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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myhca-cre)1Lrsn
transgene insertion 1, Nils-Goran Larsson
MGI:2177636
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0
involves: 129P2/OlaHsd * C57BL/6Crl * FVB MGI:4415178
cn2
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0
involves: 129S1/Sv * 129X1/SvJ * FVB MGI:2177637


Genotype
MGI:4415178
cn1
Allelic
Composition
Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6Crl * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2a2tm1.1Iemr mutation (0 available); any Atp2a2 mutation (46 available)
Tg(Myhca-cre)1Lrsn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although alive at E10.5, embryos die by E11.5




Genotype
MGI:2177637
cn2
Allelic
Composition
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfamtm1Lrsn mutation (0 available); any Tfam mutation (6 available)
Tg(Myhca-cre)1Lrsn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 75% of animals die as neonates
• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene

cardiovascular system

cellular
• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

Mouse Models of Human Disease
OMIM ID Ref(s)
Kearns-Sayre Syndrome; KSS 530000 J:61372





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory