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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mx1-cre)1Cgn
transgene insertion 1, University of Cologne
MGI:2176073
Summary 297 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdkn1atm1Led/Cdkn1atm1Led
Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn MGI:5294434
cn2
Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Cdkn1ctm2.1Kei Tg(Mx1-cre)1Cgn MGI:5294433
cn3
Dll4tm1Frad/Dll4tm1Frad
Tg(Mx1-cre)1Cgn/0
B6.Cg-Dll4tm1Frad Tg(Mx1-cre)1Cgn MGI:3828267
cn4
Dnmt3atm1Trow/Dnmt3a+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Dnmt3atm1Trow Tg(Mx1-cre)1Cgn MGI:6286132
cn5
F2tm1Jld/F2tm1Jld
Tg(Mx1-cre)1Cgn/0
B6.Cg-F2tm1Jld Tg(Mx1-cre)1Cgn MGI:3831698
cn6
Fastm1Cgn/Fastm1Cgn
Tg(Mx1-cre)1Cgn/0
B6.Cg-Fastm1Cgn Tg(Mx1-cre)1Cgn MGI:3690550
cn7
Flt3tm1Dosm/Flt3+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn MGI:3819966
cn8
Fth1tm1.1Lck/Fth1tm1.1Lck
Tg(Mx1-cre)1Cgn/0
B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn MGI:4848041
cn9
Dnmt3atm1Trow/Dnmt3a+
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Tg(Mx1-cre)1Cgn/0
B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow Dnmt3atm1Trow Tg(Mx1-cre)1Cgn MGI:6286136
cn10
Inpp5dtm1Wgk/Inpp5dtm1.1Wgk
Tg(Mx1-cre)1Cgn/0
B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn MGI:3830385
cn11
Inpp5dtm1Wgk/Inpp5dtm1Wgk
Tg(Mx1-cre)1Cgn/0
B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn MGI:3830386
cn12
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
Tg(Mx1-cre)1Cgn/0
B6.Cg-Rb1cc1tm1.1Guan Tg(Mx1-cre)1Cgn MGI:4936844
cn13
Rictortm1.1Klg/Rictortm1.1Klg
Tg(Mx1-cre)1Cgn/0
B6.Cg-Rictortm1.1Klg Tg(Mx1-cre)1Cgn MGI:5448842
cn14
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu MGI:5787932
cn15
Srsf2tm1.1Oaw/Srsf2+
Tg(Mx1-cre)1Cgn/?
B6.Cg-Tg(Mx1-cre)1Cgn Srsf2tm1.1Oaw MGI:5695364
cn16
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu MGI:4839500
cn17
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Tg(Mx1-cre)1Cgn/0
involves: 129 * BALB/c * C57BL/6 * CBA MGI:3758714
cn18
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Rnf2tm1Mvi/Rnf2tm1Mvi
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL MGI:3772194
cn19
Atg7tm1Tchi/Atg7tm1Tchi
Sqstm1tm1Keta/Sqstm1tm1Keta
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj MGI:3806622
cn20
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:5524225
cn21
Bcl11atm1Pwt/Bcl11atm1Pwt
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:5515309
cn22
Rgs12tm1.1Syy/Rgs12tm1.1Syy
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:5490966
cn23
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:2680169
cn24
Jag1tm1Frad/Jag1tm1Frad
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:3578403
cn25
Jag1tm1Frad/Jag1tm1Frad
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:3578401
cn26
Mtf1tm2Wsc/Mtf1tm2Wsc
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:3618356
cn27
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Rb1tm2Brn/Rb1tm2Brn
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:5468652
cn28
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA MGI:2448711
cn29
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Mx1-cre)1Cgn/?
involves: 129 * C57BL/6 * CBA/Ca MGI:5525154
cn30
Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA * SJL MGI:5009036
cn31
Mllt10tm1Saam/Mllt10tm1Saam
Tg(Mx1-cre)1Cgn/?
involves: 129 * C57BL/6J * CBA/J MGI:5708137
cn32
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Tg(Mx1-cre)1Cgn/0
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * CBA MGI:5427983
cn33
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3608663
cn34
Lrrc17tm1Nik/Lrrc17+
Nf1tm1Par/Nf1tm1Par
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4460776
cn35
Pax5tm1Mbu/Pax5tm3Mbu
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA MGI:3720351
cn36
Ptentm1Hwu/Ptentm1Hwu
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4944270
cn37
Krastm4Tyj/Kras+
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4460775
cn38
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA MGI:4839763
cn39
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA MGI:5009039
cn40
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA MGI:5009045
cn41
Stat3tm1Vpo/Stat3tm1Vpo
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA MGI:3040656
cn42
Furintm1Jwmc/Furintm1.1Jwmc
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6J * CBA MGI:3700792
cn43
Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA MGI:3706809
cn44
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:4460774
cn45
F2tm1Jld/F2tm1Sjd
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:3831696
cn46
Ruvbl1tm1.1Oxbk/Ruvbl1tm1.1Oxbk
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA/J * SJL MGI:5762869
cn47
Csktm1Tara/Csktm1Tara
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CB20 * CBA MGI:3050322
cn48
Runx1tm2Buch/Runx1tm2Buch
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3798078
cn49
Upf2tm1Btp/Upf2tm1Btp
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3797491
cn50
Anapc2tm1Kna/Anapc2tm2Kna
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3686618
cn51
Supv3l1tm2Jkl/Supv3l1tm2Jkl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3833883
cn52
Nf2tm2Gth/Nf2tm2Gth
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3850479
cn53
Spi1tm2.1Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3688720
cn54
Spi1tm2Dgt/Spi1tm2Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3688721
cn55
Raf1tm2Bacc/Raf1tm2Bacc
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3511182
cn56
Ezh2tm1Tara/Ezh2tm1Tara
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2661102
cn57
Il2rgtm2Cgn/Y
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3776484
cn58
Tln1tm4.1Crit/Tln1tm4.1Crit
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3772491
cn59
Pou5f1tm1Scho/Pou5f1tm1Scho
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3772212
cn60
Egfrtm1Msi/Egfrtm1Msi
Tg(Mx1-cre)1Cgn/?
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3763539
cn61
Adam17tm1Bbl/Adam17tm1Bbl
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3810471
cn62
Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3047603
cn63
Cd79atm4Cgn/Cd79atm4.1Cgn
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3047599
cn64
Juntm4Wag/Juntm4Wag
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2451303
cn65
Tcf3tm1(TCF3/HLF)Homy/Tcf3+
Tg(Emu-Zfp521)#Homy/0
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4458210
cn66
Tcf3tm1(TCF3/HLF)Homy/Tcf3+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4458207
cn67
Ikzf1tm1(Pax5)Mbu/Ikzf1tm1(Pax5)Mbu
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2653526
cn68
Ezh2tm1Tara/Ezh2tm1Tara
Ightm2Cgn/?
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4440625
cn69
Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+
Npm1tm1Gsva/Npm1+
TgTn(pb-sb-GrOnc)#aGsva/0
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:5007701
cn70
Rps6tm1Gtho/Rps6tm1Gtho
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3041081
cn71
Braftm1Cpri/Braf+
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3617228
cn72
Rbpjtm1Hon/Rbpjtm1Hon
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3603011
cn73
Espl1tm1.1Kna/Espl1tm1.1Kna
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3625271
cn74
Usp8tm1.1Kpk/Usp8tm1.1Kpk
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:3716591
cn75
Igktm1.1Cog/Igktm1.2Cog
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:3797406
cn76
Igktm1.1Cog/Igktm1.1Cog
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:3797407
cn77
Myctm2.1Atp/Myctm2.1Atp
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL MGI:3811825
cn78
Myctm1Atp/Myctm2.1Atp
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N * SJL MGI:3811820
cn79
Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
Tg(Tal1-tTA)19Dgt/0
Tg(tetO-BCR/ABL1)2Dgt/0
TgTn(pb-sb-GrOnc)#aGsva/0
involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N MGI:5806781
cn80
Gt(ROSA)26Sortm4(CAG-hsb5)Nki/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
Tg(tetO-BCR/ABL1)2Dgt/0
TgTn(pb-sb-GrOnc)#aGsva/0
involves: 129P2/OlaHsd * C57BL/6 * CBA/J * FVB/N MGI:5806786
cn81
Dnase2atm1Osa/Dnase2atm2Osa
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 * CBA MGI:3692382
cn82
Gfi1tm5.1(GFI1*)Tmo/Gfi1tm5.1(GFI1*)Tmo
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:5468269
cn83
Gfi1tm5.1(GFI1*)Tmo/Gfi1+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:5468270
cn84
Gfi1tm6.1(GFI1)Tmo/Gfi1tm6.1(GFI1)Tmo
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:5468271
cn85
Etv6tm1(RUNX1)Haho/Etv6+
Runx1tm3Spe/Runx1+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA MGI:4356086
cn86
Etv6tm1(RUNX1)Haho/Etv6+
Runx1tm3Spe/Runx1tm3Spe
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 * CBA MGI:4356085
cn87
Smarcb1tm1Sho/Smarcb1tm3Sho
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA MGI:3819385
cn88
Smarcb1tm1Sho/Smarcb1tm2Sho
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA MGI:3819384
cn89
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N MGI:3706857
cn90
Itgavtm1Blb/Itgavtm1Blb
Itgb1tm1Ref/Itgb1tm1Ref
Itgb2tm2Bay/Itgb2tm2Bay
Itgb7tm1Cgn/Itgb7tm1Cgn
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA MGI:4358370
cn91
Rnf2tm1Mvi/Rnf2tm1Mvi
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10 * CBA MGI:3772192
cn92
Ep400tm3Fuku/Ep400tm3.1Fuku
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4845885
cn93
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:2669328
cn94
Itgb1tm1Ref/Itgb1tm1Ref
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3770647
cn95
Crbntm1.1Ble/Crbntm1.1Ble
Csnk1a1tm1.1Ybn/Csnk1a1+
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:6280334
cn96
Gfi1tm1Wep/Gfi1tm1Wep
Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4868585
cn97
Gbatm1Karl/Gbatm1.1Karl
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3688418
cn98
Adartm1.1Phs/Adartm2Phs
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3828311
cn99
Fn1tm1Ref/Fn1tm1Ref
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3663319
cn100
Nf1tm1Par/Nf1tm1Par
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5544056
cn101
Gfi1btm2Tmo/Gfi1btm2Tmo
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4868582
cn102
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5517427
cn103
Casp8tm1Wll/Casp8tm1.1Yuan
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * MF1 MGI:3055107
cn104
Vcam1tm2Flv/Vcam1tm2Flv
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3845664
cn105
Etv6tm2Sho/Etv6tm2Sho
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * C57BL/6 * CBA MGI:3056264
cn106
Runx1tm1(RUNX1)Gcg/Runx1tm1(RUNX1)Gcg
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3621942
cn107
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3701504
cn108
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3701505
cn109
Zbtb7atm1Ppp/Zbtb7atm2Ppp
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3711414
cn110
Gt(ROSA)26Sortm1(EWSR1/FLI1)Sbk/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * C57BL/6 * CBA MGI:3769116
cn111
Kmt2atm1Saam/Kmt2a+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:3814579
cn112
Vcam1tm2Roml/Vcam1tm2Roml
Tg(Mx1-cre)1Cgn/?
involves: 129S1/Sv * C57BL/6 * CBA MGI:3841674
cn113
Etv6tm1(RUNX1)Haho/Etv6+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:4356082
cn114
Tal1tm3Wehi/Tal1tm2Wehi
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:2450773
cn115
Rapgef2tm1.1Hous/Rapgef2tm1.1Hous
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:4839184
cn116
Ezh2tm2Sho/Ezh2tm2Sho
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:5316002
cn117
Ezh2tm2Sho/Ezh2tm2.1Sho
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA MGI:5316003
cn118
Foxo1tm1Rdp/Foxo1tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA * FVB/N MGI:3706814
cn119
Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA * FVB/N MGI:3699352
cn120
Slc20a1tm1.1Lbek/Slc20a1tm1.1Lbek
Tg(Mx1-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA MGI:5474455
cn121
Asb2tm1.1Lutz/Asb2tm1.1Lutz
Tg(Mx1-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * CBA MGI:5517671
cn122
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Tg(Mx1-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * CBA * SJL MGI:3839882
cn123
Mybl2tm1.1Jof/Mybl2tm1.1Jof
Tg(Mx1-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * CBA * SJL MGI:3613614
cn124
Runx1tm3Spe/Runx1tm3Spe
U2af1tm1.1Hev/U2af1+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 * CBA/J MGI:6273496
cn125
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA MGI:3035835
cn126
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA MGI:5007630
cn127
Nfatc1tm3Glm/Nfatc1tm3Glm
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3831754
cn128
Faddtm1Wnt/Faddtm1Wnt
Tg(Fadd/EGFP)#Jizh/?
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJae * C57BL/6 * CBA MGI:4943260
cn129
Flvcr1tm1Jlab/Flvcr1tm1Jlab
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3807529
cn130
Msi2tm1.1Cjl/Msi2tm1.1Cjl
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5588140
cn131
Runx1tm3Spe/Runx1tm3Spe
Spi1tm2.1Dgt/Spi1tm2.1Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3793733
cn132
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5582314
cn133
Runx1tm3Spe/Runx1tm3Spe
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3793732
cn134
Mttptm2Sgy/Mttptm2Sgy
Tg(Mx1-cre)1Cgn/Tg(Mx1-cre)1Cgn
involves: 129S4/SvJae * C57BL/6 * CBA MGI:2663704
cn135
Gna12tm1.1Cgh/Gna12tm1.1Cgh
Gna13tm2Cgh/Gna13tm2Cgh
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5140845
cn136
Icmttm1Mbrg/Icmttm1Mbrg
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3033713
cn137
Sphk1tm1.1Cgh/Sphk1tm2Cgh
Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:3708981
cn138
Hdac1tm1Ics/Hdac1tm1Ics
Hdac2tm1.1Rdp/Hdac2+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5494631
cn139
Hdac1tm1Ics/Hdac1tm1Ics
Hdac2tm1.1Rdp/Hdac2tm1.1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5494633
cn140
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:4836620
cn141
Bcl11atm1Pwt/Bcl11atm1Pwt
Dnmt1tm2Jae/Dnmt1+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5515307
cn142
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA/J MGI:5688867
cn143
Pkn3tm1.1Mrl/Pkn3+
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA/J MGI:5688868
cn144
Sf3b1tm1.1Mdf/Sf3b1+
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJae * C57BL/6 * CBA/J MGI:5823482
cn145
Mirc1tm1Tyj/Mirc1tm1Tyj
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA * SJL MGI:3796149
cn146
Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Krastm4Tyj/Kras+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6J * C57BL/6N * CBA/J MGI:6267351
cn147
Rps14tm1.1Ble/Rps14+
Tg(Mx1-cre)1Cgn/0
Trp53tm2.1Tyj/Trp53+
involves: 129S4/SvJae * C57BL/6J * C57BL/6NTac * CBA/J MGI:6148310
cn148
Srsf2tm1Xdfu/Srsf2tm1Xdfu
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJae * C57BL/6J * CBA/J MGI:5695464
cn149
Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA MGI:5014819
cn150
Gfi1btm1.1Haho/Gfi1btm1.1Haho
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:5558065
cn151
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:4868733
cn152
Itga4tm1Tpa/Itga4tm1Tpa
Tg(Mx1-cre)1Cgn/?
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:2684121
cn153
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Rb1tm2Brn/Rb1tm2Brn
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:5468653
cn154
Etv2tm1Dlim/Etv2tm2.1Dlim
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:5009245
cn155
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:4868732
cn156
Adam10tm1.1Khr/Adam10tm1.1Khr
Csf3rtm1Link/Csf3rtm1Link
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6N MGI:5305469
cn157
Tg(Mx1-cre)1Cgn/0
U2af1tm1.1Hev/U2af1+
involves: 129S6/SvEvTac * BALB/c * C57BL/6 * C57BL/6J * CBA/J MGI:6273483
cn158
Ptpn11tm1Ckq/Ptpn11+
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA MGI:5295465
cn159
Adam10tm1.1Khr/Adam10tm1.1Khr
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N MGI:5305470
cn160
Gt(ROSA)26Sortm3(CAG-EYFP)Hze/Gt(ROSA)26Sor+
Stat5atm2Mam Stat5btm1Mam/Del(11Stat5a-Stat5b)1Mam
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA MGI:5544442
cn161
Stat5btm1Mam/Stat5btm1Mam
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:4847918
cn162
Ptpn11tm6Bgn/Ptpn11+
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3845014
cn163
Hdac3tm1Swh/Hdac3tm1.1Swh
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3795938
cn164
Zfxtm1.1Reiz/Y
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3848805
cn165
Pbx1tm1Mlc/Pbx1tm3.1Mlc
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:4352856
cn166
Cbfbtm1Lhc/Cbfbtm1Lhc
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3615391
cn167
Stat5atm2Mam/Stat5atm2Mam
Stat5btm1Mam/Stat5btm1Mam
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:4847917
cn168
Cebpatm1Dgt/Cebpatm1Dgt
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3525184
cn169
Xbp1tm2Glm/Xbp1tm2Glm
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:3811310
cn170
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N MGI:3706818
cn171
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N MGI:3706822
cn172
Ptpmt1tm2.1Ckq/Ptpmt1tm2.1Ckq
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:5485992
cn173
Actl6atm1.1Grc/Actl6atm1.1Grc
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6J * CBA MGI:5465445
cn174
Actl6atm1.1Grc/Actl6a+
Tg(Mx1-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6J * CBA MGI:5465446
cn175
Tnfaip3tm1Homy/Tnfaip3tm1Homy
Tg(Mx1-cre)1Cgn/?
involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5698264
cn176
Ccna1tm1Djw/Ccna1tm1Djw
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:4461991
cn177
Rad50tm1Jpt/Rad50tm3Jpt
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3832542
cn178
Tcratm1Cgn/Tcratm1Cgn
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3814172
cn179
Jak2tm1(JAK2)Argr/Jak2+
Tg(Mx1-cre)1Cgn/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:4836619
cn180
Sf3b1tm1.1Mdf/Sf3b1+
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(Mx1-cre)1Cgn/?
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J MGI:5823559
cn181
Cxcr2tm1Rmra/Cxcr2tm1Rmra
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * CBA MGI:5532706
cn182
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA MGI:5141144
cn183
Atg5tm1Myok/Atg5tm1Myok
Tg(Mx1-cre)1Cgn/?
involves: 129S/SvEv * C57BL/6 * CBA MGI:3713122
cn184
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tet2tm1.1Iaai/Tet2tm1.1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA MGI:5575664
cn185
Asxl1tm1.1Iaai/Asxl1tm1.1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA MGI:5575661
cn186
Cul4a/Pcid2tm2Ktc/Cul4a/Pcid2tm2Ktc
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N MGI:3851123
cn187
Cul4a/Pcid2tm2Ktc/Cul4a/Pcid2tm2Ktc
Tg(Mx1-cre)1Cgn/0
involves: 129S/SvEv * C57BL/6 * CBA * FVB/N MGI:3805575
cn188
Terf2tm1Tdl/Terf2tm1.1Tdl
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:3700173
cn189
Nbntm1Md/Nbntm1Zqw
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:3510438
cn190
Mapk1tm2Moga/Mapk1tm2Moga
Mapk3tm1Gpg/Mapk3tm1Gpg
Tg(Mx1-cre)1Cgn/?
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:3797232
cn191
Tln1tm4.1Crit/Tln1tm4.1Crit
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:4358372
cn192
Sox17tm1Sjm/Sox17tm2Sjm
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA MGI:3717921
cn193
Gmnntm1Tjm/Gmnntm1Tjm
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * C57BL/6J * CBA MGI:4999652
cn194
Fli1tm1Morl/Fli1tm1Morl
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA MGI:4878939
cn195
Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(Mx1-cre)1Cgn/0
Tg(UBC-Mtf1)1Wsc/0
involves: 129/Sv * C57BL/6 * CBA MGI:3046551
cn196
Vegfatm2Gne/Vegfatm2Gne
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA MGI:2183820
cn197
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA MGI:3802922
cn198
Itgb1tm3Mlkn/Itgb1tm3Mlkn
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA MGI:3639582
cn199
Igf1tm1Dlr/Igf1tm1Dlr
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA MGI:2176943
cn200
Numbtm1Zili/Numbtm1Zili
Numbltm1Zili/Numbltm1Zili
Tg(Mx1-cre)1Cgn/?
involves: 129/Sv * C57BL/6 * CBA MGI:3783760
cn201
Fli1tm1Morl/Fli1tm1.1Morl
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA * DBA MGI:4878945
cn202
Rbm15tm1Dgg/Rbm15tm1.1Dgg
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6 * CBA * FVB/N MGI:3710771
cn203
Dyrk1atm1Jdc/Dyrk1atm1Jdc
Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C57BL/6J * C57BL/6NTac * CBA/J MGI:5660267
cn204
Arnttm1Gonz/Arnttm1Gonz
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:2176697
cn205
Mcl1tm2Sjk/Mcl1tm3Sjk
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:2684174
cn206
Kmt2atm2Sjk/Kmt2a+
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3529267
cn207
Tasp1tm1Jjdh/Tasp1tm1Jjdh
Tg(Mx1-cre)1Cgn/?
involves: 129X1/SvJ * C57BL/6 * CBA MGI:3687261
cn208
Hip1tm4Tsr/Hip1+
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:4356328
cn209
Hip1tm4Tsr/Hip1+
Runx1tm3Dow/Runx1+
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:4356330
cn210
Rbm15tm1Swm/Rbm15tm1Swm
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:4357951
cn211
Bcl11atm1Pwt/Bcl11atm1Pwt
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:5564909
cn212
Mybl2tm1.1Epr/Mybl2tm1.1Epr
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N MGI:5577184
cn213
Ppargtm1.1Gonz/Ppargtm1.1Gonz
Tg(Mx1-cre)1Cgn/?
involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N MGI:3722298
cn214
Notch2tm1Frad/Notch2tm1Frad
Tg(Mx1-cre)1Cgn/0
involves: BALB/c * C57BL/6 * CBA MGI:3758713
cn215
Smarcc1tm2.1Rhs/Smarcc1tm2.1Rhs
Tg(Mx1-cre)1Cgn/0
involves: BALB/c * C57BL/6 * CBA MGI:5426682
cn216
Sbdstm1Aljw/Sbdstm1.1Aljw
Tg(Mx1-cre)1Cgn/0
involves: BALB/cJ * C57BL/6 * DBA MGI:5007536
cn217
Dll1tm1Mjo/Dll1tm1Mjo
Tg(KRT5-cre)1Tak/?
Tg(Mx1-cre)1Cgn/?
involves: C3H * C57BL/6 * CBA MGI:3045468
cn218
Tg(Mx1-cre)1Cgn/0
Znrf1tm1Lchs/Znrf1tm1Lchs
involves: C57BL/6 MGI:6369077
cn219
Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA MGI:5517428
cn220
Tg(Mx1-cre)1Cgn/0
Zmiz1tm1c(EUCOMM)Hmgu/Zmiz1tm1c(EUCOMM)Hmgu
involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA/J MGI:5795897
cn221
C1galt1tm1.1Staka/C1galt1tm1.2Staka
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * CBA * DBA/2 MGI:5524268
cn222
Atp6ap2tm1.1Aich/Atp6ap2tm1.1Aich
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * CBA/J MGI:6357744
cn223
Atp6ap2tm1.1Aich/Y
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * CBA/J MGI:6357747
cn224
Tcf3tm1(PBX1)Mlc/Tcf3+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6J * CBA/J MGI:5825359
cn225
Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6N * CBA MGI:5762598
cn226
Csnk1a1tm1c(KOMP)Wtsi/Csnk1a1tm1c(KOMP)Wtsi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * C57BL/6N * CBA MGI:5762596
cn227
Tg(Mx1-cre)1Cgn/0
Thoc5tm1Tate/Thoc5tm1Tate
involves: C57BL/6 * CBA MGI:4946273
cn228
Bcl11atm1Pwt/Bcl11atm1Pwt
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5515308
cn229
Tg(Kit*D814V)3Roer/0
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4942362
cn230
Tg(Kit*D814V)2Roer/0
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4942361
cn231
Tg(Kit*D814V)1Roer/0
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4942360
cn232
Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4868728
cn233
Fbxw7tm2Iaai/Fbxw7+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5524227
cn234
Eef1a1tm1(FBXW7*)Iaai/Eef1a1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5524229
cn235
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5525098
cn236
Gbatm1.1Pmis/Gbatm1.2Pmis
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4867689
cn237
Tcratm1Cgn/Tcratm1Mass
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5532665
cn238
Tcratm1Cgn/Tcratm1Cgn
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5532667
cn239
Gbatm1.1Pmis/Gbatm1.1Pmis
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4867688
cn240
Septin9tm2.1Emfu/Septin9tm2.1Emfu
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5544265
cn241
Hivep3tm1Glm/Hivep3tm1Glm
Nfatc1tm3Glm/Nfatc1tm3Glm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5550521
cn242
Tg(JAK2*V617F)FF1Rsko/0
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5553472
cn243
Ccna2tm1.1Pisc/Ccna2tm1.1Pisc
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4461993
cn244
Nrastm1Tyj/Nrastm2.1Tyj
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5563458
cn245
Nrastm1Tyj/Nrastm1Tyj
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5563459
cn246
Gt(ROSA)26Sortm1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4443118
cn247
Srrttm1.1Thsn/Srrttm1.2Thsn
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:4360118
cn248
Rfktm1.1Jcbr/Rfktm1.1Jcbr
Tg(Mx1-cre)1Cgn/?
involves: C57BL/6 * CBA MGI:4356077
cn249
Mecomtm1Miku/Mecomtm1Miku
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3849428
cn250
Fn1tm1.1Sakai/Fn1tm1.1Sakai
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5604401
cn251
Nfatc1tm3Glm/Nfatc1tm3Glm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3831753
cn252
Runx1tm3Dow/Runx1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3814543
cn253
Racgap1tm1Mahi/Racgap1tm1Mahi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3804500
cn254
Plcg2tm1Kuro/Plcg2tm1Kuro
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3777293
cn255
Cd79atm3Cgn/Cd79atm3Cgn
Tg(Mx1-cre)1Cgn/?
involves: C57BL/6 * CBA MGI:3716167
cn256
Atmintm1.2Jhh/Atmintm1.2Jhh
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5463971
cn257
Ccnd3tm2.1Pisc/Ccnd3tm2.1Pisc
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5468354
cn258
Jak2tm1Mohi/Jak2tm1Mohi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5320791
cn259
Jak2tm1Mohi/Jak2+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5320790
cn260
Tet2tm1Ics/Tet2tm1Ics
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5141273
cn261
Ccm2tm2.1Sbn/Ccm2tm2.1Sbn
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5085321
cn262
Slc4a2tm2Ges/Slc4a2tm2Ges
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5487549
cn263
Pmltm1(PML/RARA)Ley/Pml+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5014085
cn264
Eef1a1tm2Arge/Eef1a1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5491045
cn265
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5492067
cn266
Hdac1tm1Ics/Hdac1tm1Ics
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5494630
cn267
Npm1tm1Gsva/Npm1+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5004900
cn268
Tg(Mx1-cre)1Cgn/0
Tnfrsf13ctm2.1Mass/Tnfrsf13ctm2.1Mass
involves: C57BL/6 * CBA MGI:4949664
cn269
Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sor+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5502779
cn270
Gt(ROSA)26Sortm1(CAG-NPM1*)Geno/Gt(ROSA)26Sortm1(CAG-NPM1*)Geno
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:5502780
cn271
Atg7tm1Tchi/Atg7tm1Tchi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3590137
cn272
Spi1tm1.2Nutt/Spi1tm1.2Nutt
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3578821
cn273
Tg(Mx1-cre)1Cgn/0
Traf2tm1Rbr/Traf2tm1Rbr
involves: C57BL/6 * CBA MGI:3511504
cn274
Mettm2Cbm/Mettm2.1Cbm
Tg(Mx1-cre)1Cgn/?
involves: C57BL/6 * CBA MGI:3050982
cn275
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Mx1-cre)1Cgn/?
involves: C57BL/6 * CBA MGI:3045467
cn276
Mapk7tm1Jdl/Mapk7tm1Jdl
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3042041
cn277
Runx1tm1Soga/Runx1tm1.1Soga
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3036555
cn278
Rce1tm2Kim/Rce1tm2Kim
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:3032513
cn279
Notch2tm2Hhi/Notch2tm1.1Hhi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:2663720
cn280
Tal1tm2Sho/Tal1tm2Sho
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:2661473
cn281
Rag2tm1Cgn/Rag2tm1.1Cgn
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA MGI:2654913
cn282
Stat3tm1Vpo/Stat3tm2Vpo
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * BALB/cAn MGI:3040651
cn283
Gna13tm2.1Soff/Gna13tm2.1Soff
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * FVB/N MGI:3699351
cn284
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA/J MGI:5688862
cn285
Prkaa1tm1.1Sjm/Prkaa1tm1.1Sjm
Prkaa2tm1.1Sjm/Prkaa2tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * SJL MGI:4840217
cn286
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * SJL MGI:5639318
cn287
Stk11tm1.1Sjm/Stk11tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * SJL MGI:4840221
cn288
Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6J * C57BL/6N * CBA/J MGI:6267346
cn289
Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6J * C57BL/6N * CBA/J MGI:6267347
cn290
Abcb10tm1.1Tafu/Abcb10tm1.2Tafu
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6J * C57BL/6NCrlj * CBA/J * CBA/JNCrlJ MGI:5749139
cn291
Arid3btm1c(KOMP)Wtsi/Arid3btm1c(KOMP)Wtsi
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6J * C57BL/6N * SJL MGI:5819087
cn292
Rps14tm1.1Ble/Rps14+
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6J * C57BL/6NTac * CBA/J MGI:6148308
cn293
Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Mx1-cre)1Cgn/0
Not Specified MGI:5697721
cn294
Col1a1tm1(CAG-Mir22)Ppp/Col1a1tm1(CAG-Mir22)Ppp
Tg(Mx1-cre)1Cgn/0
Not Specified MGI:5527245
cn295
Ccnctm1.1Pisc/Ccnctm1.1Pisc
Tg(Lck-LMO1)11Sjk/0
Tg(Mx1-cre)1Cgn/0
Not Specified MGI:5697722
cx296
Nf1tm1Fcr/Nf1+
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
B6.Cg-Tg(Mx1-cre)1Cgn Nf1tm1Fcr Ptentm1Hwu MGI:5787929
cx297
Tg(Mx1-cre)1Cgn/0
Tg(Tal1-tTA)19Dgt/0
Tg(tetO-BCR/ABL1)2Dgt/0
TgTn(pb-sb-GrOnc)#aGsva/0
involves: C57BL/6 * CBA/J * DBA/2 * FVB/N MGI:5806784


Genotype
MGI:5294434
cn1
Allelic
Composition
Cdkn1atm1Led/Cdkn1atm1Led
Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Led mutation (1 available); any Cdkn1a mutation (52 available)
Cdkn1ctm2.1Kei mutation (1 available); any Cdkn1c mutation (9 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• when Cdkn1ctm2.1Kei is inherited maternally, hematopoietic stem (KSL) cells from pIpC-treated mice exhibit reduced colony formation in vitro before and after coculture with OP9 cells compared with control cells




Genotype
MGI:5294433
cn2
Allelic
Composition
Cdkn1ctm2.1Kei/Cdkn1c+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Cdkn1ctm2.1Kei Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm2.1Kei mutation (1 available); any Cdkn1c mutation (9 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• when Cdkn1ctm2.1Kei is inherited maternally, mice exhibit decreased KSL fractions as early as 4 weeks after pIpC-treatment compared with control mice
• when Cdkn1ctm2.1Kei is inherited maternally, hematopoietic stem cells from pIpC-treated mice exhibit decreased self-renewal capacity, decreased maintenance of quiescence, and increased frequency of apoptosis compared with control mice




Genotype
MGI:3828267
cn3
Allelic
Composition
Dll4tm1Frad/Dll4tm1Frad
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Dll4tm1Frad Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm1Frad mutation (0 available); any Dll4 mutation (16 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• when bone marrow is transplanted into CD45.1+ wild-type hosts reconstitution is normal




Genotype
MGI:6286132
cn4
Allelic
Composition
Dnmt3atm1Trow/Dnmt3a+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Dnmt3atm1Trow Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm1Trow mutation (1 available); any Dnmt3a mutation (85 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• 6 months after induction with poly(I:C) (pIpC), multipotent progenitor cell populations increase in percentage and total number in bone marrow

hematopoietic system
• 6 months after induction with poly(I:C) (pIpC), multi-lineage, mixed granulocyte/erythroid/macrophage/megakaryocyte (GEMM) colonies increase in percentage and total number in bone marrow
• 6 months after induction with poly(I:C) (pIpC), viable long term hematopoietic stem cells and short term hematopoietic stem cells increase in percentage and total number in bone marrow




Genotype
MGI:3831698
cn5
Allelic
Composition
F2tm1Jld/F2tm1Jld
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-F2tm1Jld Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (30 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following induction with poly(I:C), mice exhibit reduced clearance of S. aureus compared to wild-type mice




Genotype
MGI:3690550
cn6
Allelic
Composition
Fastm1Cgn/Fastm1Cgn
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Fastm1Cgn Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Cgn mutation (1 available); any Fas mutation (48 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after Poly(I) Poly(C) induction of cre expression mice develop the lymphoproliferative disease seen in Fastm1.1Cgn homozygtes

hematopoietic system




Genotype
MGI:3819966
cn7
Allelic
Composition
Flt3tm1Dosm/Flt3+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Flt3tm1Dosm Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt3tm1Dosm mutation (0 available); any Flt3 mutation (8 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• PIPC treated-mice die between 6 and 20 months of age with a median survival time of 10 months

hematopoietic system
• bone marrow and spleen cells of PIPC treated-mice produce more colony forming units-granulocyte/monocyte (CFU-GM) than in wild-type cultures
• however, the number of burst-forming units-erythroid is normal
• cultured bone marrow and spleen cells of PIPC treated-mice produce more immature cells than wild-type cultures
• transplanted bone marrow cells of PIPC treated-mice are capable of producing bone marrow hypercellularity and splenomegaly in recipients
• in PIPC treated-mice
• B cell maturation in PIPC treated-mice is blocked resulting in decreased pre-B cells and increased pro-B cells compared to in wild-type mice
• in some older PIPC treated-mice
• bone marrow and spleen cells of PIPC treated-mice produce more colony forming units-granulocyte/monocyte (CFU-GM) in culture compared to wild-type cells
• however, the number of burst-forming units-erythroid is normal
• cultured bone marrow and spleen cells of PIPC treated-mice produce more immature cells than wild-type cultures
• at 12 months, bone marrow of PIPC treated-mice becomes hypercellular with accumulation of immature myeloid cells and increased mononuclear cell numbers unlike in wild-type mice
• the fraction of undifferentiated or partially differentiated myeloid cells in PIPC treated-mice is increased compared to in wild-type mice
• at 2 months, megakaryocyte populations in the bone marrow of PIPC treated-mice are reduced compared to in wild-type mice
• at 2 months, erythrocyte populations in the bone marrow of PIPC treated-mice are reduced compared to in wild-type mice
• at 12 months, PIPC treated-mice mice exhibit a decrease in the number of Ter119 cells in the bone marrow
• at 12 months of age but not 2 months of age in PIPC treated-mice
• in the bone marrow and spleen in PIPC treated-mice
• slightly at 2 months of age in PIPC treated-mice
• slightly at 2 months of age in PIPC treated-mice
• slightly at 2 months of age in PIPC treated-mice
• B lymphoid populations in the spleen are reduced compared to in wild-type mice
• at 2 months and 12 months of age, B lymphoid populations in the bone marrow of PIPC treated-mice are reduced compared to in wild-type mice
• in the bone marrow at 12 months of age in PIPC treated-mice
• at 12 months of age in PIPC treated-mice
• granulocyte and monocyte populations of PIPC treated-mice are expanded in the spleen compared to in wild-type mice
• at 2 months, granulocyte populations in the bone marrow of PIPC treated-mice are expanded compared to in wild-type mice
• at 12 months, the bone marrow of PIPC treated-mice contains more Gr-1 cells than in wild-type mice
• at 12 months of age in PIPC treated-mice
• granulocyte and monocyte populations from PIPC treated-mice are expanded in the spleen compared to in wild-type mice
• at 2 months, monocyte populations in the bone marrow of PIPC treated-mice are expanded compared to in wild-type mice
• at 12 months, the bone marrow of PIPC treated-mice contains more Mac-1 cells than in wild-type mice
• the number of Lin-/low and/or c-KIT+ cells in the bone marrow of PIPC treated-mice is increased at 2 months of age, and even more so at 12 months of age, compared to in wild-type mice
• spleen size in PIPC treated-mice is 2.5-fold greater than normal at 2 months of age and 5-fold greater at 12 months of age
• white pulp in PIPC treated-mice contains more immature myeloid less and fewer mature lymphocytes than in wild-type mice
• at 2 months, areas of myeloproliferation in PIPC treated-mice are found within the red pulp unlike in wild-type mice
• at 12 months, PIPC treated-mice mice exhibit progressive myeloproliferation with expansion mostly of immature myeloid cells in the red pulp unlike in wild-type mice

cellular
• bone marrow cells of PIPC treated-mice can be cultured for longer than wild-type cells without immortalization and with reduced requirement of cytokines

immune system
• in PIPC treated-mice
• B cell maturation in PIPC treated-mice is blocked resulting in decreased pre-B cells and increased pro-B cells compared to in wild-type mice
• in the bone marrow and spleen in PIPC treated-mice
• slightly at 2 months of age in PIPC treated-mice
• slightly at 2 months of age in PIPC treated-mice
• slightly at 2 months of age in PIPC treated-mice
• B lymphoid populations in the spleen are reduced compared to in wild-type mice
• at 2 months and 12 months of age, B lymphoid populations in the bone marrow of PIPC treated-mice are reduced compared to in wild-type mice
• in the bone marrow at 12 months of age in PIPC treated-mice
• at 12 months of age in PIPC treated-mice
• granulocyte and monocyte populations of PIPC treated-mice are expanded in the spleen compared to in wild-type mice
• at 2 months, granulocyte populations in the bone marrow of PIPC treated-mice are expanded compared to in wild-type mice
• at 12 months, the bone marrow of PIPC treated-mice contains more Gr-1 cells than in wild-type mice
• at 12 months of age in PIPC treated-mice
• granulocyte and monocyte populations from PIPC treated-mice are expanded in the spleen compared to in wild-type mice
• at 2 months, monocyte populations in the bone marrow of PIPC treated-mice are expanded compared to in wild-type mice
• at 12 months, the bone marrow of PIPC treated-mice contains more Mac-1 cells than in wild-type mice
• spleen size in PIPC treated-mice is 2.5-fold greater than normal at 2 months of age and 5-fold greater at 12 months of age
• white pulp in PIPC treated-mice contains more immature myeloid less and fewer mature lymphocytes than in wild-type mice
• at 2 months, areas of myeloproliferation in PIPC treated-mice are found within the red pulp unlike in wild-type mice
• at 12 months, PIPC treated-mice mice exhibit progressive myeloproliferation with expansion mostly of immature myeloid cells in the red pulp unlike in wild-type mice




Genotype
MGI:4848041
cn8
Allelic
Composition
Fth1tm1.1Lck/Fth1tm1.1Lck
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fth1tm1.1Lck mutation (1 available); any Fth1 mutation (4 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice fed a high iron diet and treated with pIpC

homeostasis/metabolism
• in mice fed a high iron diet and treated with pIpC
• in mice fed a high iron diet and treated with pIpC
• mice fed a high iron diet and treated with pIpC exhibit liver damage (including increased liver weight, swollen liver, enlarged nuclei, macrosteatosis, hemorrhage, infiltration of polymorphonuclear cells, hepatocyte apoptosis, and decreased liver function) and increased lethality compared with Fth1tm1.1Lck homozygotes fed a high iron diet
• pIpC-treated mice injected with iron-dextran exhibit acute liver damage unlike iron-dextran-treated Fth1tm1.1Lck homozygotes
• however, no liver damage is observed in pIpC treated mice fed standard chow
• in reticuloendothelial cells of pIpC-treated mice
• mild in pIpC-treated mice

liver/biliary system
• in mice fed a high iron diet and treated with pIpC
• mice fed a high iron diet and treated with pIpC exhibit swollen livers with infiltration of polymorphonuclear cells unlike in Fth1tm1.1Lck homozygotes fed a high iron diet
• in mice fed a high iron diet and treated with pIpC
• macrosteatosis in mice fed a high iron diet and treated with pIpC

immune system
• in reticuloendothelial cells of pIpC-treated mice
• mice fed a high iron diet and treated with pIpC exhibit swollen livers with infiltration of polymorphonuclear cells unlike in Fth1tm1.1Lck homozygotes fed a high iron diet

cardiovascular system
• in mice fed a high iron diet and treated with pIpC

hematopoietic system
• in reticuloendothelial cells of pIpC-treated mice




Genotype
MGI:6286136
cn9
Allelic
Composition
Dnmt3atm1Trow/Dnmt3a+
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sor+
Npm1tm1Trow/Npm1+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj Npm1tm1Trow Dnmt3atm1Trow Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm1Trow mutation (1 available); any Dnmt3a mutation (85 available)
Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj mutation (2 available); any Gt(ROSA)26Sor mutation (503 available)
Npm1tm1Trow mutation (1 available); any Npm1 mutation (23 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• bone marrow cells transplanted into lethally irradiated recipients and treated with pIpC and tamoxifen results in death in a 100% of animals in a 440 day period
• in 33% of mice death is the result of myeloproliferative disorder (MPD)
• in 67% of mice death is the result of mixed myelodysplastic syndrome and myeloproliferative disorder (MDS/MPD)
• bone marrow cells from MDS/MPD or MPD primary transplants transplanted into sublethally irradiated secondary recipients results in 100% lethality due to acute myeloid leukemia (AML)




Genotype
MGI:3830385
cn10
Allelic
Composition
Inpp5dtm1Wgk/Inpp5dtm1.1Wgk
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Inpp5dtm1Wgk/Inpp5dtm1.1Wgk Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1.1Wgk mutation (1 available); any Inpp5d mutation (39 available)
Inpp5dtm1Wgk mutation (1 available); any Inpp5d mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Cd11b+Gr+ myeloid suppressor cell (MySC) numbers are significantly increased in both the spleen and mesenteric lymph nodes after cre induction
• expansion is 5- to 10-fold higher than controls in the spleen and 10- to 20- fold higher in the lymph nodes after cre induction
• when cre expression is only partially induced, significant increase in MySC numbers are still observed
• Cd11b +Gr+ myeloid suppressor cell (MySC) have an enhanced ability on a per cell basis to suppress allogenic T cells in a mixed lymphocyte reaction
• priming of allogenic T cells by mutant splenocytes is also poor, an effect attributable to the enhanced MySC activity

hematopoietic system
• Cd11b+Gr+ myeloid suppressor cell (MySC) numbers are significantly increased in both the spleen and mesenteric lymph nodes after cre induction
• expansion is 5- to 10-fold higher than controls in the spleen and 10- to 20- fold higher in the lymph nodes after cre induction
• when cre expression is only partially induced, significant increase in MySC numbers are still observed
• Cd11b +Gr+ myeloid suppressor cell (MySC) have an enhanced ability on a per cell basis to suppress allogenic T cells in a mixed lymphocyte reaction
• priming of allogenic T cells by mutant splenocytes is also poor, an effect attributable to the enhanced MySC activity




Genotype
MGI:3830386
cn11
Allelic
Composition
Inpp5dtm1Wgk/Inpp5dtm1Wgk
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Inpp5dtm1Wgk Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1Wgk mutation (1 available); any Inpp5d mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in mice in which cre expression is induced, there is a 94% survival rate in irradiated mutant mice receiving wild-type BALB/c bone marrow compared to controls that only had a 57% survival rate
• these mice also have higher weights and have fewer manifestations of GVHD including better skin texture, less fur loss, and more activity
• donor bone marrow engraftment occurred in the mutant mice suggesting the allogenic immune cells present in the mice were being suppressed




Genotype
MGI:4936844
cn12
Allelic
Composition
Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Rb1cc1tm1.1Guan Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1cc1tm1.1Guan mutation (0 available); any Rb1cc1 mutation (5 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fetal hemoatopoietic stem cells (HSC) are unable to reconstitute lethally irradiated recipients after pIpC treatment to induce cre expression, indicating cell-autonomous requirement for maintanance and function of fetal HSCs




Genotype
MGI:5448842
cn13
Allelic
Composition
Rictortm1.1Klg/Rictortm1.1Klg
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Rictortm1.1Klg Tg(Mx1-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rictortm1.1Klg mutation (2 available); any Rictor mutation (17 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• cell-intrinsic reduction of DN3 and DN4 thymocyte proliferation without an increase in apoptosis

immune system
N
• mice exhibit the normal frequency of mature T cells
• cell-intrinsic reduction of DN3 and DN4 thymocyte proliferation without an increase in apoptosis
• the percentage of DN3 is increased while the percentage of DN1 and DN4 cells is reduced
• of mature T cells in the thymus

hematopoietic system
N
• mice exhibit normal adult hematopoiesis
• cell-intrinsic reduction of DN3 and DN4 thymocyte proliferation without an increase in apoptosis
• the percentage of DN3 is increased while the percentage of DN1 and DN4 cells is reduced
• of mature T cells in the thymus

endocrine/exocrine glands




Genotype
MGI:5787932
cn14
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
Genetic
Background
B6.Cg-Tg(Mx1-cre)1Cgn Ptentm1Hwu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of poly(I:C) injected mice at P8 is 35 days

hematopoietic system
• mice injected with poly(I:C) at P8 exhibit anemia 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show an elevation in granulocytes 2-3 weeks post induction
• mice injected with poly(I:C) at P8 exhibit increased platelets 2-3 weeks post induction, although the level of platelet increase in smaller than in mice also heterozygous for Nf1tm1Fcr
• mice injected with poly(I:C) at P8 show a reduction in lymphocytes 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show decreased B-cell (CD19+) populations in PB and spleen at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show decreased T-cell (CD3e+) populations in PB and spleen at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show substantial macrophage infiltration in the spleens, livers, and lungs at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show an elevation in monocytes in the spleens, livers, and lungs at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 exhibit increased spleen size
• mice injected with poly(I:C) at P8 exhibit increased spleen weight

immune system
• mice injected with poly(I:C) at P8 show an elevation in granulocytes 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show a reduction in lymphocytes 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show decreased B-cell (CD19+) populations in PB and spleen at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show decreased T-cell (CD3e+) populations in PB and spleen at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show substantial macrophage infiltration in the spleens, livers, and lungs at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 show an elevation in monocytes in the spleens, livers, and lungs at 2-3 weeks post induction
• mice injected with poly(I:C) at P8 exhibit increased spleen size
• mice injected with poly(I:C) at P8 exhibit increased spleen weight

liver/biliary system
• mice injected with poly(I:C) at P8 exhibit increased liver size
• mice injected with poly(I:C) at P8 exhibit increased liver weight

neoplasm
• mice injected with poly(I:C) at 6 weeks of age develop a transient myeloproliferative neoplasm after 3 weeks post induction and 5/7 transform to T-ALL
• mice injected with poly(I:C) at 6 weeks of age develop a transient myeloproliferative neoplasm after 3 weeks post induction and 5/7 transform to T-ALL




Genotype
MGI:5695364
cn15
Allelic
Composition
Srsf2tm1.1Oaw/Srsf2+
Tg(Mx1-cre)1Cgn/?
Genetic
Background
B6.Cg-Tg(Mx1-cre)1Cgn Srsf2tm1.1Oaw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srsf2tm1.1Oaw mutation (1 available); any Srsf2 mutation (2 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• percentage of LSK cells is decreased in G1 and increased in S as compared to controls
• increase in the proportion of apoptotic hematopoietic stem (LSK) cells

hematopoietic system
• erythroid dysplasia
• decrease in intermediate myeloid progenitors (pre-MEGE, pre-CFUE)
• myeloid dysplasia
• appearance of nuclear irregularities and cytoplasmic vacuolization and blebbing of erythroid precursors
• appearance of hypolobated and hypogranulated neutrophils
• decreased numbers of B cells in peripheral blood at all stages beginning at pro-B cell number
• increase in splenic LSK cells 14 weeks after pIpC injection although splenomegaly is not observed
• leukopenia is observed in bone marrow of lethally irradiated recipient mice 18 weeks post-transplantation (pIpC injection 4 weeks after transplantation)
• anemia is observed 18 weeks post-bone marrow transplantation (pIpC injection 4 weeks after transplantation)
• mean corpuscular volume (MCV) is increased in donor bone marrow post-transplantation
• hemoglobin is decreased in donor bone marrow post-transplantation
• increase in total hematopoietic stem cell (LSK) cell number in non-competitive bone marrow transplantation assay 14 weeks after pIpC injection relative to controls
• increase in restricted hematopoietic progenitor cells (LSK, CD48+, CD150+) in bone marrow transplantation assay 14 weeks after pIpC injection relative to controls increase in restricted hematopoietic progenitor cells (LSK, CD48+, CD150+) in bone marrow transplantation assay 14 weeks after pIpC injection relative to controls increase in restricted hematopoietic progenitor cells (LSK, CD48+, CD150+) in bone marrow transplantation assay 14 weeks after pIpC injection relative to controls
• increase in total LSK cell number in bone marrow in competitive bone marrow transplantation assay 14 weeks post-pIpC injection
• increase in proportion of apoptotic hematopoietic stem (LSK) cells
• percentage of LSK cells is decreased in G1 and increased in S as compared to controls

immune system
• decrease in intermediate myeloid progenitors (pre-MEGE, pre-CFUE)
• myeloid dysplasia
• appearance of hypolobated and hypogranulated neutrophils
• decreased numbers of B cells in peripheral blood at all stages beginning at pro-B cell number

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myelodysplastic syndrome DOID:0050908 OMIM:614286
J:221404




Genotype
MGI:4839500
cn16
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0
Genetic
Background
BKS.Cg-Ptprcb Thy1a Tg(Mx1-cre)1Cgn Ptentm1Hwu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (39 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants become ill shortly after pIpC treatment and exhibit lethargy, ruffling of fur, and hunched posture and die from leukemia

hematopoietic system
• mice treated with pIpC to induce Cre expression exhibit an enlarged thymus
• increase in blast cell frequency after pIpC administration to induce Cre expression
• mice treated with polyinosine-polycytidine (pIpC) to induce Cre expression exhibit extramedullary hematopoiesis, with prominent expansion in the number of immature myeloid cells
• mice develop myeloproliferative disease shortly after pIpC administration to induce Cre expression with complete effacement of the splenic architecture
• reduction in bone marrow cellularity after pIpC administration to induce Cre expression
• 10-fold increase in spleen cellularity after pIpC administration to induce Cre expression
• mice treated with pIpC to induce Cre expression exhibit an increase in hematopoietic stem cell proliferation but become depleted, most likely due to inhibition of self-renewal as no increase in cell death was observed
• mutants maintained on rapamycin after pIpC treatment do not exhibit expansion of hematopoietic stem cells

immune system
• mice treated with pIpC to induce Cre expression exhibit an enlarged thymus
• 10-fold increase in spleen cellularity after pIpC administration to induce Cre expression

neoplasm
• within 4-6 weeks after pIpC treatment, most mutants progress to leukemia, including acute myeloid leukemia and acute lymphoblastic leukemia
• mutants maintained on rapamycin after pIpC treatment do not develop leukemia
• seen in mutants within 4-6 weeks after pIpC treatment
• seen in mutants within 4-6 weeks after pIpC treatment

endocrine/exocrine glands
• mice treated with pIpC to induce Cre expression exhibit an enlarged thymus




Genotype
MGI:3758714
cn17
Allelic
Composition
Notch1tm1Agt/Notch1tm1Agt
Notch2tm1Frad/Notch2tm1Frad
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation (0 available); any Notch1 mutation (32 available)
Notch2tm1Frad mutation (0 available); any Notch2 mutation (10 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• irradiated wild-type mice reconstituted with Notch1/2-null bone marrow progenitors analyzed at 8 weeks show block at earliest intrathymic precursor stage; immature B cells develop in the thymus recapitulating the Notch1-null phenotype
• cultured double-null hematopoietic stem cells, HSCs do not develop into T cell progenitors after 10 days
• cultured double null HSCs display a block at the double negative 1 stage

immune system
• irradiated wild-type mice reconstituted with Notch1/2-null bone marrow progenitors analyzed at 8 weeks show block at earliest intrathymic precursor stage; immature B cells develop in the thymus recapitulating the Notch1-null phenotype
• cultured double-null hematopoietic stem cells, HSCs do not develop into T cell progenitors after 10 days
• cultured double null HSCs display a block at the double negative 1 stage




Genotype
MGI:3772194
cn18
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Rnf2tm1Mvi/Rnf2tm1Mvi
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (51 available)
Rnf2tm1Mvi mutation (0 available); any Rnf2 mutation (21 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at 11 weeks after treatment with pIpC with splenomegalia and hepatomegalia

hematopoietic system
N
• the deficits in splenocytes, bone marrow cells and pre-B cells observed in Rnf2tm1Mvi/Rnf2tm1Mvi Tg(Mx1-cre)1Cgn mice treated with pIpC at 6 to 12 weeks is not observed
• following treatment with pIpC at 6 to 12 weeks, mice exhibit an increase in myeloid colony forming units relative to wild-type mice

neoplasm
• following treatment with pIpC, mice develop lymphomas at an earlier age of onset compared to in Cdkn2atm1Rdp homozygotes

liver/biliary system

immune system




Genotype
MGI:3806622
cn19
Allelic
Composition
Atg7tm1Tchi/Atg7tm1Tchi
Sqstm1tm1Keta/Sqstm1tm1Keta
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7tm1Tchi mutation (1 available); any Atg7 mutation (30 available)
Sqstm1tm1Keta mutation (0 available); any Sqstm1 mutation (22 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• slightly eleveated levels of ALT are found in the sera after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles
• high levels of ALP are found in the sera after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles
• slightly elevated levels of AST are found in the sera after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles

liver/biliary system
• the cytoplasmic inclusion bodies containing ubiquitinated proteins that are associated with Atg7 conditional liver knockout mice are almost completely absent in these mice
• liver function is slightly decreased after Cre-induction but not to the degree of conditional knockouts with wild-type Sqstm1 alleles




Genotype
MGI:5524225
cn20
Allelic
Composition
Fbxw7tm1Iaai/Fbxw7tm1Iaai
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iaai mutation (1 available); any Fbxw7 mutation (38 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• pIpC-treated mice exhibit depletion of early T cell progenitors in the thymus
• in the bone marrow of pIpC-treated mice
• less functionally competent than in cells from pIpC-treated mice Fbxw7tm2Iaai/Fbxw7+ Tg(Mx1-cre)1Cgn mice

immune system
• pIpC-treated mice exhibit depletion of early T cell progenitors in the thymus




Genotype
MGI:5515309
cn21
Allelic
Composition
Bcl11atm1Pwt/Bcl11atm1Pwt
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Pwt mutation (0 available); any Bcl11a mutation (5 available)
Kdm1atm1.1Sho mutation (1 available); any Kdm1a mutation (15 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5490966
cn22
Allelic
Composition
Rgs12tm1.1Syy/Rgs12tm1.1Syy
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs12tm1.1Syy mutation (0 available); any Rgs12 mutation (7 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• few osteoclasts are present in the tibia after polyI:C treatment
• however, osteoblast numbers are similar to control
• percentage of bone area to total marrow space in long bones is 1.9 fold that of controls
• following polyI:C treatment
• decreased trabecular spacing in the tibia after polyI:C treatment
• following polyI:C treatment
• abundance of bone and cartilage trabeculae following polyI:C treatment
• following polyI:C treatment
• following polyI:C treatment
• following polyI:C treatment

immune system
• few osteoclasts are present in the tibia after polyI:C treatment
• however, osteoblast numbers are similar to control

hematopoietic system
• few osteoclasts are present in the tibia after polyI:C treatment
• however, osteoblast numbers are similar to control




Genotype
MGI:2680169
cn23
Allelic
Composition
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr1tm1.1Karl mutation (1 available); any Tgfbr1 mutation (8 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• normal hematopoiesis and hematopoietic stem cell self renewal and regenerative ability in spite of an increased hematopoietic stem cell proliferative capacity observed in vitro
• hematopoietic stem cells from polyIC-induced mice show increased proliferation recruitment when cultured as single cells under low stimulatory conditions in vitro

cellular
• hematopoietic stem cells from polyIC-induced mice show increased proliferation recruitment when cultured as single cells under low stimulatory conditions in vitro




Genotype
MGI:3578403
cn24
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation (0 available); any Jag1 mutation (8 available)
Notch1tm1Agt mutation (0 available); any Notch1 mutation (32 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• homozygous mutant mice exhibit normal hematopoiesis, including normal hematopoietic stem cell self-renewal and differentiation




Genotype
MGI:3578401
cn25
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag1tm1Frad mutation (0 available); any Jag1 mutation (8 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• homozygous mutant mice exhibit normal hematopoiesis, including normal hematopoietic stem cell self-renewal and differentiation




Genotype
MGI:3618356
cn26
Allelic
Composition
Mtf1tm2Wsc/Mtf1tm2Wsc
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtf1tm2Wsc mutation (0 available); any Mtf1 mutation (13 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• many cadmium induced changes in liver gene expression seen in controls are not seen in mutants




