Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth2tm1Vlcg mutation
(0 available);
any
Pth2 mutation
(4 available)
Tg(CAG-LacZ,-Pth2)1Tbu mutation
(0 available)
Tg(Prm-cre)58Og mutation
(4 available)
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reproductive system
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N |
• male fertility is restored
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normal phenotype
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• mice are viable and fertile with no gross abnormalities and expression levels of Ogt that are similar to controls suggesting inactivation of the paternal X chromosome in all tissues and cell types surveyed
• mice do not produce any offspring carrying the recombined allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casktm1.1Sud mutation
(0 available);
any
Cask mutation
(14 available)
Casktm1Sud mutation
(1 available);
any
Cask mutation
(14 available)
Tg(Prm-cre)58Og mutation
(4 available)
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Cleft palate in Casktm1Sud/Casktm1.1Sud Tg(Prm-cre)580g/0 mice
mortality/aging
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• die within a few hours of birth
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craniofacial
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• observed in homozygotes with ~80% penetrance
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digestive/alimentary system
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• observed in homozygotes with ~80% penetrance
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nervous system
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N |
• synapse formation and membrane properties of cultured neurons are not significantly different from wild-type neurons; vesicle pool sizes and evoked neurotransmitter release are similar in mutant and wild-type neurons
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• number of apoptotic neurons in thalamus is increased 3-fold compared to controls
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• excitatory spontaneous mini events show 2-fold increase in frequency in cultured neurons, while inhibitory minifrequency is decreased ~1.4 fold
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respiratory system
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• plethysmography of newborns shows severe postnatal respiratory failure
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cellular
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• number of apoptotic neurons in thalamus is increased 3-fold compared to controls
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growth/size/body
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• observed in homozygotes with ~80% penetrance
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meig1tm1.1Zzha mutation
(0 available);
any
Meig1 mutation
(14 available)
Tg(Prm-cre)58Og mutation
(4 available)
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reproductive system
 N |
• all males are fertile and sire normal numbers of offspring
• testis weight to body weight and seminal vesicle weight to body weight ratios are normal
• epididymidal sperm count, testis as well as epididymal histology and sperm morphology are normal, and no reduction in sperm motility is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyco1tm1.1Arte mutation
(0 available);
any
Fyco1 mutation
(44 available)
Tg(Prm-cre)58Og mutation
(4 available)
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vision/eye
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• at P60, lens epithelial cells show extensive vacuolization
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• at P60, lens fiber cells are large and display irregular shapes
• at P0, P7, and P14, differentiating lens fiber cells show abnormal retention of cellular organelles, including endoplasmic reticulum (ER), mitochondria, and Golgi apparatus (GA), suggesting impaired organelle removal
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• mice show initial signs of lens opacities at 4 weeks that develop into mild cataracts at ~8 weeks of age
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• mice develop mature bilateral cataracts by 16 weeks of age; extent of lens opacities is variable among mice
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cellular
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• at P14, lenses show an increased Golgi apparatus mass relative to age-matched wild-type lenses
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• at P0, P7, P14 and P21, lenses show an increased ER mass relative to age-matched wild-type lenses
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• at P0, lenses show alterations in many autophagy-associated genes, proteins and lipids, including a 1.48-fold increase in the level of SQSTM1/p62 and a modest accumulation of phosphatidylethanolamine (PE) phospholipids, suggesting impaired autophagy
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Tg(Prm-cre)58Og mutation
(4 available)
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mortality/aging
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• mutants die between E9.5 and 11.5
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embryo
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• at E9.5 vasculature is poorly developed; vasculature has a primitive honeycomb-like network lacking branching vitelline vessels, while large vitelline vessels are absent
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• at death, embryos exhibit widespread apoptosis
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• embryos show developmental arrest
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• marked defect in inner labyrinth layer is observed at E9.5
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• fetal blood vessels underlying inner labyrinth layer are absent
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• at E9.5, yolk sacs are pale and roughened
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cellular
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• at death, embryos exhibit widespread apoptosis
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cardiovascular system
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• fetal blood vessels underlying inner labyrinth layer are absent
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• at E9.5 vasculature is poorly developed; vasculature has a primitive honeycomb-like network lacking branching vitelline vessels, while large vitelline vessels are absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1.1Jhha mutation
(0 available);
any
Mettl3 mutation
(39 available)
Tg(Prm-cre)58Og mutation
(4 available)
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reproductive system
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N |
• normal male fertility and seminiferous tubules morphology
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Huwe1tm1Alas mutation
(0 available);
any
Huwe1 mutation
(63 available)
Tg(Prm-cre)58Og mutation
(4 available)
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reproductive system
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N |
• male mice are fertile and show normal spermatogenesis with no significant differences in sperm number, sperm motility or testis weights relative to control males
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5btm2Nbm mutation
(1 available);
any
Inpp5b mutation
(57 available)
Tg(Prm-cre)58Og mutation
(4 available)
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reproductive system
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N |
• mutant males display normal fertility with normal litter sizes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyco1tm1.1Arte mutation
(0 available);
any
Fyco1 mutation
(44 available)
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill mutation
(1 available)
Tg(Prm-cre)58Og mutation
(4 available)
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cellular
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• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snx20tm1Lex mutation
(1 available);
any
Snx20 mutation
(12 available)
Tg(Prm-cre)58Og mutation
(4 available)
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normal phenotype
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• mice are overall normal and healthy
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immune system
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N |
• mice exhibit normal neutrophil morphology and physiology
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Analysis Tools
