All Phenotypes Tg(Wap-cre)11738Mam MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Wap-cre)11738Mam
transgene insertion 11738, Lothar Hennighausen
MGI:2176167

Summary

39 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Wap-cre)11738Mam/0	FVB.Cg-Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam	MGI:5576521
cn2	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Wap-cre)11738Mam/0 Tg(Wap-Hgf)402Mig/0	FVB.Cg-Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig	MGI:5576520
cn3	Ctnnb1^tm1Mmt/Ctnnb1⁺ Cxcr4^tm2Yzo/Cxcr4^tm2Yzo Tg(Wap-cre)11738Mam/0 Tg(Wap-Hgf)402Mig/0	FVB.Cg-Cxcr4^tm2Yzo Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig	MGI:5576532
cn4	n-TUtca2^tm1Dhat/n-TUtca2^tm1Dhat Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6	MGI:2655310
cn5	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6J * C57BL/6NCr	MGI:3709976
cn6	Gt(ROSA)26Sor^tm1(Myc)Rcse/Gt(ROSA)26Sor^tm1(Myc)Rcse Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6 * SJL	MGI:4941159
cn7	Gt(ROSA)26Sor^{tm3(mycS62A)Rcse}/Gt(ROSA)26Sor^{tm3(mycS62A)Rcse} Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6 * SJL	MGI:4941161
cn8	Gt(ROSA)26Sor^{tm2(mycT58A)Rcse}/Gt(ROSA)26Sor^{tm2(mycT58A)Rcse} Tg(Wap-cre)11738Mam/0	involves: 129 * C57BL/6 * SJL	MGI:4941160
cn9	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53⁺ Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834737
cn10	Brca1^tm2Mak/Brca1^tm2Mak Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834735
cn11	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53^tm1Brd Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834738
cn12	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834736
cn13	Pten^tm2Mak/Pten^tm2Mak Trp53^tm1Brn/Trp53^tm1Brn Tg(Wap-cre)11738Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5752196
cn14	Pten^tm2Mak/Pten^tm2Mak Tg(Wap-cre)11738Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5752190
cn15	Esr1^tm1Sakh/Esr1^tm1Sakh Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:4459317
cn16	Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2680269
cn17	Tsg101^tm1Kuw/Tsg101^tm1Kuw Tg(Wap-cre)11738Mam/0 Tg(Wap-Tsg101)4389Kuw/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL	MGI:3710382
cn18	Phb2^tm2.1Katz/Phb2⁺ Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5299192
cn19	Tsg101^tm1Kuw/Tsg101^tm1Kuw Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3710383
cn20	Etv6^{tm3(NTRK3)Sho}/Etv6⁺ Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3772798
cn21	Trp53^tm3Tyj/Trp53⁺ Tg(Wap-cre)11738Mam/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5759821
cn22	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * Black Swiss	MGI:3055367
cn23	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * Black Swiss	MGI:3055364
cn24	Brca1^tm1Cxd/Brca1^tm2Cxd Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * Black Swiss	MGI:2176784
cn25	Bin1^tm1Gcp/Bin1^tm2Gcp Tg(MMTV-Myc)141-3Led/0 Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL	MGI:3697474
cn26	Bin1^tm1Gcp/Bin1^tm2Gcp Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:3793422
cn27	Bin1^tm2Gcp/Bin1⁺ Tg(Wap-cre)11738Mam/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:3793426
cn28	Stat1^tm1Mam/Stat1^tm1Mam Tg(Wap-cre)11738Mam/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:4942395
cn29	Jak2^tm1Kuw/Jak2^tm1Kuw Tg(Wap-cre)11738Mam/0	involves: 129X1/SvJ * C57BL/6 * FVB	MGI:3045814
cn30	Arnt^tm1Gonz/Arnt^tm1Gonz Tg(Wap-cre)11738Mam/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3656141
cn31	Ctnna1^tm1Efu/Ctnna1^tm1Efu Tg(Wap-cre)11738Mam/?	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3720651
cn32	Pparg^tm1Gonz/Pparg^tm1Gonz Tg(Wap-cre)11738Mam/?	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3722296
cn33	Jak1^tm1Kuw/Jak1^tm1Kuw Tg(Wap-cre)11738Mam/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:5796283
cn34	Nit1^tm1Hbn/Nit1^tm1Hbn Tg(Wap-cre)11738Mam/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3691220
cn35	Chek1^tm1Jmr/Chek1⁺ Tg(Wap-cre)11738Mam/0	involves: C57BL/6	MGI:3046697
cn36	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Wap-cre)11738Mam/0	involves: C57BL/6	MGI:3046696
cn37	Phb2^tm2.1Katz/Phb2^tm2.1Katz Tg(Wap-cre)11738Mam/0	involves: C57BL/6 * SJL	MGI:5299194
cn38	Tsg101^tm1Kuw/Tsg101^tm1Kuw Tg(Wap-cre)11738Mam/0	Not Specified	MGI:2447785
cn39	Il6st^tm1Mam/Il6st^tm1Mam Tg(Wap-cre)11738Mam/0	Not Specified	MGI:3511928

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Wap-cre)11738Mam/0
Genetic Background	FVB.Cg-Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence in breeding females ( J:206839 )

• the majority of females develop mammary gland tumors between 25 and 40 weeks postpartum

• tumors are squamous metaplasia

endocrine/exocrine glands

increased mammary gland tumor incidence in breeding females ( J:206839 )

• the majority of females develop mammary gland tumors between 25 and 40 weeks postpartum

• tumors are squamous metaplasia

integument

increased mammary gland tumor incidence in breeding females ( J:206839 )

• the majority of females develop mammary gland tumors between 25 and 40 weeks postpartum

• tumors are squamous metaplasia

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Tg(Wap-cre)11738Mam/0 Tg(Wap-Hgf)402Mig/0
Genetic Background	FVB.Cg-Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Hgf)402Mig mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence in breeding females ( J:206839 )

• tumor onset is more rapid than in either single mutant, with almost all females showing mammary gland tumors by 2 weeks postpartum

• tumors exhibit a mixed phenotype, with areas resembling basaloid hyperplasia and squamous metaplasia

• tumors exhibit morphological, gene and protein expression profile characteristics of basal breast cancers; they are HER2/ErbB2, ER, and PR negative, and express metastasis-associated genes

• treatment with the Wnt and Met inhibitors ICG-001 or PHA 665752 results in a moderate decrease in mammary gland tumor volume, treatment with a combination of these or with a small molecule inhibitor AMD3100, an agonist of CXCR4 receptor, strongly suppresses tumor onset up to 16 days, and treatment with all three shows the strongest inhibition in tumor size

increased mammary gland tumor incidence in virgin females ( J:206839 )

• in a few cases, virgin females develop small tumors

endocrine/exocrine glands

abnormal mammary gland morphology ( J:206839 )

• mammary gland tissues of breeding females show an expansion of CD24+/CD29(medium) and CD24+/CD49(hi) cells and depletion of CD24(low)/CD29+ cells, indicating expansion of a population of cells with progenitor and stem cell characteristics

abnormal mammary gland growth during lactation ( J:206839 )

• production of milk protein beta-casein after pregnancy is not detected indicating a block in normal mammary gland differentiation

mammary gland alveolar hyperplasia ( J:206839 )

• lobuloalveolar hyperplasia

increased mammary gland tumor incidence in breeding females ( J:206839 )

• tumor onset is more rapid than in either single mutant, with almost all females showing mammary gland tumors by 2 weeks postpartum

• tumors exhibit a mixed phenotype, with areas resembling basaloid hyperplasia and squamous metaplasia

• tumors exhibit morphological, gene and protein expression profile characteristics of basal breast cancers; they are HER2/ErbB2, ER, and PR negative, and express metastasis-associated genes

increased mammary gland tumor incidence in virgin females ( J:206839 )

• in a few cases, virgin females develop small tumors

integument

abnormal mammary gland morphology ( J:206839 )

abnormal mammary gland growth during lactation ( J:206839 )

• production of milk protein beta-casein after pregnancy is not detected indicating a block in normal mammary gland differentiation

mammary gland alveolar hyperplasia ( J:206839 )

• lobuloalveolar hyperplasia

increased mammary gland tumor incidence in breeding females ( J:206839 )

• tumor onset is more rapid than in either single mutant, with almost all females showing mammary gland tumors by 2 weeks postpartum

• tumors exhibit a mixed phenotype, with areas resembling basaloid hyperplasia and squamous metaplasia

• tumors exhibit morphological, gene and protein expression profile characteristics of basal breast cancers; they are HER2/ErbB2, ER, and PR negative, and express metastasis-associated genes

increased mammary gland tumor incidence in virgin females ( J:206839 )

• in a few cases, virgin females develop small tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:206839

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Cxcr4^tm2Yzo/Cxcr4^tm2Yzo Tg(Wap-cre)11738Mam/0 Tg(Wap-Hgf)402Mig/0
Genetic Background	FVB.Cg-Cxcr4^tm2Yzo Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Cxcr4^tm2Yzo mutation (1 available); any Cxcr4 mutation (40 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Hgf)402Mig mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence in breeding females ( J:206839 )

• appearance of mammary tumors in postpartum females is delayed compared to triple Ctnnb1^tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig mutants, with tumors developing at 7 weeks postpartum rather than 2 weeks

• tumors are smaller in females 2 weeks postpartum than in triple mutants

endocrine/exocrine glands

decreased mammary gland tumor incidence in breeding females ( J:206839 )

• tumors are smaller in females 2 weeks postpartum than in triple mutants

integument

decreased mammary gland tumor incidence in breeding females ( J:206839 )

• tumors are smaller in females 2 weeks postpartum than in triple mutants

Allelic Composition	n-TUtca2^tm1Dhat/n-TUtca2^tm1Dhat Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TUtca2^tm1Dhat mutation (0 available); any n-TUtca2 mutation (2 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:82321 )

N	• normal mammary development and normal lactation

Allelic Composition	Zfpm2^tm1Sho/Zfpm2^tm2Sho Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129 * C57BL/6J * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Zfpm2^tm1Sho mutation (2 available); any Zfpm2 mutation (47 available)
Zfpm2^tm2Sho mutation (1 available); any Zfpm2 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:120985 )

