All Phenotypes Emx1<tm1(cre)Yql> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Emx1^tm1(cre)Yql
targeted mutation 1, Yuqing Li
MGI:2176219

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Emx1^tm1(cre)Yql/Emx1^tm1(cre)Yql	involves: 129S2/SvPas * C57BL/6	MGI:2179804
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Emx1^tm1(cre)Yql/Emx1⁺	B6.129-Emx1^tm1(cre)Yql Ctnnb1^tm2Kem	MGI:3054987
cn3	Emx1^tm1(cre)Yql/Emx1⁺ Lhx2^tm1Monu/Lhx2^tm1Monu	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3772185
cn4	Arhgef9^tm1Betz/Y Emx1^tm1(cre)Yql/Emx1⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3820316
cn5	Fgf13^tm1Xuzh/Y Emx1^tm1(cre)Yql/Emx1⁺	involves: 129S2/SvPas	MGI:5433296
cn6	Emx1^tm1(cre)Yql/Emx1⁺ Tor1a^tm2Yql/Tor1a^tm2Yql	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:3772569
cn7	Btbd9^{tm1c(EUCOMM)Wtsi}/Btbd9^{tm1c(EUCOMM)Wtsi} Emx1^tm1(cre)Yql/Emx1⁺	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N	MGI:6488233
cn8	Cdyl^tm1.1Yuw/Cdyl^tm1.1Yuw Emx1^tm1(cre)Yql/Emx1⁺	involves: 129S2/SvPas * C57BL/6	MGI:6121112

Allelic Composition	Emx1^tm1(cre)Yql/Emx1^tm1(cre)Yql
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent corpus callosum ( J:64802 )

• Background Sensitivity: the absence of a corpus collosum was noted on a segregating 129/Sv x C57BL/6 genetic background; however, no such phenotype was reported when the mutation was made congenic on a C57BL/6 background

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Emx1^tm1(cre)Yql/Emx1⁺
Genetic Background	B6.129-Emx1^tm1(cre)Yql Ctnnb1^tm2Kem

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nursing ( J:92923 )

• females display poor nursing behavior

• 80% do not nurse at all and abandon pups

seizures ( J:92923 )

• seizures can be induced by handling in 4 month old animals

increased susceptibility to pharmacologically induced seizures ( J:92923 )

• significantly higher numbers of phase I and phase II seizures

• duration of seizures increased for phase I

• 2X as much time in seizure as controls

• increased sensitivity to PTZ induced seizures

• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls

growth/size/body

decreased body size ( J:92923 )

• males significantly smaller than littermates

reproductive system

male infertility ( J:92923 )

nervous system

seizures ( J:92923 )

• seizures can be induced by handling in 4 month old animals

increased susceptibility to pharmacologically induced seizures ( J:92923 )

• increased sensitivity to PTZ induced seizures

• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls

• significantly higher numbers of phase I and phase II seizures

• duration of seizures increased for phase I

• 2X as much time in seizure as controls

dilated lateral ventricle ( J:92923 )

• as a result of missing hippocampal structures

absent corpus callosum ( J:92923 )

absent hippocampal commissure ( J:92923 )

• lack hippocampal commissure

abnormal hippocampus morphology ( J:92923 )

• CA1, CA2, CA3 all not detected

absent hippocampus CA1 region ( J:92923 )

absent hippocampus CA2 region ( J:92923 )

absent hippocampus CA3 region ( J:92923 )

absent dentate gyrus ( J:92923 )

abnormal cerebral cortex morphology ( J:92923 )

• impaired cortical development, failure of lobes to extend caudally

• adult brain similar in appearance to perinatal brain

• thinner cortex

Allelic Composition	Emx1^tm1(cre)Yql/Emx1⁺ Lhx2^tm1Monu/Lhx2^tm1Monu
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Lhx2^tm1Monu mutation (0 available); any Lhx2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:130167 )

• mice exhibit subtle to inapparent abnormalities in the cortical hem at E12.5

Allelic Composition	Arhgef9^tm1Betz/Y Emx1^tm1(cre)Yql/Emx1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef9^tm1Betz mutation (0 available); any Arhgef9 mutation (6 available)
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:141850 )

• strong reduction in gephyrin cluster numbers in the hippocampus at P40, P60 and P130

• however, clustering is unaffected in other areas of the brain

Allelic Composition	Fgf13^tm1Xuzh/Y Emx1^tm1(cre)Yql/Emx1⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Fgf13^tm1Xuzh mutation (0 available); any Fgf13 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:186253 )

abnormal object recognition memory ( J:186253 )

• impaired

abnormal spatial learning ( J:186253 )

• in a Morris water maze

abnormal spatial working memory ( J:186253 )

• in a Morris water maze

abnormal depression-related behavior ( J:186253 )

• increased depression-like behavior

behavioral despair ( J:186253 )

increased anxiety-related response ( J:186253 )

• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice

hyperactivity ( J:186253 )

• slight

nervous system

abnormal cerebral cortex pyramidal cell morphology ( J:186253 )

• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice

abnormal axon morphology ( J:186253 )

• most cultured cortical neurons remain multipolar shape unlike control neurons

• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice

Allelic Composition	Emx1^tm1(cre)Yql/Emx1⁺ Tor1a^tm2Yql/Tor1a^tm2Yql
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)
Tor1a^tm2Yql mutation (0 available); any Tor1a mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:130483 )

• on a beam-walking test, 71% of mice exhibit more falls than wild-type mice

• however, mice perform normally in a rotarod test

abnormal gait ( J:130483 )

• the hind base of male mice is smaller than in wild-type mice

hyperactivity ( J:130483 )

• mice exhibit hyperactivity in an open-field test

circling ( J:130483 )

increased stereotypic behavior ( J:130483 )

nervous system

nervous system phenotype ( J:130483 )

N	• the cerebral cortex and dopamine metabolite levels are normal

Allelic Composition	Btbd9^{tm1c(EUCOMM)Wtsi}/Btbd9^{tm1c(EUCOMM)Wtsi} Emx1^tm1(cre)Yql/Emx1⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Cell Lines	EPD0631_3_A09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Btbd9 mutation (50 available)
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:282582 )

• mice exhibit a 219% increase of slips in the beam walking test

• however, mice do not show a deficit in the rotarod test

hyperactivity ( J:282582 )

• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness

• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls

abnormal sleep behavior ( J:282582 )

• sleep analysis indicates an increased probability of waking in the light phase but not dark phase

increased thermal nociceptive threshold ( J:282582 )

• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception

nervous system

abnormal primary motor cortex morphology ( J:282582 )

• mice exhibit thinner cortical layers in the posterior primary motor cortex

abnormal primary somatosensory cortex morphology ( J:282582 )

• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
restless legs syndrome		DOID:0050425	OMIM:PS102300	J:282582

Allelic Composition	Cdyl^tm1.1Yuw/Cdyl^tm1.1Yuw Emx1^tm1(cre)Yql/Emx1⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdyl^tm1.1Yuw mutation (0 available); any Cdyl mutation (70 available)
Emx1^tm1(cre)Yql mutation (0 available); any Emx1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:251551 )

N	• behavior in Morris water maze, elevated plus maze, open field and context-dependent and cue-dependent fear conditioning tests • locomotor behavior in Morris water maze, elevated plus maze and open field tests

increased susceptibility to pharmacologically induced seizures ( J:251551 )

• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

cellular

abnormal neuronal migration ( J:251551 )

• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2

nervous system

increased susceptibility to pharmacologically induced seizures ( J:251551 )

• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

abnormal neuronal migration ( J:251551 )

• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
epilepsy		DOID:1826		J:251551

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