reproductive system
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• ovaries from 4-, 6-, and 12-week old females weigh 18-23% less than those of control females
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• oviducts from 4-, 6-, and 12-week old females weigh 18-23% less than those of control females
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• uterI from 4-, 6-, and 12-week old females weigh 18-23% less than in control females
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• litters from homozygous females are have fewer pups compared to those of control females
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behavior/neurological
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• some mutant females display reluctant nursing behavior
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endocrine/exocrine glands
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• thymus in female mice is larger than in control females
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• mammary glands in 4-, 6-, and 12-week old females weigh 18-23% less than in control female littermates
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• by fourth to sixth weeks of age, ductal system has 30-50% less extension with reduced numbers of terminal end buds than in control females
• at maturity (8, 16 and 20 weeks) mammary glands are filled with large bloated ducts terminating with bloated ends; glands have fewer secondary and tertiary ductal branches compared to controls; during pregnancy, retarded ductal branches are partially restored, but mutant mammary glands still have less milk-producing alveoli than control glands
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• ovaries from 4-, 6-, and 12-week old females weigh 18-23% less than those of control females
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• retardation of mammary gland development may affect capacity of females to provide milk for their offspring
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hematopoietic system
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• thymus in female mice is larger than in control females
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immune system
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• thymus in female mice is larger than in control females
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integument
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• mammary glands in 4-, 6-, and 12-week old females weigh 18-23% less than in control female littermates
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• by fourth to sixth weeks of age, ductal system has 30-50% less extension with reduced numbers of terminal end buds than in control females
• at maturity (8, 16 and 20 weeks) mammary glands are filled with large bloated ducts terminating with bloated ends; glands have fewer secondary and tertiary ductal branches compared to controls; during pregnancy, retarded ductal branches are partially restored, but mutant mammary glands still have less milk-producing alveoli than control glands
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• retardation of mammary gland development may affect capacity of females to provide milk for their offspring
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