All Phenotypes Il4<tm1Kopf> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il4^tm1Kopf/Il4^tm1Kopf	involves: 129S2/SvPas	MGI:3765453
hm2	Il4^tm1Kopf/Il4^tm1Kopf	involves: 129S2/SvPas * C57BL/6	MGI:3765444
cx3	Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:4462259

Allelic Composition	Il4^tm1Kopf/Il4^tm1Kopf
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Kopf mutation (4 available); any Il4 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased eosinophil cell number ( J:113065 )

• following exposure to an antigen, mice exhibit reduced eosinophil infiltration (0.60+/-0.17x10⁵ cells/ml compared to 3.15+/-0.66x10⁵ in wild-type mice)

decreased IgE level ( J:113065 )

• IgE levels are undetectable (less than 10 ng/ml compared to 3300+/-1300 ng/ml in wild-type mice)

decreased interleukin-5 secretion ( J:113065 )

• mice fail to secrete IL-5 after cross-linking of the CD3/TCR complex

hematopoietic system

decreased eosinophil cell number ( J:113065 )

• following exposure to an antigen, mice exhibit reduced eosinophil infiltration (0.60+/-0.17x10⁵ cells/ml compared to 3.15+/-0.66x10⁵ in wild-type mice)

decreased IgE level ( J:113065 )

• IgE levels are undetectable (less than 10 ng/ml compared to 3300+/-1300 ng/ml in wild-type mice)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased IgE level ( J:14593 )

• unlike in wild-type mice, IgE levels are undetectable prior to and following immunization

decreased IgG1 level ( J:14593 )

• IgG1 levels are reduced 20-fold compared to in wild-type mice and following immunization IgG1 levels are 12-fold lower than in immunized wild-type mice

• following immunization with DNP-ovalbumin, IgG1 antibodies are 10-fold lower than in wild-type mice

increased IgG level ( J:14593 )

• following infection with N. brasiliensis, IgG2 and IgG3 levels are slightly higher than in wild-type mice

• following immunization with DNP-ovalbumin, IgG2 and IgG3 levels are 100- to 500-fold higher than in wild-type mice

decreased interleukin-10 secretion ( J:14593 )

• stimulated CD4+ T cells in vitro fail to produce IL-10

decreased interleukin-3 secretion ( J:14593 )

• in stimulated CD4+ T cells, the production of IL-3 is reduced more than 70% of wild-type value

decreased interleukin-4 secretion ( J:14593 )

• stimulated CD4+ T cells in vitro fail to produce IL-4

decreased interleukin-5 secretion ( J:14593 )

• stimulated CD4+ T cells in vitro fail to produce IL-5

abnormal response to infection ( J:14593 )

• following infection with N. brasiliensis, CD4+ T cells produce reduced levels of Th2 cytokines, increased levels of interferon-gamma, and reduced blood eosinophilia levels compared to infected wild-type mice

• however, CD8+ T cells do produce IL-5 following infection with N. brasiliensis

hematopoietic system

decreased IgE level ( J:14593 )

• unlike in wild-type mice, IgE levels are undetectable prior to and following immunization

decreased IgG1 level ( J:14593 )

• IgG1 levels are reduced 20-fold compared to in wild-type mice and following immunization IgG1 levels are 12-fold lower than in immunized wild-type mice

• following immunization with DNP-ovalbumin, IgG1 antibodies are 10-fold lower than in wild-type mice

increased IgG level ( J:14593 )

• following infection with N. brasiliensis, IgG2 and IgG3 levels are slightly higher than in wild-type mice

• following immunization with DNP-ovalbumin, IgG2 and IgG3 levels are 100- to 500-fold higher than in wild-type mice

Allelic Composition	Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4^tm1Kopf mutation (4 available); any Il4 mutation (42 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

increased mast cell number ( J:161523 )

• in the peritoneum

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

decreased IgE level ( J:161523 )

decreased IgG1 level ( J:161523 )

increased IgG2a level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

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