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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Emx1tm1(cre)Yql
targeted mutation 1, Yuqing Li
MGI:2176219
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Emx1tm1(cre)Yql/Emx1tm1(cre)Yql involves: 129S2/SvPas * C57BL/6 MGI:2179804
cn2
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Emx1tm1(cre)Yql/Emx1+
B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem MGI:3054987
cn3
Emx1tm1(cre)Yql/Emx1+
Lhx2tm1Monu/Lhx2tm1Monu
involves: 129P2/OlaHsd * 129S2/SvPas MGI:3772185
cn4
Arhgef9tm1Betz/Y
Emx1tm1(cre)Yql/Emx1+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3820316
cn5
Fgf13tm1Xuzh/Y
Emx1tm1(cre)Yql/Emx1+
involves: 129S2/SvPas MGI:5433296
cn6
Emx1tm1(cre)Yql/Emx1+
Tor1atm2Yql/Tor1atm2Yql
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3772569
cn7
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Emx1tm1(cre)Yql/Emx1+
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N MGI:6488233
cn8
Cdyltm1.1Yuw/Cdyltm1.1Yuw
Emx1tm1(cre)Yql/Emx1+
involves: 129S2/SvPas * C57BL/6 MGI:6121112


Genotype
MGI:2179804
hm1
Allelic
Composition
Emx1tm1(cre)Yql/Emx1tm1(cre)Yql
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Background Sensitivity: the absence of a corpus collosum was noted on a segregating 129/Sv x C57BL/6 genetic background; however, no such phenotype was reported when the mutation was made congenic on a C57BL/6 background




Genotype
MGI:3054987
cn2
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (41 available)
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• females display poor nursing behavior
• 80% do not nurse at all and abandon pups
• seizures can be induced by handling in 4 month old animals
• increased sensitivity to PTZ induced seizures
• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls
• significantly higher numbers of phase I and phase II seizures
• duration of seizures increased for phase I
• 2X as much time in seizure as controls

growth/size/body
• males significantly smaller than littermates

reproductive system

nervous system
• seizures can be induced by handling in 4 month old animals
• increased sensitivity to PTZ induced seizures
• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls
• significantly higher numbers of phase I and phase II seizures
• duration of seizures increased for phase I
• 2X as much time in seizure as controls
• as a result of missing hippocampal structures
• lack hippocampal commissure
• CA1, CA2, CA3 all not detected
• impaired cortical development, failure of lobes to extend caudally
• adult brain similar in appearance to perinatal brain
• thinner cortex




Genotype
MGI:3772185
cn3
Allelic
Composition
Emx1tm1(cre)Yql/Emx1+
Lhx2tm1Monu/Lhx2tm1Monu
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
Lhx2tm1Monu mutation (0 available); any Lhx2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit subtle to inapparent abnormalities in the cortical hem at E12.5




Genotype
MGI:3820316
cn4
Allelic
Composition
Arhgef9tm1Betz/Y
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef9tm1Betz mutation (0 available); any Arhgef9 mutation (6 available)
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• strong reduction in gephyrin cluster numbers in the hippocampus at P40, P60 and P130
• however, clustering is unaffected in other areas of the brain




Genotype
MGI:5433296
cn5
Allelic
Composition
Fgf13tm1Xuzh/Y
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
Fgf13tm1Xuzh mutation (0 available); any Fgf13 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in a Morris water maze
• in a Morris water maze
• increased depression-like behavior
• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice
• slight

nervous system
• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
• most cultured cortical neurons remain multipolar shape unlike control neurons
• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice




Genotype
MGI:3772569
cn6
Allelic
Composition
Emx1tm1(cre)Yql/Emx1+
Tor1atm2Yql/Tor1atm2Yql
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
Tor1atm2Yql mutation (0 available); any Tor1a mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• on a beam-walking test, 71% of mice exhibit more falls than wild-type mice
• however, mice perform normally in a rotarod test
• the hind base of male mice is smaller than in wild-type mice
• mice exhibit hyperactivity in an open-field test

nervous system
N
• the cerebral cortex and dopamine metabolite levels are normal




Genotype
MGI:6488233
cn7
Allelic
Composition
Btbd9tm1c(EUCOMM)Wtsi/Btbd9tm1c(EUCOMM)Wtsi
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6N
Cell Lines EPD0631_3_A09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btbd9tm1c(EUCOMM)Wtsi mutation (0 available); any Btbd9 mutation (40 available)
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a 219% increase of slips in the beam walking test
• however, mice do not show a deficit in the rotarod test
• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness
• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls
• sleep analysis indicates an increased probability of waking in the light phase but not dark phase
• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception

nervous system
• mice exhibit thinner cortical layers in the posterior primary motor cortex
• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
restless legs syndrome DOID:0050425 OMIM:PS102300
J:282582




Genotype
MGI:6121112
cn8
Allelic
Composition
Cdyltm1.1Yuw/Cdyltm1.1Yuw
Emx1tm1(cre)Yql/Emx1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdyltm1.1Yuw mutation (0 available); any Cdyl mutation (58 available)
Emx1tm1(cre)Yql mutation (0 available); any Emx1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• behavior in Morris water maze, elevated plus maze, open field and context-dependent and cue-dependent fear conditioning tests
• locomotor behavior in Morris water maze, elevated plus maze and open field tests
• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures

cellular
• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2

nervous system
• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:251551





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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory