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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prm-cre)58Og
transgene insertion 58, Stephen O'Gorman
MGI:2176182
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Pth2tm1Vlcg/Pth2tm1Vlcg
Tg(CAG-LacZ,-Pth2)1Tbu/0
Tg(Prm-cre)58Og/0
involves: 129 * C57BL/6 MGI:3808008
cn2
Ezh2tm1Sho/Ezh2tm1Sho
Tg(Prm-cre)58Og/?
involves: 129 * C57BL/6J MGI:3805324
cn3
Ogttm1Gwh/Ogt+
Tg(Prm-cre)58Og/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3841629
cn4
Casktm1Sud/Casktm1.1Sud
Tg(Prm-cre)58Og/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3699502
cn5
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Prm-cre)58Og/0
involves: 129S1/SvImJ * 129S4/SvJae MGI:6852583
cn6
Krastm4Tyj/Kras+
Tg(Prm-cre)58Og/0
involves: 129S4/SvJae MGI:3716392
cn7
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Prm-cre)58Og/0
involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6 MGI:6491904
cn8
Inpp5btm2Nbm/Inpp5btm2Nbm
Tg(Prm-cre)58Og/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6 MGI:3040923
cn9
Snx20tm1Lex/Snx20tm1Lex
Tg(Prm-cre)58Og/0
involves: 129S/SvEvBrd * 129S4/SvJae MGI:3774652


Genotype
MGI:3808008
cn1
Allelic
Composition
Pth2tm1Vlcg/Pth2tm1Vlcg
Tg(CAG-LacZ,-Pth2)1Tbu/0
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2tm1Vlcg mutation (0 available); any Pth2 mutation (4 available)
Tg(CAG-LacZ,-Pth2)1Tbu mutation (0 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• male fertility is restored
• persists




Genotype
MGI:3805324
cn2
Allelic
Composition
Ezh2tm1Sho/Ezh2tm1Sho
Tg(Prm-cre)58Og/?
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Sho mutation (0 available); any Ezh2 mutation (54 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:3841629
cn3
Allelic
Composition
Ogttm1Gwh/Ogt+
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ogttm1Gwh mutation (2 available); any Ogt mutation (12 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile with no gross abnormalities and expression levels of Ogt that are similar to controls suggesting inactivation of the paternal X chromosome in all tissues and cell types surveyed
• mice do not produce any offspring carrying the recombined allele




Genotype
MGI:3699502
cn4
Allelic
Composition
Casktm1Sud/Casktm1.1Sud
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casktm1.1Sud mutation (0 available); any Cask mutation (13 available)
Casktm1Sud mutation (1 available); any Cask mutation (13 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cleft palate in Casktm1Sud/Casktm1.1Sud Tg(Prm-cre)580g/0 mice

mortality/aging
• die within a few hours of birth

craniofacial
• observed in homozygotes with ~80% penetrance

digestive/alimentary system
• observed in homozygotes with ~80% penetrance

nervous system
N
• synapse formation and membrane properties of cultured neurons are not significantly different from wild-type neurons; vesicle pool sizes and evoked neurotransmitter release are similar in mutant and wild-type neurons
• number of apoptotic neurons in thalamus is increased 3-fold compared to controls
• excitatory spontaneous mini events show 2-fold increase in frequency in cultured neurons, while inhibitory minifrequency is decreased ~1.4 fold

respiratory system
• plethysmography of newborns shows severe postnatal respiratory failure

cellular
• number of apoptotic neurons in thalamus is increased 3-fold compared to controls

growth/size/body
• observed in homozygotes with ~80% penetrance




Genotype
MGI:6852583
cn5
Allelic
Composition
Meig1tm1.1Zzha/Meig1tm1.1Zzha
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S1/SvImJ * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation (0 available); any Meig1 mutation (10 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• all males are fertile and sire normal numbers of offspring
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• epididymidal sperm count, testis as well as epididymal histology and sperm morphology are normal, and no reduction in sperm motility is observed




Genotype
MGI:3716392
cn6
Allelic
Composition
Krastm4Tyj/Kras+
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (55 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E9.5 vasculature is poorly developed; vasculature has a primitive honeycomb-like network lacking branching vitelline vessels, while large vitelline vessels are absent
• at death, embryos exhibit widespread apoptosis
• embryos show developmental arrest
• marked defect in inner labyrinth layer is observed at E9.5
• fetal blood vessels underlying inner labyrinth layer are absent
• at E9.5, yolk sacs are pale and roughened

cellular
• at death, embryos exhibit widespread apoptosis

cardiovascular system
• fetal blood vessels underlying inner labyrinth layer are absent
• at E9.5 vasculature is poorly developed; vasculature has a primitive honeycomb-like network lacking branching vitelline vessels, while large vitelline vessels are absent




Genotype
MGI:6491904
cn7
Allelic
Composition
Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1.1Jhha mutation (0 available); any Mettl3 mutation (34 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• normal male fertility and seminiferous tubules morphology




Genotype
MGI:3040923
cn8
Allelic
Composition
Inpp5btm2Nbm/Inpp5btm2Nbm
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5btm2Nbm mutation (1 available); any Inpp5b mutation (46 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mutant males display normal fertility with normal litter sizes




Genotype
MGI:3774652
cn9
Allelic
Composition
Snx20tm1Lex/Snx20tm1Lex
Tg(Prm-cre)58Og/0
Genetic
Background
involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx20tm1Lex mutation (1 available); any Snx20 mutation (7 available)
Tg(Prm-cre)58Og mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are overall normal and healthy

immune system
N
• mice exhibit normal neutrophil morphology and physiology





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory