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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Zp3-cre)3Mrt
transgene insertion 3, Gail R Martin
MGI:2176052
Summary 20 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Kmt2btm1Afst/Kmt2btm1.1Afst
Tg(Zp3-cre)3Mrt/0
involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4867494
cn2
Bcas2tm1.1Lil/Bcas2tm1.1Lil
Tg(Zp3-cre)3Mrt/0
involves: 129 * C57BL/6 * FVB/N * SJL MGI:5910025
cn3
Tet3tm1.1Gxu/Tet3tm1.2Gxu
Tg(Zp3-cre)3Mrt/0
involves: 129 * C57BL/6J * FVB/N * SJL MGI:5294568
cn4
Foxn1tm1.1Cbln/Foxn1+
Tg(Zp3-cre)3Mrt/?
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N MGI:5297814
cn5
H19tm6Tilg/H19tm6Tilg
Tg(Zp3-cre)3Mrt/?
involves: 129P2/OlaHsd * C57BL/6 MGI:3714394
cn6
Porcntm1.1Jrt/Porcn+
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N MGI:5523431
cn7
Porcntm1.1Jrt/Y
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N MGI:5523432
cn8
Scn8atm1Mm/Scn8atm1Mm
Tg(Zp3-cre)3Mrt/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3050792
cn9
Zeb1tm2Yhi/Zeb1tm2Yhi
Zeb2tm1.1Yhi/Zeb2tm1.1Yhi
Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR MGI:3653735
cn10
Tfap2ctm1Will/Tfap2ctm2Will
Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * FVB/N MGI:3687951
cn11
Tfap2atm1Hsv/Tfap2atm2Will
Tfap2ctm1Will/Tfap2ctm2Will
Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * FVB/N MGI:3687952
cn12
Tfap2atm2Will/Tfap2a+
Tfap2ctm1Will/Tfap2ctm2Will
Tg(Zp3-cre)3Mrt/0
involves: 129S1/Sv * FVB/N MGI:3687953
cn13
Mybl2tm1.1Jof/Mybl2+
Tg(Zp3-cre)3Mrt/0
involves: 129S2/SvPas * C57BL/6 * FVB/N MGI:5518769
cn14
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Zp3-cre)3Mrt/0
involves: 129S4/SvJae * C57BL/6J * FVB/N MGI:3692538
cn15
Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Zp3-cre)3Mrt/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3698138
cn16
Nlrp3tm1Hhf/Nlrp3+
Tg(Zp3-cre)3Mrt/?
involves: 129/Sv * FVB/N MGI:3850044
cn17
Ndc80tm1Tski/Ndc80tm1Tski
Tg(Zp3-cre)3Mrt/0
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N MGI:6452499
cn18
Ythdf2tm1.1Doca/Ythdf2tm1.1Doca
Tg(Zp3-cre)3Mrt/0
involves: FVB/N MGI:5911743
tg19
Tg(Zp3-cre)3Mrt/Tg(Zp3-cre)3Mrt FVB/N-Tg(Zp3-cre)3Mrt/J MGI:3835424
tg20
Tg(Zp3-cre)3Mrt/0 B6.FVB-Tg(Zp3-cre)3Mrt MGI:3835441


Genotype
MGI:4867494
cn1
Allelic
Composition
Kmt2btm1Afst/Kmt2btm1.1Afst
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2btm1.1Afst mutation (0 available); any Kmt2b mutation (37 available)
Kmt2btm1Afst mutation (0 available); any Kmt2b mutation (37 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• decreased number of primordial follicles at 3 weeks old
• increased number of secondary and preantral follicles at 3 weeks old
• decreased number of primordial follicles and preantral follicles at 8 weeks old
• increased number of atretic follicles at 8 weeks old
• reduced ovulation rates (20%-25% of that of controls) in 3-week-old superovulated females
• trapped oocytes in luteinizing structures in hormonally stimulated females

embryo
• embryos generated from matings of mutant females and wild-type males become developmentally arrested between the 1-cell and 4-cell stages

cellular
• increased mono-methylated H3K4 in oocytes
• decreased tri-methylated H3K4 in oocytes

homeostasis/metabolism
• increased serum FSH levels at 8 weeks old

endocrine/exocrine glands
• decreased number of primordial follicles at 3 weeks old
• increased number of secondary and preantral follicles at 3 weeks old
• decreased number of primordial follicles and preantral follicles at 8 weeks old
• increased number of atretic follicles at 8 weeks old




Genotype
MGI:5910025
cn2
Allelic
Composition
Bcas2tm1.1Lil/Bcas2tm1.1Lil
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcas2tm1.1Lil mutation (0 available); any Bcas2 mutation (12 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

reproductive system

cellular




Genotype
MGI:5294568
cn3
Allelic
Composition
Tet3tm1.1Gxu/Tet3tm1.2Gxu
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129 * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet3tm1.1Gxu mutation (0 available); any Tet3 mutation (35 available)
Tet3tm1.2Gxu mutation (0 available); any Tet3 mutation (35 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• paternal genome reprogramming is impaired in offspring of mutant females
• paternal genome reprogramming is impaired in offspring of mutant females
• inheriting the mutant allele maternally impairs embryonic survival




Genotype
MGI:5297814
cn4
Allelic
Composition
Foxn1tm1.1Cbln/Foxn1+
Tg(Zp3-cre)3Mrt/?
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Cbln mutation (0 available); any Foxn1 mutation (88 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• normal thymus development and function




Genotype
MGI:3714394
cn5
Allelic
Composition
H19tm6Tilg/H19tm6Tilg
Tg(Zp3-cre)3Mrt/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H19tm6Tilg mutation (0 available); any H19 mutation (11 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• imprinting of Igf2 is not altered




Genotype
MGI:5523431
cn6
Allelic
Composition
Porcntm1.1Jrt/Porcn+
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (17 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• heterozygous females implant normally when the mutant allele ant the cre transgene are from the mother and the reporter is from the father




Genotype
MGI:5523432
cn7
Allelic
Composition
Porcntm1.1Jrt/Y
Tg(CAG-EGFP)D4Nagy/0
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCr * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Porcntm1.1Jrt mutation (1 available); any Porcn mutation (17 available)
Tg(CAG-EGFP)D4Nagy mutation (2 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• hemizygous males fail to gastrulate when mutant and cre are derived from the mother and the reporter is derived from the father




Genotype
MGI:3050792
cn8
Allelic
Composition
Scn8atm1Mm/Scn8atm1Mm
Tg(Zp3-cre)3Mrt/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8atm1Mm mutation (0 available); any Scn8a mutation (68 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• died between 3 and 4 weeks of age

behavior/neurological
• by 14 days of age
• follows development of ataxia




Genotype
MGI:3653735
cn9
Allelic
Composition
Zeb1tm2Yhi/Zeb1tm2Yhi
Zeb2tm1.1Yhi/Zeb2tm1.1Yhi
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)3Mrt mutation (2 available)
Zeb1tm2Yhi mutation (1 available); any Zeb1 mutation (43 available)
Zeb2tm1.1Yhi mutation (1 available); any Zeb2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• embryo turning does not occur
• developmental arrest around E8.5
• defects in neural plate as shown by decreased Sox2 expression
• exhibit a marked thinning of the portion that normally forms the dorsal half of the neural tube
• neural tube fails to close; exhibit a wider opening of the neural tube than single homozygous Zfhx1b mice
• somite cleavage stops at somite 7 while embryo elongation continues
• aberrant positioning of somite cleavage with normal production of presomitic mesoderm
• short somites

nervous system
• defects in neural plate as shown by decreased Sox2 expression
• exhibit a marked thinning of the portion that normally forms the dorsal half of the neural tube
• neural tube fails to close; exhibit a wider opening of the neural tube than single homozygous Zfhx1b mice




Genotype
MGI:3687951
cn10
Allelic
Composition
Tfap2ctm1Will/Tfap2ctm2Will
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2ctm1Will mutation (0 available); any Tfap2c mutation (17 available)
Tfap2ctm2Will mutation (1 available); any Tfap2c mutation (17 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• blastocyts derived from zygotes lacking both maternal and zygotic Tcfap2c contributions make it through preimplantation development




Genotype
MGI:3687952
cn11
Allelic
Composition
Tfap2atm1Hsv/Tfap2atm2Will
Tfap2ctm1Will/Tfap2ctm2Will
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2atm1Hsv mutation (1 available); any Tfap2a mutation (18 available)
Tfap2atm2Will mutation (1 available); any Tfap2a mutation (18 available)
Tfap2ctm1Will mutation (0 available); any Tfap2c mutation (17 available)
Tfap2ctm2Will mutation (1 available); any Tfap2c mutation (17 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• a significant reduction in number of double-null embryos (5.5% vs 25% expected) compared to 3 other possible genotypic combinations results in earlier lethality than loss of either allele alone (~E7.5)

embryo
N
• double-null embryos are found at ~expected frequencies (~25%) at E3.5; embryos are detected in both the morula (~75%) and blastocyst (~25%) stages, indicating that deficiency of both Tcfap2a and Tcfap2c does not affect the zygote prior to E3.5;
• other genotypic combinations are all found at similar frequencies (~25%) at E7.5, indicating that loss of any combination of 3 of 4 wild-type Tcfap2a and Tcfap2c alleles allows embryo survival to ~E7.5




Genotype
MGI:3687953
cn12
Allelic
Composition
Tfap2atm2Will/Tfap2a+
Tfap2ctm1Will/Tfap2ctm2Will
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2atm2Will mutation (1 available); any Tfap2a mutation (18 available)
Tfap2ctm1Will mutation (0 available); any Tfap2c mutation (17 available)
Tfap2ctm2Will mutation (1 available); any Tfap2c mutation (17 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• embryos are smaller than wild-type, with morphology similar to published reports of Tcfap2c-null embryos
• embryos are more disorganized than wild-type, with morphology similar to published report of Tcfap2c-null embryos
• embryos are more disorganized than wild-type, with morphology similar to published report of Tcfap2c-null embryos

growth/size/body
• embryos are smaller than wild-type, with morphology similar to published reports of Tcfap2c-null embryos




Genotype
MGI:5518769
cn13
Allelic
Composition
Mybl2tm1.1Jof/Mybl2+
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybl2tm1.1Jof mutation (0 available); any Mybl2 mutation (123 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 9 of 13 mice have enlarged spleens at 22 months of age

hematopoietic system
• 9 of 13 mice have enlarged spleens at 22 months of age
• 12 of 13 mice at 22 months of age show multiple myeloid disorders
• 46% (6 of 13) of mice develop myelodysplasia (MDS)
• 38% (5 of 13) of mice develop myeloproliferative neoplasms (MPN)
• 7% (1 of 13) of mice develop myeloid leukemia
• transplantation of mutant bone marrow cells into lethally irradiated recipients accelerates development of MDS
• peripheral blood and spleen of mice that develop MDS show an increase in myeloid populations
• 3 of 5 mice that develop MPN, with or without anemia, with or without thrombocytopenia, show an increase in the myeloid population in peripheral blood, bone marrow, and spleen
• signs of anemia and changes in white blood cell counts are detectable between 12 and 18 months of age and exacerbated by 22 months
• mutants that develop MPN show myeloproliferation in the bone marrow with high cellularity and practically no fat cells
• peripheral blood of mice that develop MDS shows dyserythropoiesis that includes anisocytosis and poikilocytosis and the presence of Howell-Jolly bodies
• decrease in red blood cells in mice that develop MDS or MPN
• in mice that develop MDS
• in mice that develop MDS
• in mice that develop MDS
• some mice show thrombocytopenia and others thrombocytosis
• some mice show thrombocytopenia and others thrombocytosis
• decrease in white blood cells in mice that develop MDS
• peripheral blood of mice that develop MDS shows neutropenia
• increase in white blood cells in mice that develop MPN
• the mouse that develops myeloid leukemia shows a dramatic increase in the percentage of granulocytes
• the mouse that develops myeloid leukemia shows a dramatic increase in the percentage of monocytes

immune system
• 9 of 13 mice have enlarged spleens at 22 months of age
• 12 of 13 mice at 22 months of age show multiple myeloid disorders
• 46% (6 of 13) of mice develop myelodysplasia (MDS)
• 38% (5 of 13) of mice develop myeloproliferative neoplasms (MPN)
• 7% (1 of 13) of mice develop myeloid leukemia
• transplantation of mutant bone marrow cells into lethally irradiated recipients accelerates development of MDS
• peripheral blood and spleen of mice that develop MDS show an increase in myeloid populations
• 3 of 5 mice that develop MPN, with or without anemia, with or without thrombocytopenia, show an increase in the myeloid population in peripheral blood, bone marrow, and spleen
• decrease in white blood cells in mice that develop MDS
• peripheral blood of mice that develop MDS shows neutropenia
• increase in white blood cells in mice that develop MPN
• the mouse that develops myeloid leukemia shows a dramatic increase in the percentage of granulocytes
• the mouse that develops myeloid leukemia shows a dramatic increase in the percentage of monocytes

neoplasm
• 7% (1 of 13) of mice develop myeloid leukemia with marked leukocytosis, anemia, and in increase in the number of platelets
• the one mouse that develops a myeloid neoplasm shows the mild increase in platelet number and anemia at 12 to 18 months of age, whereas the massive increase of white blood cells starts after 18 months of age
• the mouse that develops a myeloid neoplasm shows immature myeloid cells in the blood, exhibits white bones, splenomegaly, and disruption of spleen architecture with loss of lymphatic follicles and an increase in the number of megakaryocytes and infiltration of myeloid cells in the liver




Genotype
MGI:3692538
cn14
Allelic
Composition
Mc4rtm1Lowl/Mc4rtm1Lowl
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (37 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice homozygous for reactivated Mc4r in the germline show normal body weights and rescue of the increased snout-anus length observed in Mc4rtm1Lowl homozygotes




Genotype
MGI:3698138
cn15
Allelic
Composition
Rasgrf1tm4.1Pds/Rasgrf1+
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrf1tm4.1Pds mutation (0 available); any Rasgrf1 mutation (41 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• Rasgrf1 expression from paternal allele is silenced in neonatal brain
• DNA from progeny has lost almost all differentially methylated domain (DMD) methylation from the paternal allele
• methylation on floxed allele cannot be maintained upon cre-mediated recombination in zygote




Genotype
MGI:3850044
cn16
Allelic
Composition
Nlrp3tm1Hhf/Nlrp3+
Tg(Zp3-cre)3Mrt/?
Genetic
Background
involves: 129/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3tm1Hhf mutation (1 available); any Nlrp3 mutation (42 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis

growth/size/body
• mutant pups gained weight slowly, and then lost weight before dying

immune system
• white blood cell count is mildly elevated
• pronounced neutrophilia is evident in these mice
• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic

digestive/alimentary system
• substantial necrosis occurs in the gut that is not associated with inflammation

renal/urinary system
• substantial necrosis occurs in the kidney that is not associated with inflammation

hematopoietic system
• thrombocytosis is evident in these mice
• white blood cell count is mildly elevated
• pronounced neutrophilia is evident in these mice

integument
• hair growth does not occur in these mice
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4
• 1-2 day old mice have skin abscesses that develop into erythema and scaly skin by day 4




Genotype
MGI:6452499
cn17
Allelic
Composition
Ndc80tm1Tski/Ndc80tm1Tski
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndc80tm1Tski mutation (0 available); any Ndc80 mutation (28 available)
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• aberrant anaphase I in oocytes results in egg aneuploidies

reproductive system
• oocytes undergo aberrant anaphase I accompanied by degradation of securing, indicating spindle checkpoint defects; aberrant anaphase results in egg aneuploidies
• the microtubule mass undergoes dynamic and aberrant shape changes in oocytes and fails to establish a stable bipolar-shaped spindle during meiosis I, resulting in severe kinetochore-microtubule attachment defects, with some chromosomes falling off the microtubule mass
• although oocytes frequently establish a stable bipolar-shaped spindle in meiosis II, bipolar-shaped spindles exhibit massive chromosome misalignment in metaphase II




Genotype
MGI:5911743
cn18
Allelic
Composition
Ythdf2tm1.1Doca/Ythdf2tm1.1Doca
Tg(Zp3-cre)3Mrt/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)3Mrt mutation (2 available)
Ythdf2tm1.1Doca mutation (0 available); any Ythdf2 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• fertilized zygotes fail to develop beyond the two-cell stage

reproductive system
• despite the presence of corpora lutea, normal induced ovulation and normal fertilization




Genotype
MGI:3835424
tg19
Allelic
Composition
Tg(Zp3-cre)3Mrt/Tg(Zp3-cre)3Mrt
Genetic
Background
FVB/N-Tg(Zp3-cre)3Mrt/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• females are subfertile, producing an average of 3.7 pups per litter




Genotype
MGI:3835441
tg20
Allelic
Composition
Tg(Zp3-cre)3Mrt/0
Genetic
Background
B6.FVB-Tg(Zp3-cre)3Mrt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)3Mrt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• females are subfertile, producing an average of 2.5 pups per litter





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory