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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Sycp1-cre)4Min
transgene insertion 4, Minoo Rassoulzadegan
MGI:2176068
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Artm1Chc/Y
Tg(Sycp1-cre)4Min/0
involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3775036
cn2
Thratm1Ffla/Thra+
Tg(Sycp1-cre)4Min/?
involves: 129/Sv * C57BL/6 * DBA/2 MGI:3758926


Genotype
MGI:3775036
cn1
Allelic
Composition
Artm1Chc/Y
Tg(Sycp1-cre)4Min/0
Genetic
Background
involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Chc mutation (0 available); any Ar mutation (20 available)
Tg(Sycp1-cre)4Min mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• sperm counts are similar to those in wild-type males
• males are fertile; meiosis and spermatogenesis are unaffected
• testes are normal in size and morphology; serum testosterone levels are within normal range




Genotype
MGI:3758926
cn2
Allelic
Composition
Thratm1Ffla/Thra+
Tg(Sycp1-cre)4Min/?
Genetic
Background
involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sycp1-cre)4Min mutation (1 available)
Thratm1Ffla mutation (0 available); any Thra mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 48% of mice do not reach adulthood

reproductive system
• despite no obvious defects in ovary morphology, females are sterile

nervous system
• unlike in wild-type mice, at P21 the external granule layer persists and granular precursor cells are still present
• at P15, arborization of Purkinje cell dendrites is reduced by number and size of dendritic spines

behavior/neurological
• mice display an ataxic bearing and spread their hindlimbs to maintain their posture

growth/size/body
• while surviving mice gain weight they suffer from a permanent and disproportioned dwarfism

homeostasis/metabolism
• mice exhibit a defect in thermogenesis such that the body temperature in some mice drops within a few hours after cold exposure

cardiovascular system
• 224+/-24 beats per minute compared to 393+/-45 beats per minute in wild-type mice
• mice sometime display cardiac arrhythmia

skeleton
• ossification of the long bones is delayed

hematopoietic system
• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)

vision/eye
• eyelid opening was delayed to P25 compared to P15 in wild-type mice

immune system
• at P15, spleen weight is decreased (26.9+/-12.2 mg compared to 39.5+/-9.1 mg in wild-type mice)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory