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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Brca1tm2Arge
targeted mutation 2, Argiris Efstratiadis
MGI:2177209
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Brca1tm2Arge/Brca1tm2Arge 129-Brca1tm2Arge MGI:2177682
hm2
 		Brca1tm2Arge/Brca1tm2Arge B6.129-Brca1tm2Arge MGI:2177681
hm3
 		Brca1tm2Arge/Brca1tm2Arge involves: 129 MGI:5491069
hm4
 		Brca1tm2Arge/Brca1tm2Arge involves: 129 * C57BL/6 MGI:5494457
hm5
 		Brca1tm2Arge/Brca1tm2Arge involves: 129 * C57BL/6J MGI:2177678
hm6
 		Brca1tm2Arge/Brca1tm2Arge involves: 129/Sv * C57BL/6J * MF1 MGI:2177683
ht7
 		Brca1tm2Arge/Brca1tm3.1Rjbr involves: 129 * C57BL/6 MGI:5494454


Genotype
MGI:2177682
hm1
Allelic
Composition		 Brca1tm2Arge/Brca1tm2Arge
Genetic
Background		 129-Brca1tm2Arge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:69187 )
• mice develop a variety of tumors, including mammary tumors

pigmentation

growth/size/body
postnatal growth retardation ( J:69187 )
• mild growth retardation

limbs/digits/tail

reproductive system

integument

endocrine/exocrine glands




Genotype
MGI:2177681
hm2
Allelic
Composition		 Brca1tm2Arge/Brca1tm2Arge
Genetic
Background		 B6.129-Brca1tm2Arge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:69187 )
• on a predominantly C57BL/6J genetic background, less than 4% of homozygous mutants survived to term




Genotype
MGI:5491069
hm3
Allelic
Composition		 Brca1tm2Arge/Brca1tm2Arge
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:194229 )
• more than half of the mutant mice die by 10 days after MMC exposure while all similarly treated wild-type mice survive
• all mutant mice are dead by 16 days post MMC exposure

cellular
abnormal double-strand DNA break repair ( J:194229 )
• five- and three-fold decrease in homology directed repair activity in MEFs and ear fibroblasts, respectively, compared to controls

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:194229 )
• five- and three-fold decrease in homology directed repair activity in MEFs and ear fibroblasts, respectively, compared to controls
increased susceptibility to xenobiotic induced morbidity/mortality ( J:194229 )
• more than half of the mutant mice die by 10 days after MMC exposure while all similarly treated wild-type mice survive
• all mutant mice are dead by 16 days post MMC exposure




Genotype
MGI:5494457
hm4
Allelic
Composition		 Brca1tm2Arge/Brca1tm2Arge
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm




Genotype
MGI:2177678
hm5
Allelic
Composition		 Brca1tm2Arge/Brca1tm2Arge
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:69187 )
• on a (C57BL/6J x 129/Sv)F2 genetic background, only 4% of homozygous mutants survived to term




Genotype
MGI:2177683
hm6
Allelic
Composition		 Brca1tm2Arge/Brca1tm2Arge
Genetic
Background		 involves: 129/Sv * C57BL/6J * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:69187 )
• mice develop a variety of tumors, including mammary tumors

pigmentation

growth/size/body
postnatal growth retardation ( J:69187 )
• mild growth retardation

limbs/digits/tail

reproductive system

integument

endocrine/exocrine glands




Genotype
MGI:5494454
ht7
Allelic
Composition		 Brca1tm2Arge/Brca1tm3.1Rjbr
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Arge mutation (0 available); any Brca1 mutation (113 available)
Brca1tm3.1Rjbr mutation (1 available); any Brca1 mutation (113 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:177853 )
N
• mice do not exhibit increased spontaneous tumor formation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory