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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myhca-cre)1Lrsn
transgene insertion 1, Nils-Goran Larsson
MGI:2177636
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0 		involves: 129P2/OlaHsd * C57BL/6Crl * FVB MGI:4415178
cn2
 		Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0 		involves: 129S1/Sv * 129X1/SvJ * FVB MGI:2177637


Genotype
MGI:4415178
cn1
Allelic
Composition		 Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6Crl * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2a2tm1.1Iemr mutation (0 available); any Atp2a2 mutation (76 available)
Tg(Myhca-cre)1Lrsn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:155628 )
• although alive at E10.5, embryos die by E11.5




Genotype
MGI:2177637
cn2
Allelic
Composition		 Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfamtm1Lrsn mutation (1 available); any Tfam mutation (11 available)
Tg(Myhca-cre)1Lrsn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:61372 )
• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene
neonatal lethality, incomplete penetrance ( J:61372 )
• 75% of animals die as neonates

cardiovascular system

cellular
abnormal respiratory electron transport chain ( J:61372 )
• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

growth/size/body
increased heart weight ( J:61372 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Kearns-Sayre syndrome DOID:12934 OMIM:530000
 J:61372




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory