Phenotypes associated with this allele

• Allele Symbol: Mif^tm1Dvd
• Allele Name: targeted mutation 1, John R David
• Allele ID: MGI:2176337
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mif^tm1Dvd/Mif^tm1Dvd	B6.129S4-Mif^tm1Dvd	MGI:3773316
hm2	Mif^tm1Dvd/Mif^tm1Dvd	involves: 129S4/SvJae * C57BL/6	MGI:2176340

Genotype
MGI:3773316

hm1

• Allelic Composition: Mif^tm1Dvd/Mif^tm1Dvd
• Genetic Background: B6.129S4-Mif^tm1Dvd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

BBN-induced bladder cancer is less aggressive in Mif^tm1Dvd/Mif^tm1Dvd mice than in wild type and does not invade muscle layers

neoplasm

decreased incidence of tumors by chemical induction ( J:126543 )

• mice treated with N-butyl-N-(-4-hydroxybutyl)-nitrosamine (BBN) develop less aggressive bladder cancer than wild-type mice, with no invasion into muscle layers as seen in wild-type

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:126543 )

• mice treated with N-butyl-N-(-4-hydroxybutyl)-nitrosamine (BBN) develop less aggressive bladder cancer than wild-type mice, with no invasion into muscle layers as seen in wild-type

Genotype
MGI:2176340

hm2

• Allelic Composition: Mif^tm1Dvd/Mif^tm1Dvd
• Genetic Background: involves: 129S4/SvJae * C57BL/6

cardiovascular system

increased susceptibility to myocardial ischemic injury ( J:213776 )

• left ventricle contractile dysfunction and myocardial necrosis is more pronounced in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts but less than in homozygous Cd74^tm1Eae hearts

increased myocardial infarct size ( J:213776 )

• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts but is smaller than in homozygous Cd74^tm1Eae hearts

immune system

decreased circulating tumor necrosis factor level ( J:52300 )

• mutants stimulated with LPS or SEB show a 50% and 65%, respectively, reduction in the plasma levels of TNF-alpha compared to wild-type

• macrophages stimulated with LPS and interferon gamma show diminished production of TNF-alpha

increased interleukin-4 secretion ( J:52300 )

• lymph node cells from L. major infected mice show higher IL-4 production after antigen stimulation than cells from wild-type

decreased susceptibility to endotoxin shock ( J:52300 )

• mutants are resistant to the lethal effects of high dose bacterial lipopolysaccharide (LPS) and Staphylococcus aureus enterotoxin B (SEB) with D-galactosamine

• however, mutants are susceptible to a combination of low-dose LPS and D-galactosamine

decreased susceptibility to bacterial infection ( J:52300 )

• mutants clear gram-negative bacteria Pseudomonas aeruginosa instilled into the trachea better than wild-type and have diminished neutrophil accumulation in their bronchoalveolar fluid compared to wild-type

increased susceptibility to parasitic infection ( J:52300 )

• mice are more susceptible to the intracellular parasite L. major than wild-type

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:213776 )

• left ventricle contractile dysfunction and myocardial necrosis is more pronounced in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts but less than in homozygous Cd74^tm1Eae hearts

increased myocardial infarct size ( J:213776 )

• infract size is greater in isolated perfused hearts during reperfusion after ischemia than in wild-type hearts but is smaller than in homozygous Cd74^tm1Eae hearts

decreased circulating tumor necrosis factor level ( J:52300 )

• mutants stimulated with LPS or SEB show a 50% and 65%, respectively, reduction in the plasma levels of TNF-alpha compared to wild-type

• macrophages stimulated with LPS and interferon gamma show diminished production of TNF-alpha