impaired in adolescent and adult mice in a novel object recognition test (J:196577)
• impaired in adolescent and adult mice in a novel object recognition test (J:196577)
• impaired in adolescent and adult mice in a novel object recognition test (J:196577)
• impaired in adolescent and adult mice in a novel object recognition test (J:196577)
• impaired in adult, but not adolescent, mice in a Y-maze (J:196577)
• impaired in adult, but not adolescent, mice in a Y-maze (J:196577)
• in adult, but not adolescent, mice (J:196577)
• in adult, but not adolescent, mice (J:196577)
• adult, but not adolescent, mice in the home cage (J:196577)
• adult, but not adolescent, mice in the home cage (J:196577)
• in adult, but not adolescent, mice (J:196577)
• in adult, but not adolescent, mice (J:196577)
• reduced social interaction of in adult, but not adolescent, mice (J:196577)
• reduced social interaction of in adult, but not adolescent, mice (J:196577)

nervous system
• progressive loss of spine at P120 (J:196577)
• neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons (J:196577)
• progressive loss of spine at P120 (J:196577)
• neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons (J:196577)
• at 4 months, mice exhibit a loss of synapses onto spines in the stratum radiatum of the hippocampus and cerebral cortex compared with control mice (J:196577)
• at 4 months, mice exhibit a loss of synapses onto spines in the stratum radiatum of the hippocampus and cerebral cortex compared with control mice (J:196577)
• in adolescent and adult mice (J:196577)
• in adolescent and adult mice (J:196577)




Genotype
MGI:3707564
cn11
Allelic
Composition
Tg(ACTB-MAP2K1*K97M)1Stl/0
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ACTB-MAP2K1*K97M)1Stl mutation (1 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• when tested for retention 24 hours after contextual fear conditioning, mutants show reduced levels of freezing relative to wild-type (mutant - 36.6% vs wild-type - 57.5%) (J:88546)
• when tested for retention 24 hours after contextual fear conditioning, mutants show reduced levels of freezing relative to wild-type (mutant - 36.6% vs wild-type - 57.5%) (J:88546)
• 48 hours after a cued fear conditioning test, where a tone was the conditioned stimulus, mutants show a low level of freezing prior to tone presentation, indicating impairment of contextual memory (J:88546)
• 48 hours after a cued fear conditioning test, where a tone was the conditioned stimulus, mutants show a low level of freezing prior to tone presentation, indicating impairment of contextual memory (J:88546)
• in the Morris water maze test, mutants showed a tendency toward longer escape latencies compared to wild-type (J:88546)
• in probe trials with the platform hidden, mutant mice spend less time searching the target quadrant, and show less accurate identification of the precise platform location by having a reduced number of platform crossings (J:88546)
• in the Morris water maze test, mutants showed a tendency toward longer escape latencies compared to wild-type (J:88546)
• in probe trials with the platform hidden, mutant mice spend less time searching the target quadrant, and show less accurate identification of the precise platform location by having a reduced number of platform crossings (J:88546)

nervous system
• field EPSPs in mutant hippocampal slice preparations return to levels near unstimulated levels by 3 hours posttetaniziation, while in control slices the fEPSPs (ie. late LTP remains elevated (J:88546)
• field EPSPs in mutant hippocampal slice preparations return to levels near unstimulated levels by 3 hours posttetaniziation, while in control slices the fEPSPs (ie. late LTP remains elevated (J:88546)
• application of 4 trains of tetanic stimulation at 5 minute intervals, elicits long-lasting (>3 hours) potentiation in control hippocampal slices, but in mutants potentiation is unstable and decays progressively (J:88546)
• mutants display selective impairment in translational component of late-LTP (L-LTP); the defect is transcription-independent, translation-dependent, as shown by difference in inhibition kinetics of actinomycin-D (transcriptional inhibitor) and anisomycin (translational inhibitor) (J:88546)
• application of 4 trains of tetanic stimulation at 5 minute intervals, elicits long-lasting (>3 hours) potentiation in control hippocampal slices, but in mutants potentiation is unstable and decays progressively (J:88546)
• mutants display selective impairment in translational component of late-LTP (L-LTP); the defect is transcription-independent, translation-dependent, as shown by difference in inhibition kinetics of actinomycin-D (transcriptional inhibitor) and anisomycin (translational inhibitor) (J:88546)

homeostasis/metabolism
• ERK activation in the forebrain is inhibited, causing selective deficits in hippocampal memory retention and translation-dependent phase of late-LTP (J:88546)
• ERK activation in the forebrain is inhibited, causing selective deficits in hippocampal memory retention and translation-dependent phase of late-LTP (J:88546)




Genotype
MGI:5603926
cn12
Allelic
Composition
Drd1tm2.1Stl/Drd1tm2.1Stl
Drd5tm1.1Stl/Drd5tm1.1Stl
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: BALB/c * C57BL * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm2.1Stl mutation (1 available); any Drd1 mutation (36 available)
Drd5tm1.1Stl mutation (1 available); any Drd5 mutation (13 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit deficits in contextual fear conditioning (J:211355)
• mice exhibit reduced freezing levels in 24 hour fear memory test, however, conditioning to tone is normal in an amygdala-dependent cued-fear conditioning protocol (J:211355)
• mice exhibit deficits in contextual fear conditioning (J:211355)
• mice exhibit reduced freezing levels in 24 hour fear memory test, however, conditioning to tone is normal in an amygdala-dependent cued-fear conditioning protocol (J:211355)

nervous system
• impaired late phase long term potentiation (L-LTP) at the medial perforant path-dentate gyrus synapse (J:211355)
• mice exhibit a reduced fEPSP (excitatory postsynaptic potential) slope following a theta burst used to induce L-LTP as compared to controls (J:211355)
• impaired late phase long term potentiation (L-LTP) at the medial perforant path-dentate gyrus synapse (J:211355)
• mice exhibit a reduced fEPSP (excitatory postsynaptic potential) slope following a theta burst used to induce L-LTP as compared to controls (J:211355)




Genotype
MGI:5302203
cn13
Allelic
Composition
Crbntm1.1Jjh/Crbntm1.1Jjh
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crbntm1.1Jjh mutation (1 available); any Crbn mutation (6 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal basal locomotion and anxiety-like behaviors (J:179427)
• mice exhibit normal basal locomotion and anxiety-like behaviors (J:179427)




Genotype
MGI:3045186
cn14
Allelic
Composition
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Jzt mutation (0 available); any Psen1 mutation (22 available)
Psen2tm1Ber mutation (0 available); any Psen2 mutation (5 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• by 10 months of age mutants have impaired performance in a novel object recognition test (J:90685)
• by 10 months of age mutants have impaired performance in a novel object recognition test (J:90685)
• by 10 months of age some mutants show increased activity in an open field test (J:90685)
• by 10 months of age some mutants show increased activity in an open field test (J:90685)

cellular
• a dramatic increase in apoptosis is seen in the degenerating forebrain (J:90685)
• a dramatic increase in apoptosis is seen in the degenerating forebrain (J:90685)

growth/size/body
• by 10 months of age mutant mice start to show reduced body weights compared to wild-type (J:90685)
• by 10 months of age mutant mice start to show reduced body weights compared to wild-type (J:90685)

nervous system
• the lateral ventricles are immensely enlarged compared to wild-type or single knockout mice (J:90685)
• the lateral ventricles are immensely enlarged compared to wild-type or single knockout mice (J:90685)
• the third ventricle is immensely enlarged compared to wild-type or single knockout mice (J:90685)
• the third ventricle is immensely enlarged compared to wild-type or single knockout mice (J:90685)
• the thickness of the corpus callosum is about a third that of controls (J:90685)
• the thickness of the corpus callosum is about a third that of controls (J:90685)
• the thickness of the molecular layers between the CA1 pyramidal cells and dentate gyrus is significantly reduced (J:90685)
• the thickness of the molecular layers between the CA1 pyramidal cells and dentate gyrus is significantly reduced (J:90685)
• the cortex is about half the normal thickness and the 6 layers can no longer be distinguished (J:90685)
• the cortex is about half the normal thickness and the 6 layers can no longer be distinguished (J:90685)
• increased Gfap expression indicates that reactive astrogliosis occurs along with forebrain degeneration (J:90685)
• increased Gfap expression indicates that reactive astrogliosis occurs along with forebrain degeneration (J:90685)
• changes in the expression of several markers indicate that neuronal atrophy occurs along with forebrain degeneration (J:90685)
• changes in the expression of several markers indicate that neuronal atrophy occurs along with forebrain degeneration (J:90685)
• degeneration is seen in the forebrain (J:90685)
• degeneration is seen in the forebrain (J:90685)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 4 606889 J:90685
Alzheimer Disease; AD 104300 J:90685




