Mouse Genome Informatics
cn1
    Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0

involves: 129P2/OlaHsd * C57BL/6Crl * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• although alive at E10.5, embryos die by E11.5


Mouse Genome Informatics
cn2
    Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0

involves: 129S1/Sv * 129X1/SvJ * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• 75% of animals die as neonates
• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene

cardiovascular system

cellular
• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

Mouse Models of Human Disease
OMIM IDRef(s)
Kearns-Sayre Syndrome; KSS 530000 J:61372