Mouse Genome Informatics
cn1
     Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
Tg(Myhca-cre)1Lrsn/0
involves: 129P2/OlaHsd * C57BL/6Crl * FVB
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
complete embryonic lethality during organogenesis ( J:155628 )
• although alive at E10.5, embryos die by E11.5


Mouse Genome Informatics
cn2
     Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0
involves: 129S1/Sv * 129X1/SvJ * FVB
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
mortality/aging
partial neonatal lethality ( J:61372 )
• 75% of animals die as neonates
premature death ( J:61372 )
• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene

cardiovascular system

cellular
abnormal respiratory electron transport chain ( J:61372 )
• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

Mouse Models of Human Disease
 OMIM IDRef(s)
Kearns-Sayre Syndrome; KSS 530000 J:61372