N	• mice are fertile

endocrine/exocrine glands

abnormal mammary gland morphology ( J:120985 )

• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded

• however, after 6 days of involution there is no difference when compared to controls

abnormal involution of the mammary gland ( J:120985 )

• involution occurs faster at days 3 and 4 of involution than in controls

integument

abnormal mammary gland morphology ( J:120985 )

• at day 4 of involution, alveoli are completely collapsed into clusters of epithelial cells and the area containing adipocytes is greatly expanded

• however, after 6 days of involution there is no difference when compared to controls

abnormal involution of the mammary gland ( J:120985 )

• involution occurs faster at days 3 and 4 of involution than in controls

Allelic Composition	Gt(ROSA)26Sor^tm1(Myc)Rcse/Gt(ROSA)26Sor^tm1(Myc)Rcse Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(Myc)Rcse mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal chromosome number ( J:169403 )

• 5 of 20 mammary epithelial cells exhibit abnormal karyotype compared with 2 of 20 control cells

chromosomal instability ( J:169403 )

• 5 of 20 mammary epithelial cells exhibit abnormal karyotype compared with 2 of 20 control cells

neoplasm

neoplasm ( J:169403 )

N	• mice do not develop tumors

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:169403 )

• mammary ductal branching is increased compared to in control mice

abnormal mammary gland epithelium physiology ( J:169403 )

• apoptosis of mammary gland epithelium during involution is increased compared to in control mice

increased mammary gland apoptosis ( J:169403 )

• apoptosis of mammary gland epithelium during involution is increased compared to in control mice

integument

abnormal branching of the mammary ductal tree ( J:169403 )

• mammary ductal branching is increased compared to in control mice

abnormal mammary gland epithelium physiology ( J:169403 )

• apoptosis of mammary gland epithelium during involution is increased compared to in control mice

increased mammary gland apoptosis ( J:169403 )

• apoptosis of mammary gland epithelium during involution is increased compared to in control mice

Allelic Composition	Gt(ROSA)26Sor^{tm3(mycS62A)Rcse}/Gt(ROSA)26Sor^{tm3(mycS62A)Rcse} Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(myc*S62A)Rcse} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

aneuploidy ( J:169403 )

• in mammary epithelial cells

polyploidy ( J:169403 )

• in mammary epithelial cells

chromosomal instability ( J:169403 )

• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

neoplasm

increased brain tumor incidence ( J:169403 )

• all mice succumb to brain tumors with a latency of 54 weeks

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:169403 )

• mammary ductal branching is decreased compared to in control mice

abnormal mammary gland alveolus morphology ( J:169403 )

• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sor^tm1(myc)Rcse/Gt(ROSA)26Sor^tm1(myc)Rcse Tg(Wap-cre)11738Mam mice

integument

abnormal branching of the mammary ductal tree ( J:169403 )

• mammary ductal branching is decreased compared to in control mice

abnormal mammary gland alveolus morphology ( J:169403 )

• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sor^tm1(myc)Rcse/Gt(ROSA)26Sor^tm1(myc)Rcse Tg(Wap-cre)11738Mam mice

nervous system

increased brain tumor incidence ( J:169403 )

• all mice succumb to brain tumors with a latency of 54 weeks

Allelic Composition	Gt(ROSA)26Sor^{tm2(mycT58A)Rcse}/Gt(ROSA)26Sor^{tm2(mycT58A)Rcse} Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(myc*T58A)Rcse} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased pituitary gland tumor incidence ( J:169403 )

increased brain tumor incidence ( J:169403 )

• 24 of 28 mice succumb to brain tumors (pituitary tumors and choroid plexus tumors) with a latency of 46 weeks

mortality/aging

decreased tumor-free survival time ( J:169403 )

• 24 of 28 mice succumb to brain tumors with a median survival of 46 weeks

neoplasm

increased mammary adenocarcinoma incidence ( J:169403 )

• 4 of 28 mice develop mammary tumors with a latency of 38 weeks

increased pituitary gland tumor incidence ( J:169403 )

increased brain tumor incidence ( J:169403 )

• 24 of 28 mice succumb to brain tumors (pituitary tumors and choroid plexus tumors) with a latency of 46 weeks

cellular

aneuploidy ( J:169403 )

• in mammary epithelial cells

polyploidy ( J:169403 )

• in mammary epithelial cells

chromosomal instability ( J:169403 )

• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:169403 )

• mammary ductal branching and alveolar budding are increased compared to in control mice

abnormal involution of the mammary gland ( J:169403 )

• delayed and incomplete with reduced apoptosis

abnormal mammary gland alveolus morphology ( J:169403 )

• alveolar structures exhibit disorganization and reduced adhesion compared to in control mice

mammary gland alveolar hyperplasia ( J:169403 )

• parous mice exhibit expanded alveolar regions with enlarged ducts and increased stromal and epithelial cells compared with control mice

increased mammary adenocarcinoma incidence ( J:169403 )

• 4 of 28 mice develop mammary tumors with a latency of 38 weeks

mammary gland hyperplasia ( J:169403 )

• at 5 to 8 months, parous mice exhibit hyperplastic foci in the mammary gland unlike control mice

increased pituitary gland tumor incidence ( J:169403 )

abnormal mammary gland epithelium physiology ( J:169403 )

• apoptosis of mammary gland epithelium during involution is decreased compared to in control mice

integument

abnormal branching of the mammary ductal tree ( J:169403 )

• mammary ductal branching and alveolar budding are increased compared to in control mice

abnormal involution of the mammary gland ( J:169403 )

• delayed and incomplete with reduced apoptosis

abnormal mammary gland alveolus morphology ( J:169403 )

• alveolar structures exhibit disorganization and reduced adhesion compared to in control mice

mammary gland alveolar hyperplasia ( J:169403 )

• parous mice exhibit expanded alveolar regions with enlarged ducts and increased stromal and epithelial cells compared with control mice

increased mammary adenocarcinoma incidence ( J:169403 )

• 4 of 28 mice develop mammary tumors with a latency of 38 weeks

mammary gland hyperplasia ( J:169403 )

• at 5 to 8 months, parous mice exhibit hyperplastic foci in the mammary gland unlike control mice

abnormal mammary gland epithelium physiology ( J:169403 )

• apoptosis of mammary gland epithelium during involution is decreased compared to in control mice

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53⁺ Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (113 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:90512 )

• about 80% develop acinar adenocarcenomas

integument

increased mammary adenocarcinoma incidence ( J:90512 )

• about 80% develop acinar adenocarcenomas

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:90512 )

• about 80% develop acinar adenocarcenomas

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (113 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:90512 )

• only a mild predisposition to mammary cancer (12%)

integument

increased mammary gland tumor incidence ( J:90512 )

• only a mild predisposition to mammary cancer (12%)

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:90512 )

• only a mild predisposition to mammary cancer (12%)

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Trp53^tm1Brd/Trp53^tm1Brd Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:90512 )

• usually succumb early to other tumors before developing mammary tumors

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (113 available)
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

integument

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

Allelic Composition	Pten^tm2Mak/Pten^tm2Mak Trp53^tm1Brn/Trp53^tm1Brn Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2Mak mutation (4 available); any Pten mutation (81 available)
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:224955 )

• females develop mammary tumors with a latency of 9.8 months

• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

increased spindle cell carcinoma incidence ( J:224955 )

• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer

increased myoepithelioma incidence ( J:224955 )

• 11% of mammary tumors are adenomyoepithelioma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

• females develop mammary tumors with a latency of 9.8 months

• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

integument

increased mammary gland tumor incidence ( J:224955 )

• females develop mammary tumors with a latency of 9.8 months

• expression analysis indicates that mammary tumors resemble human claudin-low triple-negative-like breast cancer and show more mesenchymal features

increased mammary adenocarcinoma incidence ( J:224955 )

• about 67% of tumors are classified as adeno-sacromatoid/spindle-cell/mesenchymal-like breast cancer, with the rest showing mixed mesenchymal plus adenocarcinomas or differentiated adenocarcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:224955

Allelic Composition	Pten^tm2Mak/Pten^tm2Mak Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2Mak mutation (4 available); any Pten mutation (81 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:224955 )

• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance

• nearly all mice succumb to cancer by 18 months of age

increased mammary adenocarcinoma incidence ( J:224955 )

• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

• pregnancy accelerates tumor formation

increased spindle cell carcinoma incidence ( J:224955 )

• 3% of mammary tumors are spindle-cell/adenosarcoma

increased myoepithelioma incidence ( J:224955 )

• 70% of mammary tumors are adenomyoepithelioma

integument

increased mammary gland tumor incidence ( J:224955 )

• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance

• nearly all mice succumb to cancer by 18 months of age

increased mammary adenocarcinoma incidence ( J:224955 )

• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

• pregnancy accelerates tumor formation

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:224955 )

• females develop mammary tumors after a latency of 15.2 months with almost complete penetrance

• nearly all mice succumb to cancer by 18 months of age

increased mammary adenocarcinoma incidence ( J:224955 )

• 20% of mammary tumors are adenosquamous carcinoma and 7% are acinar or poorly differentiated adenocarcinoma

increased mammary gland tumor incidence in breeding females ( J:224955 )

• pregnancy accelerates tumor formation

Allelic Composition	Esr1^tm1Sakh/Esr1^tm1Sakh Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm1Sakh mutation (0 available); any Esr1 mutation (67 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:124962 )

• mosaic mammary gland phenotype in the first lactation

abnormal branching of the mammary ductal tree ( J:124962 )

• mild defect in tertiary branching during first lactation

• aberrantly dilated ducts with few side branches during second lactation

abnormal mammary gland alveolus morphology ( J:124962 )

• some normal sized alveoli in first lactation

• regions of reduced growth in the first lactation

• fewer lobular alveoli during second lactation

abnormal lactation ( J:124962 )

• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days

• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days

• normal milk quality

integument

abnormal mammary gland morphology ( J:124962 )

• mosaic mammary gland phenotype in the first lactation

abnormal branching of the mammary ductal tree ( J:124962 )

• mild defect in tertiary branching during first lactation

• aberrantly dilated ducts with few side branches during second lactation

abnormal mammary gland alveolus morphology ( J:124962 )

• some normal sized alveoli in first lactation

• regions of reduced growth in the first lactation

• fewer lobular alveoli during second lactation

abnormal lactation ( J:124962 )

• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days

• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days

• normal milk quality

Allelic Composition	Erbb4^tm1Fej/Erbb4^tm1Fej Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:86319 )

• lobuloalveolar development retarded

abnormal mammary gland growth during lactation ( J:86319 )

• by day 3 of lactation, extensive regression occuring, complete by day 10

• epithelial proliferation declines in first day of lactation

• early development of alveolar secretory epithelium normal, terminal stages fail

abnormal lactation ( J:86319 )

• 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers

• failure of activated STAT5 to localize to nucleus

• STAT5 lacks detectable tyrosine phosphorylation

• STAT5 dependent proteins reduced

integument

abnormal mammary gland development ( J:86319 )

• lobuloalveolar development retarded

abnormal mammary gland growth during lactation ( J:86319 )

• by day 3 of lactation, extensive regression occuring, complete by day 10

• epithelial proliferation declines in first day of lactation

• early development of alveolar secretory epithelium normal, terminal stages fail

abnormal lactation ( J:86319 )

• 83% of litters born to biparous mothers die within 2 days of birth but survive when cross fostered to normal mothers

• failure of activated STAT5 to localize to nucleus

• STAT5 lacks detectable tyrosine phosphorylation

• STAT5 dependent proteins reduced

Allelic Composition	Tsg101^tm1Kuw/Tsg101^tm1Kuw Tg(Wap-cre)11738Mam/0 Tg(Wap-Tsg101)4389Kuw/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tg(Wap-Tsg101)4389Kuw mutation (1 available)
Tsg101^tm1Kuw mutation (1 available); any Tsg101 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121475 )

N	• Tsg101 transgene expression rescues mammary epithelial cells • overexpression of Tsg101 supports expansion of secretory alveolar lobules relative to conditional Tsg101 knockouts, and tissue no longer shows mosaic pattern like non Tsg101-transgenics

Allelic Composition	Phb2^tm2.1Katz/Phb2⁺ Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2^tm2.1Katz mutation (0 available); any Phb2 mutation (22 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nursing ( J:178347 )

• dams support increased weight gain in nursed pups compared with pups nursed by control mice

integument

abnormal milk composition ( J:178347 )

• expression of milk protein genes is increased compared to in control mice

endocrine/exocrine glands

abnormal milk composition ( J:178347 )

• expression of milk protein genes is increased compared to in control mice

Allelic Composition	Tsg101^tm1Kuw/Tsg101^tm1Kuw Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tsg101^tm1Kuw mutation (1 available); any Tsg101 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:121475 )

• conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene

• some regions of the mammary gland are severely underdeveloped

• terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation

• a subset of females, where recombination was inefficient are able to lactate

integument

abnormal mammary gland growth during lactation ( J:121475 )

• conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene

• some regions of the mammary gland are severely underdeveloped

• terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation

• a subset of females, where recombination was inefficient are able to lactate

Allelic Composition	Etv6^{tm3(NTRK3)Sho}/Etv6⁺ Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6^{tm3(NTRK3)Sho} mutation (0 available); any Etv6 mutation (142 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:130323 )

• nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

integument

mammary gland alveolar hyperplasia ( J:130323 )

• nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:130323

Allelic Composition	Trp53^tm3Tyj/Trp53⁺ Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:101617 )

• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy

• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks

• mammary tumors of both untreated and DMBA-treated mice are heterogeneous, including frequent adenocarcinomas, solid carcinomas, papillary carcinomas, and adenosquamous carcinomas, carcinosarcomas and sarcomas

• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

increased mammary adenocarcinoma incidence ( J:101617 )

increased incidence of tumors by chemical induction ( J:101617 )

• 40% of females exposed to DMBA for 6 weeks develop mammary tumors, with a mean latency time of 8.5 +/- 4.7 weeks

• females exposed to DMBA also develop lymphomas, ovary, lung, stomach, uterus and skin tumors

increased lymphoma incidence ( J:101617 )

• some mice develop an additional lymphoma

increased sarcoma incidence ( J:101617 )

• some mice develop an additional sarcoma in the abdomen

increased lung tumor incidence ( J:101617 )

• some mice develop an additional tumor of the lung

mortality/aging

premature death ( J:101617 )

• premature death, with only 2 of 11 mice surviving past 78 weeks

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:101617 )

• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy

• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks

• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

increased mammary adenocarcinoma incidence ( J:101617 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:101617 )

• 40% of females exposed to DMBA for 6 weeks develop mammary tumors, with a mean latency time of 8.5 +/- 4.7 weeks

• females exposed to DMBA also develop lymphomas, ovary, lung, stomach, uterus and skin tumors

integument

increased mammary gland tumor incidence ( J:101617 )

• 7 of 8 mice develop one or more tumors of the mammary gland after the first pregnancy

• mean latency time for spontaneous mammary tumor development is 19.7 +/- 8.6 weeks

• 67% of mammary tumors from untreated and DMBA-treated mice are estrogen receptor alpha-positive

increased mammary adenocarcinoma incidence ( J:101617 )

respiratory system

increased lung tumor incidence ( J:101617 )

• some mice develop an additional tumor of the lung

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:101617

Allelic Composition	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland alveolus morphology ( J:92770 )

• the number of alveoli is reduced, however females are able to successfully nurse their pups

• the alveoli that are present are distended

increased mammary gland apoptosis ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

integument

abnormal mammary gland alveolus morphology ( J:92770 )

• the number of alveoli is reduced, however females are able to successfully nurse their pups

• the alveoli that are present are distended

increased mammary gland apoptosis ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland alveolus morphology ( J:92770 )

• the number of alveoli is reduced, however females are able to successfully nurse their pups

• the alveoli that are present are distended

abnormal mammary gland epithelium physiology ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

increased mammary gland apoptosis ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

integument

abnormal mammary gland alveolus morphology ( J:92770 )

• the number of alveoli is reduced, however females are able to successfully nurse their pups

• the alveoli that are present are distended

abnormal mammary gland epithelium physiology ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

increased mammary gland apoptosis ( J:92770 )

• increased apoptosis is seen in the mammary epithelium during late pregnancy

Allelic Composition	Brca1^tm1Cxd/Brca1^tm2Cxd Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm1Cxd mutation (1 available); any Brca1 mutation (113 available)
Brca1^tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:54533 )

• at pregnancy day 8.5, mammary glands are smaller than controls

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

neoplasm

increased mammary gland tumor incidence ( J:54533 )

• 2 of 13 female mice developed mammary tumors of diverse types

endocrine/exocrine glands

abnormal mammary gland development ( J:54533 )

• developmental defects may correlate with apoptosis observed in mutant mammary glands

abnormal branching of the mammary ductal tree ( J:54533 )

• abnormal ductal morphogenesis was observed at lactation and involution

abnormal involution of the mammary gland ( J:54533 )

• residual alveolar structures sometimes remain in involuting mammary glands

abnormal mammary gland growth during pregnancy ( J:54533 )

• at pregnancy day 8.5, mammary glands are smaller than controls

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

increased mammary gland tumor incidence ( J:54533 )

• 2 of 13 female mice developed mammary tumors of diverse types

integument

abnormal mammary gland development ( J:54533 )

• developmental defects may correlate with apoptosis observed in mutant mammary glands

abnormal branching of the mammary ductal tree ( J:54533 )

• abnormal ductal morphogenesis was observed at lactation and involution

abnormal involution of the mammary gland ( J:54533 )

• residual alveolar structures sometimes remain in involuting mammary glands

abnormal mammary gland growth during pregnancy ( J:54533 )

• at pregnancy day 8.5, mammary glands are smaller than controls

• at pregnancy day 16.5, mammary development is incomplete with fat pads that are less than 80% filled in the most severely affected mutants

increased mammary gland tumor incidence ( J:54533 )

• 2 of 13 female mice developed mammary tumors of diverse types

Allelic Composition	Bin1^tm1Gcp/Bin1^tm2Gcp Tg(MMTV-Myc)141-3Led/0 Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin1^tm1Gcp mutation (0 available); any Bin1 mutation (27 available)
Bin1^tm2Gcp mutation (1 available); any Bin1 mutation (27 available)
Tg(MMTV-Myc)141-3Led mutation (1 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117330 )

increased lymphoma incidence ( J:117330 )

• some mice develop aggressive lymphomas which occasionally appear before mammary carcinomas

cellular

abnormal cell physiology ( J:117330 )

• tumor cells show increased motility in monolayer culture

decreased apoptosis ( J:117330 )

• tumor cells in culture show several fold greater resistance to serum deprivation-induced apoptosis

increased cell proliferation ( J:117330 )

• tumor cells show 3-4 fold higher rates of proliferation under anchorage-dependent conditions

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:117330 )

• tumor cells have higher gelatinase activity

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117330 )

integument

increased mammary adenocarcinoma incidence ( J:117330 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:117730

Allelic Composition	Bin1^tm1Gcp/Bin1^tm2Gcp Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:117330 )

• ductolobular regression was achieved with somewhat slower kinetics in mutant mice during glandular involution after pregnancy

abnormal mammary gland embryonic development ( J:117330 )

• a delay in the kinetics of ductolobular development was apparent at 18.5 dpc, when mutant mice showed significantly less glandular remodeling

• at 7.5 dpp, this defect had resolved, such that no deficiencies were apparent in nursing and pups showed no signs of malnutrition

increased mammary gland tumor incidence ( J:117330 )

• 8% of elderly animals of >1 year of age exhibited developed poorly differentiated tumors

• DMBA treated animals developed poorly differentiated tumors, characterized by low tubule formation, high mitotic indices, and high degrees of nuclear pleomorphism and relative increase in lymphocyte infiltration compared with mice carrying one wild-type allele of Bin1

increased granulosa cell tumor incidence ( J:117330 )

• ovarian granulosa cell tumors are noted

• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

neoplasm

increased mammary gland tumor incidence ( J:117330 )

• 8% of elderly animals of >1 year of age exhibited developed poorly differentiated tumors

increased granulosa cell tumor incidence ( J:117330 )

• ovarian granulosa cell tumors are noted

• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

increased incidence of tumors by chemical induction ( J:117330 )

• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:117330 )

• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

immune system

endometrium inflammation ( J:117330 )

• elevation in uterine endometritis

integument

abnormal involution of the mammary gland ( J:117330 )

• ductolobular regression was achieved with somewhat slower kinetics in mutant mice during glandular involution after pregnancy

abnormal mammary gland embryonic development ( J:117330 )

• a delay in the kinetics of ductolobular development was apparent at 18.5 dpc, when mutant mice showed significantly less glandular remodeling

• at 7.5 dpp, this defect had resolved, such that no deficiencies were apparent in nursing and pups showed no signs of malnutrition

increased mammary gland tumor incidence ( J:117330 )

• 8% of elderly animals of >1 year of age exhibited developed poorly differentiated tumors

reproductive system

increased granulosa cell tumor incidence ( J:117330 )

• ovarian granulosa cell tumors are noted

• increased incidence of DMBA-induced ovarian granulosa cell tumors in mutant mice (43%) relative to mice carrying one wild-type copy of Bim1 (13%), all of whom also had mammary tumors

endometrium inflammation ( J:117330 )

• elevation in uterine endometritis

Allelic Composition	Bin1^tm2Gcp/Bin1⁺ Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bin1^tm2Gcp mutation (1 available); any Bin1 mutation (27 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:117330 )

• 5% of elderly animals of >1 year of age developed mammary tumors

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

increased incidence of tumors by chemical induction ( J:117330 )

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:117330 )

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:117330 )

• 5% of elderly animals of >1 year of age developed mammary tumors

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

integument

increased mammary gland tumor incidence ( J:117330 )

• 5% of elderly animals of >1 year of age developed mammary tumors

• DMBA-treated animals developed well-differentiated tumors, characterized by high tubule formation, low mitotic indices, and limited nuclear pleomorphism

Allelic Composition	Stat1^tm1Mam/Stat1^tm1Mam Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat1^tm1Mam mutation (1 available); any Stat1 mutation (72 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:169262 )

N	• female mice exhibit normal mammary gland architecture

Allelic Composition	Jak2^tm1Kuw/Jak2^tm1Kuw Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2^tm1Kuw mutation (1 available); any Jak2 mutation (57 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:90883 )

• differentiated mammary epithelia that expressed the Tg(Wap-cre)11738Mam transgene were not maintained during lactation; these Jak2 deficient cells appeared during the first few days of lactation, then were absent for the remainder of the lactation period

integument

abnormal mammary gland growth during lactation ( J:90883 )

Allelic Composition	Arnt^tm1Gonz/Arnt^tm1Gonz Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Gonz mutation (0 available); any Arnt mutation (62 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:76280 )

N	• mammary gland development is normal and females are able to raise litters even after several pregnancies

Allelic Composition	Ctnna1^tm1Efu/Ctnna1^tm1Efu Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1^tm1Efu mutation (1 available); any Ctnna1 mutation (133 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:87469 )

• pups with homozygous mothers weight 50% of normal mice

postnatal growth retardation ( J:87469 )

• pups with homozygous mothers fail to thrive

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:87469 )

• mammary glands have reduced numbers of epithelial cells

• some epithelial cells remain condensed and disorganized without forming alveolar structures

• lumens are absent from clusters of epithelium

abnormal milk composition ( J:87469 )

• milk proteins are reduced

increased mammary gland apoptosis ( J:87469 )

• apoptosis in mammary epithelium is increased

integument

abnormal mammary gland epithelium morphology ( J:87469 )

• mammary glands have reduced numbers of epithelial cells

• some epithelial cells remain condensed and disorganized without forming alveolar structures

• lumens are absent from clusters of epithelium

abnormal milk composition ( J:87469 )

• milk proteins are reduced

increased mammary gland apoptosis ( J:87469 )

• apoptosis in mammary epithelium is increased

cellular

maternal effect ( J:87469 )

• pups with homozygous mothers fail to thrive, are about 50% of normal weight and some do not survive lactation

• in litters that experience lethality, the litters are reduced to 50% at day 5 and 25% by day 10

Allelic Composition	Pparg^tm1Gonz/Pparg^tm1Gonz Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pparg^tm1Gonz mutation (0 available); any Pparg mutation (39 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:76553 )

N	• mice have normal mammary gland development

Allelic Composition	Jak1^tm1Kuw/Jak1^tm1Kuw Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak1^tm1Kuw mutation (1 available); any Jak1 mutation (50 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:235354 )

• delay in postlactational remodeling of the mammary gland

integument

abnormal involution of the mammary gland ( J:235354 )

• delay in postlactational remodeling of the mammary gland

Allelic Composition	Nit1^tm1Hbn/Nit1^tm1Hbn Tg(Wap-cre)11738Mam/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1^tm1Hbn mutation (0 available); any Nit1 mutation (15 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:115052 )

• there is only a small significant difference in number of branch points during pregnancy

• at mid-pregnant stages (day13 and 16), number of endbuds is significantly increased compared to controls

• null mammary glands show an increase in ductal structures; lobuloalveolar structures are better developed at later times during pregnancy compared to controls

integument

abnormal branching of the mammary ductal tree ( J:115052 )

• there is only a small significant difference in number of branch points during pregnancy

• at mid-pregnant stages (day13 and 16), number of endbuds is significantly increased compared to controls

• null mammary glands show an increase in ductal structures; lobuloalveolar structures are better developed at later times during pregnancy compared to controls

Allelic Composition	Chek1^tm1Jmr/Chek1⁺ Tg(Wap-cre)11738Mam/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm1Jmr mutation (1 available); any Chek1 mutation (41 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cell proliferation ( J:91266 )

• about 35% of cells in the mammary glands are proliferating at day 1 of lactation compared to 6.5% in wild-type

Allelic Composition	Chek1^tm1Jmr/Chek1^tm1Jmr Tg(Wap-cre)11738Mam/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek1^tm1Jmr mutation (1 available); any Chek1 mutation (41 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal apoptosis ( J:91266 )

• about 10% - 12% is seen in the differentiating lobuloalveolar mammary epithelial cells compared to less than 1% in wild-type

decreased cell proliferation ( J:91266 )

• about 4% of cells in the mammary glands are proliferating at day 1 of lactation compared to 6.5% in wild-type

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:91266 )

• the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

abnormal lactation ( J:91266 )

• females fail to nurse their young

reproductive system

abnormal mammary gland growth during pregnancy ( J:91266 )

• the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

integument

abnormal mammary gland growth during pregnancy ( J:91266 )

• the number of lobuloalveolar mammary epithelial cells is reduced by 50% to 60% at day 1 of lactation in proportion to the number of cells expressing cre

abnormal lactation ( J:91266 )

• females fail to nurse their young

Allelic Composition	Phb2^tm2.1Katz/Phb2^tm2.1Katz Tg(Wap-cre)11738Mam/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2^tm2.1Katz mutation (0 available); any Phb2 mutation (22 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal nursing ( J:178347 )

• dams do not support the growth of nursing pups who exhibit reduced weight gain compared with pups nursed by control mice

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:178347 )

• dramatically accelerated

abnormal mammary gland growth during lactation ( J:178347 )

• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice

abnormal mammary gland alveolus morphology ( J:178347 )

• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice

• 3 days after weaning, mice exhibit collapse of alveoli unlike control mice

abnormal milk composition ( J:178347 )

• expression of milk protein genes is decreased compared to in control mice

increased mammary gland apoptosis ( J:178347 )

• in differentiated mammary epithelial cells during lactation

integument

abnormal involution of the mammary gland ( J:178347 )

• dramatically accelerated

abnormal mammary gland growth during lactation ( J:178347 )

• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice

abnormal mammary gland alveolus morphology ( J:178347 )

• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice

• 3 days after weaning, mice exhibit collapse of alveoli unlike control mice

abnormal milk composition ( J:178347 )

• expression of milk protein genes is decreased compared to in control mice

increased mammary gland apoptosis ( J:178347 )

• in differentiated mammary epithelial cells during lactation

Allelic Composition	Tsg101^tm1Kuw/Tsg101^tm1Kuw Tg(Wap-cre)11738Mam/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Wap-cre)11738Mam mutation (3 available)
Tsg101^tm1Kuw mutation (1 available); any Tsg101 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:80891 )

N	• mice up to 24 months of age did not develop any mammary gland lesions

endocrine/exocrine glands

abnormal mammary gland development ( J:80891 )

• severe inhibition of normal mammary gland development

abnormal mammary gland growth during lactation ( J:80891 )

• alveolar development is severely impaired

• mutants unable to initiate lactation exhibit alveolar compartment regression after several days

abnormal lactation ( J:80891 )

• 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies

integument

abnormal mammary gland development ( J:80891 )

• severe inhibition of normal mammary gland development

abnormal mammary gland growth during lactation ( J:80891 )

• alveolar development is severely impaired

• mutants unable to initiate lactation exhibit alveolar compartment regression after several days

abnormal lactation ( J:80891 )

• 60% of mice were completely unable to lactate after their first pregnancy; however, a small number of mice were able to establish lactation in their second or third pregnancies

Allelic Composition	Il6st^tm1Mam/Il6st^tm1Mam Tg(Wap-cre)11738Mam/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Mam mutation (0 available); any Il6st mutation (80 available)
Tg(Wap-cre)11738Mam mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:93986 )

• involution of the mammary gland following weaning of offspring is greatly impaired

integument

abnormal involution of the mammary gland ( J:93986 )

• involution of the mammary gland following weaning of offspring is greatly impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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