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Allele Symbol Allele Name Allele ID |
Mapk9tm1Flv targeted mutation 1, Richard Flavell MGI:2176243 |
| Summary |
12 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Abnormal epidermis of adult Mapk8tm1Flv/Mapk8tm1Flv and Mapk9tm1Flv/Mapk9tm1Flv mice
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• keratohyalin granules, markers of epidermal differentiation, are increased in the stratum granulosum
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• exhibit greater number of keratinocyte stem cells in skin
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• keratinocyte hyperplasia, resulting in an increased number of epithelial cell layers
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mortality from galactosamine/lipopolysaccharide (GalN/LPS)-induced liver injury is markedly decreased compared to wild-type
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• exhibit protection from galactosamine/lipopolysaccharide (GalN/LPS)-induced liver injury, showing decreased injury, mortality, and blockage of the TNF death pathway and mitochondrial death pathway (decrease in Bid cleavage, mitochondrial translocation, and cytochrome c release)
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• exhibit protection from GalN/LPS-induced liver injury
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• upon UV irradiation, mutant MEFs (mouse embryonic fibroblasts) show decreased JNK activity compared to wild-type or Mapk8-null MEFs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• exhibit no difference in response to pressure overload compared to wild-type
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• exhibit impaired differentiation of precursor CD4+ T cells into effector T helper 1 cells but not T helper 2 cells
• even in the presence of IL-2, precursor CD4+ T cells fail to differentiate into Th1 cells that produce large amounts of the effector cytokine IFN-gamma
• IFN-gamma production is reduced in effector Th1 cells; impairment of IFN-gamma production in Th1 cells is caused by insufficient IL-12 stimulated differentiation of the precursor CD4+ T cells into effector Th1 cells
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• exhibit impaired differentiation of precursor CD4+ T cells into effector T helper 1 cells but not T helper 2 cells
• even in the presence of IL-2, precursor CD4+ T cells fail to differentiate into Th1 cells that produce large amounts of the effector cytokine IFN-gamma
• IFN-gamma production is reduced in effector Th1 cells; impairment of IFN-gamma production in Th1 cells is caused by insufficient IL-12 stimulated differentiation of the precursor CD4+ T cells into effector Th1 cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• need to be euthanized at approximately 10 weeks of age due to urinary retention and paraphimosis
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• the articular cartilage thickness, the width of the joint at the level of the femoral condyles, and the height of the tibial plateau are decreased
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• enlargement of the growth plate
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• at 10 weeks of age
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• separation at the joints is not well defined at 10 weeks of age
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• ectopic ossification localized in the caudal thoracic and thoracic spine at 4 weeks of age
• the typical lamellar structure of the annulus fibrosus is completely absent at 4 weeks of age
• at 10 weeks of age in the proximal thoracic spine (approximately cranial to T9) disks are replaced by a proteoglycan-rich cartilaginous tissue that extends beyond the disk and appears to connect the distal and proximal growth plates of adjacent vertebral bodies
• at E15.5 and E17.5, the annulus fibrosus is populated by larger, chondrocyte-like cells with altered alignment of the collagen fibers in the laminae
• increased annulus fibrosus width for both dorsal and ventral regions at E17.5
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• reduced in size at 4 weeks of age
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• seen at P11
• at 10 weeks of age most of the area of the disks is completely replaced with bone and cartilage in the lumbar and caudal thoracic spine
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• ectopic ossification in multiple structures of the vertebrae including the transverse and spinous processes
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• decreased length at E17.5
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• fused vertebrae with no space where the intervertebral disks should be
• fusions in the transverse and spinous processes are seen at P11 with the most advanced lesions seen in the lumbar spine
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• seen at E17.5 along with abnormally shaped primary ossification centers
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• fusions of bodies and posterior elements are detected in the lumbar and thoracic spine
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• at weaning
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• at weaning
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• the articular cartilage thickness, the width of the joint at the level of the femoral condyles, and the height of the tibial plateau are decreased
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• upward tail orientation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| scoliosis | DOID:0060249 | J:277201 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following treatment with an andenoviral cre, mouse embryonic fibroblasts exhibit reduced UV- or TNF-stimulated apoptosis compared to wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• resistance to MPTP-induced Parkinson's disease
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• much improved neuron survival in the facial motor nucleus after axotomy (52% survive)
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| N |
• MPTP treatment had no effect on rotarod performance at any speed
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• resistance to MPTP-induced Parkinson's disease
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• somewhat reduced dopamine levels after MTP treatment
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• resistance to MPTP-induced Parkinson's disease
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mapk8tm1Flv/Mapk8tm1Flv Mapk9tm1Flv/Mapk9+ pups exhibit open eyes at birth
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• 80% die within 48 hours after birth
(J:83385)
• majority die within 48 hours after birth, although a small number survive to adulthood
(J:93433)
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• exhibit a number of developmental defects in the eye at E18.5
(J:83385)
• mutants that survive to adulthood have opaque eyes
(J:93433)
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• show severe lens abnormality at E18.5
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• smaller lenses with decreased expression of alpha-, beta-, and gamma-crystallin
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• show retinal coloboma at midgestation
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• eyelids exhibit variable extension across the cornea but no contact with the opposing epithelia
(J:93433)
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• exhibit immature lungs at P1
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• alveolar septae are thicker and more cellular at P1, indicating immaturity of lung development
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• appear to have difficulty breathing at birth
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• tongue epidermis shows a reduction in proliferation at E15.5
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• epithelium of tongue is immature at E18.5, with no fungiform taste papillae
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• exhibit no fungiform taste papillae at E18.5
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• pups exhibit immature intestines; intestines have all the differentiated cell types but show irregular loops and shorter villi
• delay in maturation of villi is apparent at E14.5, soon after the villi start to form
• defects in intestines are more severe in embryos than after birth
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• exhibit epithelial immaturity in the intestines
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• number of periodic acid/Schiff reagent-staining surface mucous cells is reduced
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• mutants that survive to adulthood are sterile
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• E18.5 kidneys have deformed renal epithelium
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• E18.5 kidneys have deformed nephrons
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• E18.5 kidneys contain enlarged tubules
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• tongue epidermis shows a reduction in proliferation at E15.5
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• epithelium of tongue is immature at E18.5, with no fungiform taste papillae
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• exhibit no fungiform taste papillae at E18.5
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• interfollicular epidermal proliferation is reduced in E15.5 skin
• E18.5 skin shows disorganized and immature development of the hair follicles
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• newborns exhibit fewer hair follicles
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• exhibit disorganized and immature development of the epidermis at E18.5
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• tongue epidermis shows a reduction in proliferation at E15.5
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• epithelium of tongue is immature at E18.5, with no fungiform taste papillae
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• exhibit no fungiform taste papillae at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• develop less atherosclerosis than single Apoe homozygotes when fed a high-cholesterol diet for 14 weeks
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• isolated macrophages form filopodia-like projections in culture that are not observed in controls
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• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls
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• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls
• uptake and degradation of acetylated forms of low-density lipoproteins by macrophages is about one third that of controls
• cellular cholesterol efflux to apolipoprotein AI is increased in macrophages
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• isolated macrophages form filopodia-like projections in culture that are not observed in controls
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• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls
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• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls
• uptake and degradation of acetylated forms of low-density lipoproteins by macrophages is about one third that of controls
• cellular cholesterol efflux to apolipoprotein AI is increased in macrophages
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• isolated peritoneal macrophages subjected to oxidized forms of low-density lipoproteins form only half as many foam cells as controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have significantly higher numbers of apoptotic cells in the ilea compared to lower numbers in the infiltrate indicating a higher rate of apoptosis
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| N |
• there is no change in CD4+ to CD8+ ratios compared to findings in Tnftm2Gkl/+ single mutants
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• there is a delayed onset and significant attenuation of disease
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• there is a delayed onset and significant attenuation of disease
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• do not exhibit exencephaly or show abnormal apoptosis during brain development
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between E11 and E12
• some mutants start to show embryonic degeneration that included decreased body size, transparency of embryos, and cardiac dilation at E11.5
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• show reduced apoptosis in the hindbrain neural tube during cephalic neurulation at E9
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• exhibit about 10-fold increase in apoptosis in the forebrain neural epithelium at E10.5
• E11 forebrain shows increased pyknosis
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• exhibit about 10-fold increase in apoptosis in the forebrain neural epithelium at E10.5
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• exhibit hindbrain exencephaly that is already visible at E10.5
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• cardiac dilation in degenerating embryos at E11.5
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• show reduced apoptosis in the hindbrain neural tube during cephalic neurulation at E9
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• exhibit about 10-fold increase in apoptosis in the forebrain neural epithelium at E10.5
• E11 forebrain shows increased pyknosis
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• exhibit about 10-fold increase in apoptosis in the forebrain neural epithelium at E10.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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