Genotype
MGI:5468652
cn27
Allelic
Composition
Ccnd3tm1Pisc/Ccnd3tm1Pisc
Rb1tm2Brn/Rb1tm2Brn
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd3tm1Pisc mutation (0 available); any Ccnd3 mutation (536 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (80 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• of pre-T cells as in Ccnd3tm1Pisc homozygotes

immune system
• of pre-T cells as in Ccnd3tm1Pisc homozygotes
• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
• as in Ccnd3tm1Pisc homozygotes

hematopoietic system
• of pre-T cells as in Ccnd3tm1Pisc homozygotes
• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes
• as in Ccnd3tm1Pisc homozygotes

endocrine/exocrine glands
• not as severe as in pIpC-treated mice as in Ccnd3tm1Pisc homozygotes




Genotype
MGI:2448711
cn28
Allelic
Composition
Notch1tm1Agt/Notch1tm1Agt
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Agt mutation (0 available); any Notch1 mutation (32 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mutants injected with interferon-alpha at days 3, 6, 9, and 11 after birth to induce partial gene disruption die for unknown reasons

growth/size/body
• mutants injected with interferon-alpha to induce partial gene disruption show reduced body weight after two weeks post injection
• mutants injected with interferon-alpha to induce partial gene disruption show transient growth retardation

immune system
• thymus architecture is abnormal in mutants injected with interferon-alpha to induce partial gene disruption, such that medullary and cortical regions cannot be distinguished thymic dentritic cells are reduced
• mutants injected with interferon-alpha exhibit an accumulation of B cells in the thymus that differ from normally occurring thymic B cells and resemble immature B cells normally found in the bone marrow (J:55400)
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in Dll4tm1Frad homozygous control mice (J:143472)
• mutants injected with interferon-alpha to induce partial gene disruption have a small thymus
• mutants injected with interferon-alpha to induce partial gene disruption show a 5-fold reduction in thymocyte number
• hematopoietic stem cells do not develop in to B cells after 18 days in culture
• the absolute numbers of immature B cells in the thymus are increased 30-fold compared to in Dll4tm1Frad homozygous control mice
• mutants injected with interferon-alpha to induce partial gene disruption show abnormal T cell maturation and show a block at or before the most immature T cell stage, as most triple-negative (CD4-CD8-TCR-) thymoctyes are CD44+CD25- (J:55400)
• irradiated wild-type mice reconstituted with Notch1-null bone marrow progenitors analyzed at 8 weeks show block at earliest intrathymic precursor stage; immature B cells develop in the thymus (J:125373)
• >90% of Notch1-null HSCs cultured on stromal cells for 28 days are blocked in the double negative compartment and do not progress from double negative to double positive (J:125373)
• TCRgamma/delta+ double-negative thymocytes from mutants injected with interferon-alpha are decreased 10-fold
• thymocytes from mutants injected with interferon-alpha show a 9-fold reduction in double-positive cells
• thymocytes from mutants injected with interferon-alpha show a 5-fold reduction in CD4+ single-positive cells
• thymocytes from mutants injected with interferon-alpha show a 4.4-fold reduction in CD8+ single-positive cells
• immature single-positive thymocytes from mutants injected with interferon-alpha are decreased 13-fold

hematopoietic system
N
• mutants exhibit normal hematopoietic stem cell self-renewal and differentiation
• thymus architecture is abnormal in mutants injected with interferon-alpha to induce partial gene disruption, such that medullary and cortical regions cannot be distinguished thymic dentritic cells are reduced
• mutants injected with interferon-alpha exhibit an accumulation of B cells in the thymus that differ from normally occurring thymic B cells and resemble immature B cells normally found in the bone marrow (J:55400)
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in Dll4tm1Frad homozygous control mice (J:143472)
• mutants injected with interferon-alpha to induce partial gene disruption have a small thymus
• mutants injected with interferon-alpha to induce partial gene disruption show a 5-fold reduction in thymocyte number
• hematopoietic stem cells do not develop in to B cells after 18 days in culture
• the absolute numbers of immature B cells in the thymus are increased 30-fold compared to in Dll4tm1Frad homozygous control mice
• mutants injected with interferon-alpha to induce partial gene disruption show abnormal T cell maturation and show a block at or before the most immature T cell stage, as most triple-negative (CD4-CD8-TCR-) thymoctyes are CD44+CD25- (J:55400)
• irradiated wild-type mice reconstituted with Notch1-null bone marrow progenitors analyzed at 8 weeks show block at earliest intrathymic precursor stage; immature B cells develop in the thymus (J:125373)
• >90% of Notch1-null HSCs cultured on stromal cells for 28 days are blocked in the double negative compartment and do not progress from double negative to double positive (J:125373)
• TCRgamma/delta+ double-negative thymocytes from mutants injected with interferon-alpha are decreased 10-fold
• thymocytes from mutants injected with interferon-alpha show a 9-fold reduction in double-positive cells
• thymocytes from mutants injected with interferon-alpha show a 5-fold reduction in CD4+ single-positive cells
• thymocytes from mutants injected with interferon-alpha show a 4.4-fold reduction in CD8+ single-positive cells
• immature single-positive thymocytes from mutants injected with interferon-alpha are decreased 13-fold

endocrine/exocrine glands
• thymus architecture is abnormal in mutants injected with interferon-alpha to induce partial gene disruption, such that medullary and cortical regions cannot be distinguished thymic dentritic cells are reduced
• mutants injected with interferon-alpha exhibit an accumulation of B cells in the thymus that differ from normally occurring thymic B cells and resemble immature B cells normally found in the bone marrow (J:55400)
• more thymic B cells are present than in control mice and they exhibit varying expression levels of IgM and B220 unlike in Dll4tm1Frad homozygous control mice (J:143472)
• mutants injected with interferon-alpha to induce partial gene disruption have a small thymus
• mutants injected with interferon-alpha to induce partial gene disruption show a 5-fold reduction in thymocyte number




Genotype
MGI:5525154
cn29
Allelic
Composition
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129 * C57BL/6 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm1atm1.1Sho mutation (1 available); any Kdm1a mutation (15 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die 7-10 days after final dose of the immunostimulant dsRNA poly(I:C) as compared to controls
• lethality is a result severe anemia

hematopoietic system
• hematopoietic stem and progenitor cell populations are distorted following final dose of poly(I:C)
• increase in numbers of bipotential granulocytic/moncytic precursor cells following final dose of poly(I:C)
• accumulation of immature myeloid cells
• decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+) after final dose of poly(I:C)
• Gr1high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)
• loss of mature neutrophils following final dose of poly(I:C)
• decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+) 1 week after final dose of poly(I:C)
• following final dose of poly(I:C)
• four fold increase in long term repopulating hematopoietic stem cell (LT-HSC) population (lin- CD150+ CD48- Sca-1+ c-Kit+) found in recombined cells
• immunophenotypic LT-HSC population exhibits 2-fold proliferation, but unaltered apoptosis levels

immune system
• Gr1high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)
• loss of mature neutrophils following final dose of poly(I:C)




Genotype
MGI:5009036
cn30
Allelic
Composition
Ncstntm1.1Akli/Ncstntm1.1Akli
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Akli mutation (0 available); any Ncstn mutation (4 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• do not survive more than 20 weeks after induction of cre mediated recombination

hematopoietic system
• significant reduction of the lymphoid-biased multipotential progenitor population (L-MPP) after induction of cre mediated recombination
• striking increase in the absolute numbers of both bone marrow and spleen granulocyte/monocyte progenitors cells after induction of cre mediated recombination
• decrease of the megakaryocyte?erythrocyte progenitor population after induction of cre mediated recombination
• progenitor cells display an increase in their self-renewal capacity after induction of cre mediated recombination
• striking peripheral blood leukocytosis after induction of cre mediated recombination
• striking peripheral blood monocytosis after induction of cre mediated recombination
• increase in monocyte numbers in the bone marrow and liver after induction of cre mediated recombination
• de-repression of an extended myeloid-specific program in LSK cells
• increase in LSK numbers after induction of cre mediated recombination
• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells after induction of cre mediated recombination
• expansion of the red pulp after induction of cre mediated recombination
• after induction of cre mediated recombination

neoplasm
• similarity to chronic myelomonocytic leukemia after induction of cre mediated recombination

immune system
• striking peripheral blood leukocytosis after induction of cre mediated recombination
• striking peripheral blood monocytosis after induction of cre mediated recombination
• increase in monocyte numbers in the bone marrow and liver after induction of cre mediated recombination
• expansion of the red pulp with diffuse infiltration by myeloid and monocytic cells after induction of cre mediated recombination
• expansion of the red pulp after induction of cre mediated recombination
• after induction of cre mediated recombination

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:172442




Genotype
MGI:5708137
cn31
Allelic
Composition
Mllt10tm1Saam/Mllt10tm1Saam
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mllt10tm1Saam mutation (0 available); any Mllt10 mutation (73 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• abnormal histone methylation and reversal of leukemia-associated epigenetic profiles




Genotype
MGI:5427983
cn32
Allelic
Composition
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx36tm1.2Pmt mutation (1 available); any Dhx36 mutation (3 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in competitive repopulation assays, mice transplanted with bone marrow from pIpC-treated mice exhibit impaired erythropoiesis compared with mice transplanted with control bone marrow
• in competitive repopulation assays, mice transplanted with bone marrow from pIpC-treated mice exhibit impaired leukopoiesis compared with mice transplanted with control bone marrow

immune system
• in competitive repopulation assays, mice transplanted with bone marrow from pIpC-treated mice exhibit impaired leukopoiesis compared with mice transplanted with control bone marrow




Genotype
MGI:3608663
cn33
Allelic
Composition
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1tm1Thsn mutation (2 available); any Bak1 mutation (16 available)
Baxtm1Sjk mutation (1 available); any Bax mutation (25 available)
Baxtm2Sjk mutation (1 available); any Bax mutation (25 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 35 weeks after induction of Cre expression (and thus Bax deletion) in the adult, 78% of mutants die compared to 5% of wild-type

immune system
• thymic T cell development is perturbed after poly(I:C) injection
• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult
• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression
• develop autoimmune disease after poly(I:C) injection to induce Bax deletion in the adult
• show elevated serum antinuclear antibodies and anti-dsDNA antibody after 30 weeks of poly(I:C) injection to induce Bax deletion in the adult
• develops after poly(I:C) injection to induce Bax deletion in the adult
• develops after poly(I:C) injection to induce Bax deletion in the adult

hematopoietic system
• thymic T cell development is perturbed after poly(I:C) injection
• accumulation of white blood cells after injection of poly(I:C) to induce Cre expression in adult
• exhibit accumulation of B cells in the spleen and bone marrow 6 weeks after poly(I:C) injection to induce Cre expression

renal/urinary system
• develops after poly(I:C) injection to induce Bax deletion in the adult

skeleton
• develops after poly(I:C) injection to induce Bax deletion in the adult




Genotype
MGI:4460776
cn34
Allelic
Composition
Lrrc17tm1Nik/Lrrc17+
Nf1tm1Par/Nf1tm1Par
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (4 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (22 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (11 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in pIpC-treated mice with the same timing as in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice

immune system
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice

hematopoietic system
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice




Genotype
MGI:3720351
cn35
Allelic
Composition
Pax5tm1Mbu/Pax5tm3Mbu
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax5tm1Mbu mutation (1 available); any Pax5 mutation (19 available)
Pax5tm3Mbu mutation (1 available); any Pax5 mutation (19 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• half of the mature B cells in the spleen are absent
• only a small number of mature B cells are lost upon short-term inactivation of Pax5
• polyinosine-polycystosine (pIpC)-treated mice lack IgD+B220hi cells

hematopoietic system
• half of the mature B cells in the spleen are absent
• only a small number of mature B cells are lost upon short-term inactivation of Pax5
• polyinosine-polycystosine (pIpC)-treated mice lack IgD+B220hi cells




Genotype
MGI:4944270
cn36
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (39 available)
Rps6kb1tm1Gtho mutation (1 available); any Rps6kb1 mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mice injected with pIpC to induce Pten deletion have an enlarged thymus
• mice injected with pIpC to induce Pten deletion have an enlarged spleen

neoplasm
• mice injected with pIpC to induce Pten deletion, develop myeloproliferative disease and T-cell acute lymphoblastic leukemia, but at a slower rate than in single Pten mutants

mortality/aging
• mean survival time of mice injected with pIpC to induce Pten deletion is 46 days

immune system
• mice injected with pIpC to induce Pten deletion have an enlarged thymus
• mice injected with pIpC to induce Pten deletion have an enlarged spleen

endocrine/exocrine glands
• mice injected with pIpC to induce Pten deletion have an enlarged thymus




Genotype
MGI:4460775
cn37
Allelic
Composition
Krastm4Tyj/Kras+
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (6 available); any Kras mutation (35 available)
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (4 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (11 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in pIpC-treated mice similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice

immune system
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice

hematopoietic system
• bone marrow cells from pIpC-treated mice spontaneous form colony forming units-granulocyte and macrophage (CFU-GM) in the absence of cytokines unlike wild-type cells
• in pIpC-treated mice similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice




Genotype
MGI:4839763
cn38
Allelic
Composition
Ago2tm1.1Tara/Ago2tm1.1Tara
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ago2tm1.1Tara mutation (1 available); any Ago2 mutation (37 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells, red blood cells contain Heinz bodies and hemoglobin precipitates unlike in cells from mice reconstituted with untreated bone marrow
• erythroid precursor maturation is severely impaired with erythroid hyperplasia in bone marrow and spleen in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells compared to when untreated bone marrow is used
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells

immune system
• in lethally irradiated mice reconstituted with pIpC-treated bone marrow cells




Genotype
MGI:5009039
cn39
Allelic
Composition
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm2Rko mutation (3 available); any Notch1 mutation (32 available)
Notch2tm1Rko mutation (0 available); any Notch2 mutation (10 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (7 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in the granulocyte/monocyte progenitors cell population
• increase in the granulocyte/monocyte progenitors cell population
• massive invasion of myeloid cells

neoplasm
• similarity to chronic myelomonocytic leukemia

immune system
• massive invasion of myeloid cells




Genotype
MGI:5009045
cn40
Allelic
Composition
Notch1tm2Rko/Notch1tm2Rko
Notch2tm1Rko/Notch2tm1Rko
Notch3Gt(PST033)Byg/Notch3+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm2Rko mutation (3 available); any Notch1 mutation (32 available)
Notch2tm1Rko mutation (0 available); any Notch2 mutation (10 available)
Notch3Gt(PST033)Byg mutation (0 available); any Notch3 mutation (7 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• myeloproliferative disease
• massive invasion of myeloid cells

immune system
• massive invasion of myeloid cells




Genotype
MGI:3040656
cn41
Allelic
Composition
Stat3tm1Vpo/Stat3tm1Vpo
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Vpo mutation (0 available); any Stat3 mutation (36 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type
• increased IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type
• increased TNF production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type

hematopoietic system
• increased TNF and IL-6 production by peritoneal macrophages stimulated by LPS and IFN-gamma, relative to those of wild-type




Genotype
MGI:3700792
cn42
Allelic
Composition
Furintm1Jwmc/Furintm1.1Jwmc
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Furintm1.1Jwmc mutation (0 available); any Furin mutation (4 available)
Furintm1Jwmc mutation (0 available); any Furin mutation (4 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
N
• conditional mice show no liver phenotype




Genotype
MGI:3706809
cn43
Allelic
Composition
Gt(ROSA)26Sortm1(CTNNB1)Nerl/Gt(ROSA)26Sortm1(CTNNB1)Nerl
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CTNNB1)Nerl mutation (0 available); any Gt(ROSA)26Sor mutation (503 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• wheni injected with poly(I:C) to induce cre expression, mutants become moribund and die within 2-3 weeks

immune system
• after cre induction, mutants have ~25% of control cell numbers in thymus
• a block at the DN1-DN2 transition is found
• myeloid cells are almost totally absent in induced mutants
• induced mutants have fewer leukocytes
• the double negative compartment of thymic T cells is relatively decreased relative to CD4 and CD8 double positive and single positive T cells
• after cre induction, mice show a loss of granulocytic cells

hematopoietic system
• after cre induction, mutants have ~25% of control cell numbers in thymus
• a block at the DN1-DN2 transition is found
• myeloid cells are almost totally absent in induced mutants
• after cre induction, mice develop severe anemia
• after cre induction, mutants have ~25% of control bone marrow cell numbers
• bone marrow shows abnormal presence of immature erythroid cells in induced mutants
• peripheral blood from induced mutants is pale and has reduced red blood cell counts
• hemoglobin concentration in peripheral blood of induced mutants is reduced
• platelet count in induced mutants is reduced
• induced mutants have fewer leukocytes
• the double negative compartment of thymic T cells is relatively decreased relative to CD4 and CD8 double positive and single positive T cells
• after cre induction, mice show a loss of granulocytic cells

endocrine/exocrine glands
• after cre induction, mutants have ~25% of control cell numbers in thymus




Genotype
MGI:4460774
cn44
Allelic
Composition
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (4 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (11 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit a normal lifespan and causes of death

neoplasm
N
• MOL4070LTR-induced leukemia is the same as in similarly treated wild-type mice

hematopoietic system
N
• mice exhibit normal blood counts




Genotype
MGI:3831696
cn45
Allelic
Composition
F2tm1Jld/F2tm1Sjd
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2tm1Jld mutation (0 available); any F2 mutation (30 available)
F2tm1Sjd mutation (0 available); any F2 mutation (30 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• following induction with poly(I:C)

cardiovascular system
• following induction with poly(I:C), hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins
• aged uninduced mice develop hemosiderin depositions and cardiac fibrosis unlike wild-type mice
• following induction with poly(I:C), nearly all mice exhibit cardiac hemorrhaging with some hemorrhaging in the pleural cavity (in 46% of mice), intracranial cavity (in 46% of mice), or focally within the skeletal muscle (in 18% of mice) unlike in wild-type mice
• following induction with poly(I:C), hemorrhaging is occasionally observed in the skin, spinal canal, bowels, and testes
• however, without induction with poly(I:C) no hemorrhaging is observed
• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity
• occasionally in the bowels following induction with poly(I:C)
• occasionally in the testes following induction with poly(I:C)
• following induction with poly(I:C), nearly all mice exhibit cardiac hemorrhaging
• following induction with poly(I:C), hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins
• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging
• following induction with poly(I:C), intracranial bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus
• following induction with poly(I:C)
• occasionally in the spinal canal following induction with poly(I:C)
• occasionally in the skin following induction with poly(I:C)
• occasionally following induction with poly(I:C)

homeostasis/metabolism
• clotting time is modestly increased compared to in wild-type mice
• following induction with poly(I:C), clotting time is severely increased compared to in wild-type mice
• however, platelet counts and fibrinogen amounts are normal, and treatment with prothrombin restores normal clotting times
• following induction with poly(I:C)

nervous system
• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging
• following induction with poly(I:C), intracranial bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus
• following induction with poly(I:C)
• occasionally in the spinal canal following induction with poly(I:C)

reproductive system
• occasionally in the testes following induction with poly(I:C)

integument
• occasionally in the skin following induction with poly(I:C)
• occasionally following induction with poly(I:C)

respiratory system
• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

digestive/alimentary system
• occasionally in the bowels following induction with poly(I:C)




Genotype
MGI:5762869
cn46
Allelic
Composition
Ruvbl1tm1.1Oxbk/Ruvbl1tm1.1Oxbk