Phenotypes associated with this allele

• Allele Symbol: Grik1^tm1Sfh
• Allele Name: targeted mutation 1, Stephen F Heinemann
• Allele ID: MGI:2176347
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grik1^tm1Sfh/Grik1^tm1Sfh	involves: 129S/SvEv	MGI:3639301
hm2	Grik1^tm1Sfh/Grik1^tm1Sfh	involves: 129S/SvEv * C57BL/6	MGI:3639302
cx3	Grik1^tm1Sfh/Grik1^tm1Sfh Grik2^tm1Sfh/Grik2^tm1Sfh	involves: 129S/SvEv * 129S1/Sv * C57BL/6	MGI:3639308

Genotype
MGI:3639301

hm1

• Allelic Composition: Grik1^tm1Sfh/Grik1^tm1Sfh
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:96594 )

• enhanced induction of gamma oscillations in the CA3 area of the hippocampus

• increasing concentrations of kainite used as a stimulus results in epileptiform activity, interictal bursting

abnormal inhibitory postsynaptic currents ( J:66021 , J:96594 )

• spontaneous IPSC frequency increases to a lesser extent after domoate stimulation than in controls (2.2X vs 3X) (J:66021)

• use of 100nM kainate as a stimulant causes rhythmic IPSCs in the gamma frequency range (J:96594)

Genotype
MGI:3639302

hm2

• Allelic Composition: Grik1^tm1Sfh/Grik1^tm1Sfh
• Genetic Background: involves: 129S/SvEv * C57BL/6

nervous system

enhanced long-term potentiation ( J:98109 )

• theta burst stimulation causes LTP in the auditory cortex

behavior/neurological

increased chemical nociceptive threshold ( J:98109 )

• reduced licking response after subcutaneous injection of capsaicin or formalin

Genotype
MGI:3639308

cx3

• Allelic Composition: Grik1^tm1Sfh/Grik1^tm1Sfh; Grik2^tm1Sfh/Grik2^tm1Sfh
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

nervous system

abnormal inhibitory postsynaptic currents ( J:66021 )

• spontaneous IPSC frequency increases after domoate stimulation is completely eliminated in CA1 pyramidal neurons

• evoked IPSC is eliminated