Phenotypes associated with this allele

• Allele Symbol: Gabrg2^tm1Lusc
• Allele Name: targeted mutation 1, Bernhard Luscher
• Allele ID: MGI:2177608
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabrg2^tm1Lusc/Gabrg2^tm1Lusc	involves: 129P2/OlaHsd * C57BL/6	MGI:2177609

Genotype
MGI:2177609

hm1

• Allelic Composition: Gabrg2^tm1Lusc/Gabrg2^tm1Lusc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:28662 )

• most mice died within a few days of birth, although the animals had normal birth weight and peripheral organ structure

• remainder of surviving mice failed to thrive and none survived beyond P18

behavior/neurological

impaired righting response ( J:28662 )

limb grasping ( J:28662 )

abnormal gait ( J:28662 )

• described as duck walk

hyperactivity ( J:28662 )

• exceessive hyperactivity in body and limb movement following birth

nervous system

nervous system phenotype ( J:28662 )

N • no obvious alterations in brain cytoarchitecture in newborn mutant mice