Genotype
MGI:3038603
cn15
Allelic
Composition
Grin1tm2Stl/Grin1tm2Stl
Tg(Actb-tTA)1Jzt/0
Tg(Camk2a-cre)T29-1Stl/0
Tg(tetO-Grin1/GFP)1Jzt/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm2Stl mutation (1 available); any Grin1 mutation (18 available)
Tg(Actb-tTA)1Jzt mutation (0 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
Tg(tetO-Grin1/GFP)1Jzt mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• deficits in learning, memory and conditioning are seen in doxycycline treated mutants where expression of Grin1 is knocked out and expression of Grin1-GFP in the CA1 region of the hippocampus is blocked but deficits in learning, memory and conditioning are not seen in untreated mutants (J:77659)
• deficits in learning, memory and conditioning are seen in doxycycline treated mutants where expression of Grin1 is knocked out and expression of Grin1-GFP in the CA1 region of the hippocampus is blocked but deficits in learning, memory and conditioning are not seen in untreated mutants (J:77659)
• with doxycycline treatment prior to or immediately after training mutants show significantly fewer freezing responses compared to untreated mutants in a retention test following a fear-conditioning task (J:77659)
• with doxycycline treatment just prior to testing (investigating the role of Grin1 in memory retrieval) no significant difference in a 1-month retention test following a fear-conditioning task is seen (J:77659)
• no difference in cued-fear conditioning behavior is seen with doxycycline treatment (J:77659)
• with doxycycline treatment prior to or immediately after training mutants show significantly fewer freezing responses compared to untreated mutants in a retention test following a fear-conditioning task (J:77659)
• with doxycycline treatment just prior to testing (investigating the role of Grin1 in memory retrieval) no significant difference in a 1-month retention test following a fear-conditioning task is seen (J:77659)
• no difference in cued-fear conditioning behavior is seen with doxycycline treatment (J:77659)
• with doxycycline treatment for 30 days in the seventh month after training mutants show severe deficits in retention of remote contextual fear memory in a 9-month contextual retention test (J:88689)
• no deficit was seen with doxycycline treatment for 7 days in the seventh month after training (J:88689)
• no difference in cued-fear conditioning behavior is seen with doxycycline treatment (J:88689)
• 2 months after stopping doxycycline treatment mutants perform normally in 1-day contextual fear retention, visual memory, open field behavior and rotorod tests (J:88689)
• with doxycycline treatment for 30 days in the seventh month after training mutants show severe deficits in retention of remote contextual fear memory in a 9-month contextual retention test (J:88689)
• no deficit was seen with doxycycline treatment for 7 days in the seventh month after training (J:88689)
• no difference in cued-fear conditioning behavior is seen with doxycycline treatment (J:88689)
• 2 months after stopping doxycycline treatment mutants perform normally in 1-day contextual fear retention, visual memory, open field behavior and rotorod tests (J:88689)
• with doxycycline treatment prior to or immediately after training mutants exhibited longer escape latency in a hidden-platform water maze compared to untreated mutants (J:77659)
• with doxycycline treatment just prior to testing (investigating the role of Grin1 in memory retrieval) no significant difference in escape latency is seen (J:77659)
• deficits in spatial learning and memory are also seen in mutants with doxycycline treatment prior to testing in the transfer test compared to untreated mutants (J:77659)
• with doxycycline treatment prior to or immediately after training mutants exhibited longer escape latency in a hidden-platform water maze compared to untreated mutants (J:77659)
• with doxycycline treatment just prior to testing (investigating the role of Grin1 in memory retrieval) no significant difference in escape latency is seen (J:77659)
• deficits in spatial learning and memory are also seen in mutants with doxycycline treatment prior to testing in the transfer test compared to untreated mutants (J:77659)

nervous system
• with doxycycline treatment excitation postsynaptic potentials are absent in the CA1 hippocampal region (J:77659)
• no long-term potentiation is observed in doxycycline treated homozygotes (J:77659)
• with doxycycline treatment excitation postsynaptic potentials are absent in the CA1 hippocampal region (J:77659)
• no long-term potentiation is observed in doxycycline treated homozygotes (J:77659)
• with a 5 day doxycycline treatment no long-term potentiation is observed in mutants (J:88689)
• with a 5 day doxycycline treatment no long-term potentiation is observed in mutants (J:88689)




Genotype
MGI:3045183
cn16
Allelic
Composition
Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Jzt mutation (0 available); any Psen1 mutation (22 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• exposure to environmental enrichment following contextual fear conditioning results in a significant increase in freezing responses during retention tests (J:73252)
• exposure to environmental enrichment following contextual fear conditioning results in a significant increase in freezing responses during retention tests (J:73252)

cellular
• environmental enrichment induces significantly less neurogenesis in the dentate gyrus of the brain in mutants compared to wild-type controls (J:73252)
• environmental enrichment induces significantly less neurogenesis in the dentate gyrus of the brain in mutants compared to wild-type controls (J:73252)

nervous system
• following environmental enrichment the number of newborn neurons in the subgranular zone and molecular layer of the dentate gyrus are 39% and 48% less respectively compared to wild-type mice (J:73252)
• following environmental enrichment the number of newborn neurons in the subgranular zone and molecular layer of the dentate gyrus are 39% and 48% less respectively compared to wild-type mice (J:73252)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:73252





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory