Mouse Genome Informatics
cn1
    Mapk1tm1.2Kuta/Mapk1tm1.2Kuta
Tg(Nes-cre)1Kag/0

involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• resident males show a shorter latency to attack and attack for a longer duration with a higher frequency
• spend more time in the center of an open field and spend more time in the open arms of a plus maze compared to controls
• fail to show a preference for a novel mouse
• decrease in interaction with a novel object compared to controls
• context freezing response is significantly reduced
• cued fear conditioning response is reduced after a 48 h retention delay
• pups are more scattered in the home cage (J:176051)
• show a significantly shorter duration of crouching to keep the pups warm and to nurse them (J:176051)
• show little nest building activity and build shallower nest compared to controls
• males display persistent interest when presented with the same female indicating a failure to develop social memory
• fail to show a preference for a novel mouse
• in an open field test for social versus inanimate preference, mice show no significant difference in time spent interacting with the social or inanimate targets unlike controls
• in a sociability test for social versus empty preference, mice show a significant decrease in interaction with the social target compared to controls

nervous system
• in the cortices at 13 weeks of age

taste/olfaction
N
• no defect in olfaction is detected (J:176051)

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:176051


Mouse Genome Informatics
cn2
    Abl1tm1Ajk/Abl1tm1Ajk
Abl2tm1Ajk/Abl2tm1Ajk
Tg(Nes-cre)1Kag/?

involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
N
• only 35% of the expected Mendelian numbers are born (J:99296)
• those that were born survived well into adulthood (J:99296)

nervous system
• smaller dendrite arbors resulting in more densely packed neurons in all layers of cortex in 6-8 weeks old mice


Mouse Genome Informatics
cn3
    Huwe1tm1Alas/Y
Tg(Nes-cre)1Kag/0

involves: 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging

nervous system
• in the germinal layers (J:152966)
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice (J:152966)
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice (J:152966)
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells (J:152966)
• brains contain ectopic cellular clusters in differentiated striatal regions unlike in wild-type mice (J:152966)
• however, no abnormalities are observed at E15.5 (J:152966)
• poorly developed (J:152966)
• the cortex exhibits an increase in cellular density and decrease in intervening neuropil compared to in wild-type mice (J:152966)
• laminar organization is altered with no clearly identifiable superficial neuron layers compared to in wild-type mice (J:152966)
• very small (J:152966)

cellular
• in the germinal layers (J:152966)
• at E13.5, E15.5, E18.5, fewer progenitors exit the cell cycle compared with wild-type mice (J:152966)
• at E18.5, proliferation of neuronal precursors is increased compared to in wild-type mice (J:152966)
• at E18.5, the length of the cycle is lengthened compared to in wild-type cells (J:152966)


Mouse Genome Informatics
cn4
    Dmrta2tm1.1Fuma/Dmrta2tm1.1Fuma
Tg(Nes-cre)1Kag/0

involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• mice exhibit normal formation of the cortical hem and the hippocampal primordium in the medial cortex (J:203109)
• moderate at E15.5
• however, size is normal at E12.5


Mouse Genome Informatics
cn5
    Spentm2.1Hon/Spentm2.1Hon
Tg(Nes-cre)1Kag/?

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• increased mortality before 10 weeks of age

growth/size
• although normal at birth, mice are growth retarded at 3 weeks of age

nervous system
• reduced in size
• severe reductions in the thickness of the cerebral cortex


Mouse Genome Informatics
cn6
    Sqstm1tm1.1Ewa/Sqstm1tm1.1Ewa
Tg(Nes-cre)1Kag/0

involves: C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• body weight gradually increases after 20 weeks of age, becoming significantly greater than littermate controls by 27 weeks of age

adipose tissue
• increase in visceral fat

behavior/neurological


Mouse Genome Informatics
cn7
    Hif1atm1Stom/Hif1atm1.1Stom
Tg(Nes-cre)1Kag/0

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• density of blood vessels is reduced
• in adults
• thinner than in controls at E19
• dense nuclei found with a wavy architecture
• apoptotic neural and glial cells detected
• atrophy of the cerebral cortex in adults
• significant reduction of neurons at 10 weeks of age although six layered structure of the cortex is maintained
• 36% reduction of neurons at 10 weeks of age
• 36% loss of neurons in the perirhinal cortex at 10 weeks of age
• 12% reduction of neurons on the dorsal side

behavior/neurological
N
• spontaneous activity is normal (J:85763)
• significantly impaired memory consolidation after 4 days of testing using a radial maze task


Mouse Genome Informatics
cn8
    Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
Tg(Nes-cre)1Kag/0

Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• born alive but do not survive beyond P10

nervous system
• increase in the number of astrocytes in the cortex at E18.5